Non-melanoma skin cancer comprises the two most common forms of malignant neoplasms found in humans, namely, basal cell carcinoma and squamous cell carcinoma. Seborrheic keratosis is one of the commonest benign epidermal skin lesions that appear in middle-aged or elderly people. Other common epidermal tumors in this chapter include melanoacanthoma, skin tags, dermatosis papulosa nigra, stucco keratosis, and cutaneous horn. Different types of keratoses will be reviewed such as actinic,