A unique combination of transcription factors controls differentiation of thyroid cells

Damante, Giuseppe; Tell, Gianluca; Lauro, Roberto Di

doi:10.1016/s0079-6603(00)66033-6

Cited by 183 publications

(151 citation statements)

References 216 publications

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“…TTF-1 is a homeodomain-containing transcription factor that regulates the transcriptional activation of Tg, TPO, and NIS [45] . Tg, the predominant component of colloid in the follicular lumen, is a secretory protein that provides the backbone for circulating thyroid hormones and contains significant amounts of iodine.…”

Section: Discussionmentioning

confidence: 99%

Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

et al. 2014

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Aim: Excess dietary fat intake can induce lipotoxicity in non-adipose tissues. The aim of this study was to observe the effects of dietary high-fat lard intake on thyroid in rats. Methods: Male Sprague-Dawley rats were fed a high-fat lard diet for 24 weeks, and then the rats were fed a normal control diet (acute dietary modification) or the high-fat lard diet for another 6 weeks. The serum lipid profile, total thyroxine (TT4), free thyroxine (FT4) and thyrotropin (TSH) levels were determined at the 12, 18, 24 and 30 weeks. High-frequency ultrasound scanning of the thyroid glands was performed at the 24 or 30 weeks. After the rats were sacrificed, the thyroid glands were collected for histological and immunohistochemical analyses. Results: The high-fat lard diet significantly increased triglyceride levels in both the serum and thyroid, and decreased serum TT4 and FT4 levels in parallel with elevated serum TSH levels. Ultrasonic imaging revealed enlarged thyroid glands with lowered echotexture and relatively heterogeneous features in the high-fat lard fed rats. The thyroid glands from the high-fat lard fed rats exhibited enlarged follicle cavities and flattened follicular epithelial cells under light microscopy, and dilated endoplasmic reticulum cisternae, twisted nuclei, fewer microvilli and secretory vesicles under transmission electron microscopy. Furthermore, the thyroid glands from the highfat lard fed rats showed markedly low levels of thyroid hormone synthesis-related proteins TTF-1 and NIS. Acute dietary modification by withdrawal of the high-fat lard diet for 6 weeks failed to ameliorate the high-fat lard diet-induced thyroid changes. Conclusion: Dietary high-fat lard intake induces significant thyroid dysfunction and abnormal morphology in rats, which can not be corrected by short-term dietary modification.

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Section: Discussionmentioning

confidence: 99%

Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

et al. 2014

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“…Three thyroidspecific transcription factors, thyroid transcription factor (TTF)-1, TTF-2, and Pax-8, are responsible for thyroid-specific gene expression (5). TTF-1 is a homeoprotein whose expression is restricted to thyroid, lung, and the developing brain (6).…”

Section: Furthermore Chromatin Immunoprecipitation Experiments In Frmentioning

confidence: 99%

Transcriptional Repressor DREAM Interacts with Thyroid Transcription Factor-1 and Regulates Thyroglobulin Gene Expression

Rivas

Mellström

Naranjo

et al. 2004

Journal of Biological Chemistry

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Tissue-specific gene expression depends on the interaction between tissue-specific and general transcription factors. DREAM is a Ca 2؉ -dependent transcriptional repressor widely expressed in the brain where it participates in nociception through its control of prodynorphin gene expression. In the periphery, DREAM is highly expressed in the thyroid gland, the immune system, and the reproductive organs. Here, we show that DREAM interacts with thyroid-specific transcription factor TTF-1 and regulates the expression of the thyroglobulin (Tg) gene. The mechanism also involves binding of DREAM to the thyroglobulin promoter and blockage of TTF-1-mediated transactivation. The TSH/cAMP pathway and Ca 2؉ signaling regulate DREAM-mediated transcriptional repression of the thyroglobulin gene. Furthermore, chromatin immunoprecipitation experiments in FRTL-5 cells confirmed that Tg is a bona fide target gene for DREAM transrepression in thyroid follicular cells.

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“…A homeodomain transcription factor, T/ebp (also called Ttf1, Titf1, or Nkx2.1) (Guazzi et al, 1990;Mizuno et al, 1991), is one of the transcription factors essential for regulating the expression of genes involved in thyroid hormone synthesis as well as thyroid organogenesis (Kimura et al, 1996;De Felice et al, 1998;Mansouri et al, 1998;Damante et al, 2001;Di Lauro and De Felice, 2001;De Felice and Di Lauro, 2004). Mice carrying a null mutation for T/ebp gene die at birth due to profoundly hypoplastic lungs, a defective hypothalamus, and absence of the thyroid and pituitary glands (Kimura et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid

Kusakabe

Hoshi

Kimura

2005

Developmental Dynamics

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A unique combination of transcription factors controls differentiation of thyroid cells

Cited by 183 publications

References 216 publications

Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

Transcriptional Repressor DREAM Interacts with Thyroid Transcription Factor-1 and Regulates Thyroglobulin Gene Expression

Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid

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