Transcriptional Repressor DREAM Interacts with Thyroid Transcription Factor-1 and Regulates Thyroglobulin Gene Expression

Rivas, Marcos; Mellström, Britt; Naranjo, José R.; Santisteban, Pilar

doi:10.1074/jbc.m403526200

Cited by 71 publications

(88 citation statements)

References 49 publications

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“…Dyrk1a is a multifaceted kinase involved in growth control (FernandezMartinez et al, 2015) and is a central player in the Hippo pathway regulating organ size (Dick and Mymryk, 2011). In this process, Dyrk1a interacts with Dream (Kcnip3), a transcriptional repressor that is also known to suppress thyroid function by downregulating thyroid-specific gene expression (Rivas et al, 2004;D'Andrea et al, 2005). This suggests a putative role for Dream in thyroid developmental growth and differentiation that warrants further investigation.…”

Section: The Proliferation Of Thyroid Progenitors and Follicular Precmentioning

confidence: 99%

Development of the thyroid gland

2017

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Thyroid hormones are crucial for organismal development and homeostasis. In humans, untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism, which comprises irreversible brain dysfunction and dwarfism. Elucidating how the thyroid gland -the only source of thyroid hormones in the bodydevelops is thus key for understanding and treating thyroid dysgenesis, and for generating thyroid cells in vitro that might be used for cell-based therapies. Here, we review the principal mechanisms involved in thyroid organogenesis and functional differentiation, highlighting how the thyroid forerunner evolved from the endostyle in protochordates to the endocrine gland found in vertebrates. New findings on the specification and fate decisions of thyroid progenitors, and the morphogenesis of precursor cells into hormone-producing follicular units, are also discussed.

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Section: The Proliferation Of Thyroid Progenitors and Follicular Precmentioning

confidence: 99%

Development of the thyroid gland

2017

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“…The mechanism by which DREAM transactivates the GFAP promoter in response to calcium is likely to involve changes in protein conformation (Carrió n et al, 1999;Osawa et al, 2001Osawa et al, , 2005 that could be stabilized by interactions with other proteins bound in close proximity (Rivas et al, 2004;Gomez-Villafuertes et al, 2005;Scsucova et al, 2005). Of note, the transcription factor nuclear factor-I is important for GFAP expression and occupies a site in the GFAP promoter located adjacent to DRE2 (Cebolla and Vallejo, 2006).…”

Section: Dream As a Transcriptional Transactivator Of The Gfap Genementioning

confidence: 99%

DREAM Mediates cAMP-Dependent, Ca2+-Induced Stimulation of GFAP Gene Expression and Regulates Cortical Astrogliogenesis

Cebolla¹,

Fernández-Pérez²,

Perea³

et al. 2008

Journal of Neuroscience

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In the developing mouse brain, once the generation of neurons is mostly completed during the prenatal period, precisely coordinated signals act on competent neural precursors to direct their differentiation into astrocytes, which occurs mostly after birth. Among these signals, those provided by neurotrophic cytokines and bone morphogenetic proteins appear to have a key role in triggering the neurogenic to gliogenic switch and in regulating astrocyte numbers. In addition, we have reported previously that the neurotrophic peptide pituitary adenylate cyclase-activating polypeptide (

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“…Recent studies revealed that in addition to direct binding to DNA through downstream regulatory elements (DRE), DREAM can also interact and modulate the action of transcriptional factors through protein-protein interaction (Ledo et al, 2002;Rivas et al, 2004;Zaidi et al, 2006). In the NSE region of the GnRH promoter, there are no sequences that offer a high degree of homology to consensus DRE sequence.…”

Section: Emsa Analysis Of Dream Binding To the Oct1bs-a Sitementioning

confidence: 99%

Calcium influx and DREAM protein are required for GnRH gene expression pulse activity

Leclerc

Boockfor

2007

Molecular and Cellular Endocrinology

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Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events. To determine whether calcium or DREAM may play a role in linking these processes, we used an L-type Ca 2+ -blocker (nimodipine) and found that not only GnRH gene expression (GnRH-GE) pulse activity was abolished but also that binding of proteins to OCT1BS-a (essential site for GnRH-GE pulses) was reduced. We further found that only EF-hand forms of DREAM were expressed in GT1-7 and that DREAM was part of the complex binding to OCT1BS-a. Finally, microinjection of DREAM antibody into cells abolished GnRH-GE pulses demonstrating its importance in pulsatility. These results reveal that calcium and DREAM may bridge cytoplasmic and nuclear events enabling temporal coordination of intermittent activity. Expression of DREAM in various cell types coupled with the universal role of calcium raise the possibility that these factors may play similar role in other secretory cells.

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Transcriptional Repressor DREAM Interacts with Thyroid Transcription Factor-1 and Regulates Thyroglobulin Gene Expression

Cited by 71 publications

References 49 publications

Development of the thyroid gland

Development of the thyroid gland

DREAM Mediates cAMP-Dependent, Ca2+-Induced Stimulation of GFAP Gene Expression and Regulates Cortical Astrogliogenesis

Calcium influx and DREAM protein are required for GnRH gene expression pulse activity

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