2012
DOI: 10.1159/000342000
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A Trade-Off between Feedback-Based Learning and Episodic Memory for Feedback Events: Evidence from Parkinson’s Disease

Abstract: Parkinson’s disease (PD) is characterized by a loss of dopaminergic projections to the striatum, leading to both motor and cognitive impairments. The cognitive impairments are relatively selective and include deficits in incremental learning from trial-by-trial feedback, while other forms of learning, such as hippocampal-dependent episodic memory, remain intact. Interestingly, it has been suggested that the striatum and the hippocampus compete during learning, leading to the intriguing prediction that the stri… Show more

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Cited by 40 publications
(61 citation statements)
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“…Two age-matched controls were excluded because of low MMSE scores, leaving 18 control participants in the analyses. PD ON were tested within 3 hr of their last medication dose; PD OFF were withdrawn overnight from their medications and tested at least 14 hr after their last medication dose, following prior studies (Foerde, Braun, & Shohamy, 2013;Shohamy, Myers, Geghman, Sage, & Gluck, 2006;Frank, Seeberger, & O'Reilly, 2004;Cools, Barker, Sahakian, & Robbins, 2001). As is common clinical practice, most patients were being treated with a combination of L-dopa and dopamine agonists.…”
Section: Methods Participantsmentioning
confidence: 99%
“…Two age-matched controls were excluded because of low MMSE scores, leaving 18 control participants in the analyses. PD ON were tested within 3 hr of their last medication dose; PD OFF were withdrawn overnight from their medications and tested at least 14 hr after their last medication dose, following prior studies (Foerde, Braun, & Shohamy, 2013;Shohamy, Myers, Geghman, Sage, & Gluck, 2006;Frank, Seeberger, & O'Reilly, 2004;Cools, Barker, Sahakian, & Robbins, 2001). As is common clinical practice, most patients were being treated with a combination of L-dopa and dopamine agonists.…”
Section: Methods Participantsmentioning
confidence: 99%
“…We compared patients with MTL damage to 15 patients (five females) with Parkinson's disease. Patients with a diagnosis of idiopathic Parkinson's disease were recruited through the Columbia University Medical Center Department of Neurology with the assistance of a neurologist (Dr. Lucien Cote) and through the online database Fox Trial Finder (data from six of these participants were reported previously by Foerde and Shohamy, 2011; a separate element of data from 14 of these participants was reported by Foerde et al, 2013). Only patients in mild or moderate disease stages (Hoehn and Yahr stage 1-3) were recruited.…”
Section: Participantsmentioning
confidence: 99%
“…All participants completed a probabilistic learning task adapted from prior studies (Knowlton et al, 1996;Poldrack et al, 2001;Foerde et al, 2006;Foerde and Shohamy, 2011). In this task, participants learn to associate cues with outcomes through trial and error.…”
Section: Taskmentioning
confidence: 99%
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