379 drug-induced EBA is extremely rare, it cannot be fully excluded. Additionally, the blistering eruption of our patient initially developed after cefoperazone. Third-generation cephalosporins comprising a similar backbone structure with cefoperazone, such as ceftazidine, have been speculated to have cross-allergenicity and an additive effect with vancomycin [6]. This speculation is strengthened by the current report, although the underlying mechanism remains to be elucidated. In conclusion, this unique case highlights the pleomorphic nature of vancomycin-induced skin reactions.