Metastatic chordoma

Conde, Maria Florencia Suárez; Vallone, María Gabriela; González, Virginia; Vigovich, Félix; Casas, José Guadalupe; Cermignan, Luciano; Bas, Carlos; Larralde, Margarita

doi:10.1016/j.jdcr.2019.07.029

Cited by 3 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other possibilities that should also be considered in the differential diagnosis include metastases to the skin from chondrosarcoma and chordoma. [7][8][9][10] These tumors usually occur in adults with an established history of a bone tumor; the histopathologic features will usually be similar to that of the primary tumor. Our patient did not have a history of bone tumor, and cytokeratin stain was negative.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Other tumors containing cartilaginous matrix in the skin include chondroid syringoma and metastases from chordoma or chondrosarcoma of bones. [4][5][6][7][8][9][10] Tumors of the skin composed of a population of cells that resemble immature cartilage have, to the best of our knowledge, not yet been described. We report a case of a skin tumor in a 68-yearold woman that was characterized by a well-circumscribed proliferation of what appeared to represent immature cartilage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immature Chondroid Choristoma: Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Benign Skin Tumor

Suster

Ronen

Mackinnon

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

An unusual benign skin tumor is reported occurring in a 68-year-old woman with no significant medical history. The lesion presented as a small skin nodule in the neck. Histologic examination showed a well-circumscribed superficial dermal nodule composed of a solid proliferation of large, round cells with abundant eosinophilic cytoplasm and small centrally placed nuclei displaying a vaguely chondroid appearance. Immunohistochemical studies showed strong positivity of the tumor cells for S100 protein and vimentin and negative staining for SOX10, melanoma cocktail, HMB45, Melan-A, cytokeratin AE1/AE3, inhibin, desmin, smooth muscle actin, CD68, CD164, and neuron specific enolase. Next-generation sequencing using a panel of 50 actionable genes commonly encountered in human neoplasia did not reveal the presence of any mutations. Owing to the remarkable similarity of the lesion to immature cartilage, we consider this to be a benign tumor, most likely resulting from an embryologic defect. We propose the term immature chondroid choristoma to designate this lesion.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immature Chondroid Choristoma: Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Benign Skin Tumor

Suster

Ronen

Mackinnon

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…In patients younger than 20, they are usually skull-based chordomas [ 3 ]. They tend to metastasize to the lung, liver, and bone [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

A rare posterior mediastinal mass: chordoma

Willatt,

Wollheim,

Ehrsam

et al. 2024

Journal of Surgical Case Reports

View full text Add to dashboard Cite

A 72-year-old female presented with 2 years of pro-gradient pain in the upper thoracic spine radiating to the left arm and leg. MRI revealed a 2.7 × 2.0 × 12 cm paravertebral mass at T2/T3, extending into the foraminal and epidural nerves with extensive dural sac contact in the left hemithorax. The removed tumour was surprisingly soft for a schwannoma or chordoma. However, after the surgery, histopathology revealed the presence of brachyury protein (T-box transcription factor T), which is characteristic of a chordoma. While chordomas are extremely rare, it is important that they are kept in mind for the differential diagnosis of a posterior mediastinal mass. Successful treatment can only be achieved through a complete en bloc resection. This can often be complex due to their location along the spine. This case report aims to highlight the features and treatment of this rare disease.

show abstract

“…Macroscopically, a multilobulated tumor with translucent, gelatinous appearance and occasional telangiectasia is found 4 ; therefore, dermoscopic examination may be useful 5 . The histopathologic features of the primary tumor and metastases are similar 6 .…”

Section: Discussionmentioning

confidence: 99%

A rare case of chordoma cutis

Jung,

Ko,

Seo

et al. 2023

J Cutan Pathol

View full text Add to dashboard Cite

Chordoma is a rare locally aggressive bone malignancy that originates from the notochord. It typically involves the sacrococcygeal area, spheno‐occipital region of the skull, and spine. Cutaneous involvement of chordoma, termed as chordoma cutis, is uncommon and usually occurs via direct invasion or local recurrence. Distant metastasis to the skin is very rare. We report a case of chordoma cutis on the scalp, which lacked characteristic physaliferous cells but tested positive for brachyury, thus supporting the diagnosis of chordoma cutis. The patient, who presented with a solitary translucent nodule on the scalp, was previously diagnosed with chordoma on the vertebral column and skull 8 months prior. Microscopic examination showed a cord‐like arrangement of plasmacytoid cells within a myxoid stroma. Physaliferous cells were not observed, and cytokeratin AE1/AE3 staining was negative; however, brachyury and epithelial membrane antigen staining was positive, leading to the diagnosis of chordoma cutis. Therefore, clinicians must include chordoma cutis in the differential diagnosis of translucent nodular lesions on the skin of patients formerly diagnosed with chordoma.

show abstract

Metastatic chordoma

Cited by 3 publications

References 9 publications

Immature Chondroid Choristoma: Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Benign Skin Tumor

Immature Chondroid Choristoma: Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Benign Skin Tumor

A rare posterior mediastinal mass: chordoma

A rare case of chordoma cutis

Contact Info

Product

Resources

About