A “turn-off” fluorescent biosensor for the detection of mercury (II) based on graphite carbon nitride

Li, Jingshuai; Wang, Huan; Guo, Zhaoheng; Wang, Yaoguang; Ma, Hongmin; Ren, Xiang; Du, Bin; Wei, Qin

doi:10.1016/j.talanta.2016.09.066

Cited by 64 publications

(27 citation statements)

References 36 publications

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“…Another interesting study on a “turn-off” fluorescence biosensor based on graphitic carbon nitride (g-C 3 N 4 ) was reported for the detection of Hg 2+ [ 38 ]. In comparison, this biosensor system was fabricated by the functionalization of graphitic carbon nitride (g-C 3 N 4 ) with single-stranded DNA (ssDNA) aptamer.…”

Section: Multifunctional Applications Of Graphitic Carbon Nitride mentioning

confidence: 99%

“…The sensor was reported to have good selectivity with a detection limit of 0.17 nM. The g-C 3 N 4 -based fluorescence sensor was said to be a promising tool for the detection of metal ions in real samples [ 38 ]. Moreover, an ion-imprinted polymer, in conjunction with graphitic carbon nitride (g-C 3 N 4 ) was used to develop a highly sensitive and selective electrochemical sensor to detect Hg 2+ [ 39 ].…”

Section: Multifunctional Applications Of Graphitic Carbon Nitride mentioning

confidence: 99%

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Graphitic Carbon Nitride: A Highly Electroactive Nanomaterial for Environmental and Clinical Sensing

Idris

Oseghe

Msagati

et al. 2020

Sensors

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Graphitic carbon nitride (g-C3N4) is a two-dimensional conjugated polymer that has attracted the interest of researchers and industrial communities owing to its outstanding analytical merits such as low-cost synthesis, high stability, unique electronic properties, catalytic ability, high quantum yield, nontoxicity, metal-free, low bandgap energy, and electron-rich properties. Notably, graphitic carbon nitride (g-C3N4) is the most stable allotrope of carbon nitrides. It has been explored in various analytical fields due to its excellent biocompatibility properties, including ease of surface functionalization and hydrogen-bonding. Graphitic carbon nitride (g-C3N4) acts as a nanomediator and serves as an immobilization layer to detect various biomolecules. Numerous reports have been presented in the literature on applying graphitic carbon nitride (g-C3N4) for the construction of electrochemical sensors and biosensors. Different electrochemical techniques such as cyclic voltammetry, electrochemiluminescence, electrochemical impedance spectroscopy, square wave anodic stripping voltammetry, and amperometry techniques have been extensively used for the detection of biologic molecules and heavy metals, with high sensitivity and good selectivity. For this reason, the leading drive of this review is to stress the importance of employing graphitic carbon nitride (g-C3N4) for the fabrication of electrochemical sensors and biosensors.

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Section: Multifunctional Applications Of Graphitic Carbon Nitride mentioning

confidence: 99%

Section: Multifunctional Applications Of Graphitic Carbon Nitride mentioning

confidence: 99%

Graphitic Carbon Nitride: A Highly Electroactive Nanomaterial for Environmental and Clinical Sensing

Idris

Oseghe

Msagati

et al. 2020

Sensors

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“…[90] Copyright 2018, Wiley-VCH Verlag GmbH & Co. KgaA; (f) Reproduced with permission. [91] Copyright 2016, Elsevier B.V.; (g) Reproduced with permission. [89] Copyright 2018, Taylor & Francis; (h) Reproduced with permission.…”

Section: Fluorescence-based G-c 3 N 4 Ion Sensormentioning

confidence: 99%

Host–Guest Recognition on 2D Graphitic Carbon Nitride for Nanosensing

Wang

Zhang

et al. 2019

Adv Materials Inter

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In recent years, graphitic carbon nitride (g-C 3 N 4) has attracted much attention due to its unique properties and excellent performance in the field of sensors, which has inspired the authors to compile this review. Although there are many reviews on the synthesis and applications of g-C 3 N 4 materials, a targeted, systematic, comprehensive summary of applications in sensors and the sensing mechanisms of g-C 3 N 4-based nanomaterials have not been published. In this review, the preparation methods and synthetic conditions for preparing g-C 3 N 4 with different morphologies, such as conventional bulk g-C 3 N 4 , g-C 3 N 4 nanosheets, and g-C 3 N 4 quantum dots, are introduced in detail. By reviewing recent advances in g-C 3 N 4-based nanomaterials in ion sensors, biosensors, gas sensors and humidity sensors, this study provides more comprehensive and in-depth information for the further design of g-C 3 N 4based sensors with enhanced performance. A brief outlook of g-C 3 N 4-based sensors is presented as the conclusion of this review.

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“…Even though DNA-templated QDs were reported for different applications [25,26], to our knowledge no work has been reported for analyte sensing using aptamer-templated QDs. Fluorescence quenching-based sensing has been recently reported for the sensing of Hg 2+ , but the method has its own disadvantage that in real samples, quenching may happen due to various factors other than the presence of analyte [22,27]. Hence, "Turn-On" fluorescent sensors are better than fluorescence quenching-based sensors.…”

Section: Introductionmentioning

confidence: 99%

Handheld, low-cost electronic device for rapid, real-time fluorescence-based detection of Hg2+, using aptamer-templated ZnO quantum dots

Daniel

Kumar

Sivasakthi

et al. 2019

Sensors and Actuators B: Chemical

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Mercury is one of the most acute toxic heavy metals at trace levels and its detection at parts per billion (ppb) scale in a low-cost, simple way remains challenging. Here, we report a novel "Turn-On" fluorescence sensor based on aptamer-templated ZnO quantum dots (QDs), which was further developed into an electronic detection device and utilized for the rapid detection of mercury ions (Hg 2+). Binding of Hg 2+ with the aptamer leads to the formation of a duplex, T-Hg 2+-T, and this acts as a template for the formation of ZnO QDs. With an increase in the concentration of Hg 2+ , we observed an increase in duplex formation, leading to enhancement in the fluorescence. The limit of detection of the device is 0.1 ppb (0.5 nM), and experimental analysis has a linear range of detection between 0.1 and 10,000 ppb. Electron microscopy studies ascertained the crystalline nature of the aptamer-templated ZnO QDs in the presence of Hg 2+. Finally, the sensing was implemented as a simple working electronic detection device prototype. A photodiode coupled with an LED source was connected to an Arduino Nanoboard for the development of the device. To the best of our knowledge, this is the first study to report an enhancement in the fluorescence of the aptamer-templated ZnO QDs with an increase in the concentration of Hg 2+. Moreover, this is the first report of an analyte addition during the synthesis of QDs, leading to fluorescence-based sensing of the added analyte. Thus, a novel fluorescence sensor based on aptamer-templated ZnO QDs has been demonstrated with high sensitivity and selectivity, resulting in a simple electronic detection device.

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A “turn-off” fluorescent biosensor for the detection of mercury (II) based on graphite carbon nitride

Cited by 64 publications

References 36 publications

Graphitic Carbon Nitride: A Highly Electroactive Nanomaterial for Environmental and Clinical Sensing

Graphitic Carbon Nitride: A Highly Electroactive Nanomaterial for Environmental and Clinical Sensing

Host–Guest Recognition on 2D Graphitic Carbon Nitride for Nanosensing

Handheld, low-cost electronic device for rapid, real-time fluorescence-based detection of Hg2+, using aptamer-templated ZnO quantum dots

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