A unique case of distant skin metastasis from chondroid chordoma

Riesco-Martinez, M.C.; Parrilla-Rubio, Lucía; Enguita-Valls, Ana Belén; Delgado-Márquez, Ana María; Ruste, Sherry A.; López-Martín, Jose-A.

doi:10.1016/j.jdcr.2015.11.014

Cited by 6 publications

(6 citation statements)

References 17 publications

(15 reference statements)

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“…Skin involvement in chordoma usually occurs as a result of direct spread of the primary tumor, termed chordoma cutis 7 . Distant skin metastasis of chordoma, especially in isolation, is exceptionally rare, with only about 20 cases previously reported 5–21 . Such cases tend to occur late in the disease course, as was the case in our patients, who presented with distant skin metastasis 9 and 6 years, respectively, following the initial diagnosis.…”

Section: Discussionmentioning

confidence: 49%

“…The metastases in both of our patients exhibited the typical findings of conventional chordoma, with a lobular proliferation of epithelioid cells with occasional physaliphorous cells in a myxoid stroma. Although both of our patients had lesions confined to the dermis, epidermal involvement and ulceration has also been described 17 . In addition, fine needle aspiration diagnosis of metastatic chordoma has been reported, indicating that this is an alternative diagnostic approach 23…”

Section: Discussionmentioning

confidence: 51%

“…7 Distant skin metastasis of chordoma, especially in isolation, is exceptionally rare, with only about 20 cases previously reported. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Such cases tend to occur late in the disease course, as was the case in our patients, who presented with distant skin metastasis 9 and 6 years, respectively, following the initial diagnosis. Previously reported primary tumor sites for chordoma metastasizing to skin include the sacrum, cervical spine, and skull base.…”

Section: Discussionmentioning

confidence: 82%

“…Although both of our patients had lesions confined to the dermis, epidermal involvement and ulceration has also been described. 17 In addition, fine needle aspiration diagnosis of metastatic chordoma has been reported, indicating that this is an alternative diagnostic approach. 23 On immunohistochemical investigation, the metastases in both of our patients exhibited brachyury positivity, leading to the correct F I G U R E 2 Hepatic and cutaneous metastasis from Case 2.…”

Section: Discussionmentioning

confidence: 99%

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Chordoma metastatic to skin: A report of two cases and a brief review of the literature

et al. 2022

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Chordomas are rare, locally aggressive tumors of notochordal origin usually arising in the spine or base of the skull. Skin involvement is rare and typically occurs via direct extension of the primary tumor to the skin. Although there are increasing reports of the skin being involved as a distant metastatic site in patients with chordoma, this remains an exceedingly rare occurrence. We present two cases of patients diagnosed with metastasis of chordoma to the skin that represented distant metastasis. In the first case, a patient with a primary thoracic/lumbar chordoma presented with isolated metastasis to the skin of the left lower jaw 9 years after initial diagnosis of the chordoma. To our knowledge, this is the first reported case of a chordoma of this site to develop distant skin metastasis. In the second case, a patient with a primary sacral chordoma presented with metastasis to the skin of the right side of his chin 6 years after initial diagnosis of the chordoma, following previous metastatic spread to the liver and lung. Finally, we briefly review the literature on chordoma metastasis to the skin and highlight salient features to raise awareness of this uncommon occurrence.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Chordoma metastatic to skin: A report of two cases and a brief review of the literature

et al. 2022

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“…They are slow-growing tumors with a tendency to recur, presenting an aggressive clinical course frequently associated with metastasis 1, 2. Skin and subcutaneous tissue involvement is unusual but may eventually occur as a result of local infiltration and/or metastasis 3, 4…”

Section: Introductionmentioning

confidence: 99%