A Unique CD27<sup>-</sup>IgD<sup>-</sup> B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity

Tan, Nadia Suray; Mukherjee, Manali; Lim, Sheau Yng; Rouers, Angéline; Hwang, You Yi; Thiam, Chung Hwee; Tan, W.S. Daniel; Liao, Wupeng; Wong, Winnie; Liew, Mei Fong; Nair, Parameswaran; Larbi, Anis; Wang, De Yun; Fink, Katja; Angeli, Véronique; Lim, Hui Fang

doi:10.1165/rcmb.2022-0137le

Cited by 2 publications

(1 citation statement)

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“…This is reinforced by the correlation between autoimmune responses, B cell counts, and activated eosinophils in the airways of patients with SA. 7 12 35 Polyclonal IgE against EPx and ECP has been reported to be higher patients with SA than in healthy controls. 12 In addition, patients with OCS-dependent SA have been reported to have elevated levels of EPx-specific IgG autoantibody and ANA in their sputa.…”

Section: Autoimmune Mechanism Possible Biomarkers and Noble Treatment...mentioning

confidence: 99%

Immune Cell-Mediated Autoimmune Responses in Severe Asthma

Cao,

Quoc,

Jang

et al. 2024

Yonsei Med J

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Severe asthma (SA) has heterogeneous inflammatory phenotypes characterized by persistent airway inflammation (eosinophilic and/or neutrophilic inflammation) and remodeling. Various immune cells (eosinophils, neutrophils, and macrophages) become more activated and release inflammatory mediators and extracellular traps, damaging the protective barrier of airway epithelial cells and further activating other immune and structural cells. These cells play a role in autoimmune responses in asthmatic airways, where the adaptive immune system generates autoantibodies, inducing immunoglobulin G-dependent airway inflammation. Recent studies have suggested that adult asthmatics had high titers of autoantibodies associated with asthma severity, although pathogenic factors or diagnostic criteria are not well-defined. This challenge is further compounded by asthmatics with the autoimmune responses showing therapy insensitivity or failure to current pharmacological and biological treatment. This review updates emerging mechanisms of autoimmune responses in asthmatic airways and provides insights into their roles, proposing potential biomarkers and therapeutic targets for SA.

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