Tumors of the epidermis

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00032-2

Cited by 65 publications

(97 citation statements)

References 1,958 publications

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“…Because subcutaneous fat exists in a substantial amount and has large Raman scattering cross section [41] we believe (1) is the major reason. The thickening of epidermis originates from the progression of malignancy [42].…”

Section: Discussionmentioning

confidence: 99%

Raman active components of skin cancer

Feng¹,

Moy²,

Nguyen³

et al. 2017

Biomed. Opt. Express

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Raman spectroscopy (RS) has shown great potential in noninvasive cancer screening. Statistically based algorithms, such as principal component analysis, are commonly employed to provide tissue classification; however, they are difficult to relate to the chemical and morphological basis of the spectroscopic features and underlying disease. As a result, we propose the first Raman biophysical model applied to in vivo skin cancer screening data. We expand upon previous models by utilizing in situ skin constituents as the building blocks, and validate the model using previous clinical screening data collected from a Raman optical fiber probe. We built an 830nm confocal Raman microscope integrated with a confocal laser-scanning microscope. Raman imaging was performed on skin sections spanning various disease states, and multivariate curve resolution (MCR) analysis was used to resolve the Raman spectra of individual in situ skin constituents. The basis spectra of the most relevant skin constituents were combined linearly to fit in vivo human skin spectra. Our results suggest collagen, elastin, keratin, cell nucleus, triolein, ceramide, melanin and water are the most important model components. We make available for download (see supplemental information) a database of Raman spectra for these eight components for others to use as a reference. Our model reveals the biochemical and structural makeup of normal, nonmelanoma and melanoma skin cancers, and precancers and paves the way for future development of this approach to noninvasive skin cancer diagnosis.

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Section: Discussionmentioning

confidence: 99%

Raman active components of skin cancer

Feng¹,

Moy²,

Nguyen³

et al. 2017

Biomed. Opt. Express

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“…Estos tumores pueden aparecer en cualquier parte del cuerpo, pero con mayor frecuencia se desarrollan en áreas expuestas al sol. Carcinógenos químicos y el virus del papiloma humano se han asociado con su etiología pero la exposición excesiva a luz solar se ha sugerido como el principal agente en la mayoría de los casos (1). El pico de incidencia es entre 50 y 69 años de edad y hay una preponderancia masculina (2).…”

Section: Introductionunclassified

Queratoacantoma de vulva: presentación de un caso

et al. 2015

Rev. chil. obstet. ginecol.

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RESUMENEl queratoacantoma de vulva es una entidad rara que podría presentar confusión en su diagnóstico con el carcinoma bien diferenciado de células escamosas. Presentamos un caso de una paciente con diagnóstico de queratoacantoma de vulva tratada con resección quirúrgica de la lesión y su seguimiento posterior. PALABRES CLAVE: Queratoacantoma vulvar, carcinoma vulvar, células escamosas, vulva SUMMARYVulvar keratoacanthoma is a rare disease that may present confusion in diagnosis with well differentiated squamous cell carcinoma. We report one patient with vulvar keratoacanthoma, treated by resection surgery of the lesion and her outcome. KEY WORDS: Vulvar keratoacanthoma, vulvar carcinoma, squamous cell, vulva INTRODUCCIÓNEl queratoacantoma es un tumor de la piel, generalmente solitario, de color rosa o carne, con queratina central en forma de cúpula. Estos tumores pueden aparecer en cualquier parte del cuerpo, pero con mayor frecuencia se desarrollan en áreas expuestas al sol. Carcinógenos químicos y el virus del papiloma humano se han asociado con su etiología pero la exposición excesiva a luz solar se ha sugerido como el principal agente en la mayoría de los casos (1). El pico de incidencia es entre 50 y 69 años de edad y hay una preponderancia masculina (2). Es una neoplasia cutánea común con distintivas características clínicas e histopatológicas similares al carcinoma de células escamosas. Su curso clínico se caracteriza por una fase de rápido crecimiento, seguido por la involución espontánea. Las propiedades invasivas del epitelio escamoso pueden estar presentes en el queratoacantoma, su distinción con el carcinoma de células escamosas bien diferenciado es un diagnóstico difícil que requiere una cuidadosa evaluación (3,4).El queratoacantoma es más común en áreas con exposición al sol, y su presentación en la vulva es rara. Hasta ahora, seis casos de queratoacantoma vulvar se han reportado en la literatura (Tabla I) (5-9).Se presenta el reporte de un caso atendido en nuestra institución luego de ser aceptado por el comité de ética médica. Caso clínicoMujer de 90 años de edad quien consulta por cuadro clínico de un mes de evolución de aparición de lesión en la vulva, dolorosa, de rápido crecimiento, manejada con agentes tópicos sin mejoría. Antecedente de osteoporosis en tratamiento con bifosfonato y sin otro tipo de antecedente importante.Al examen físico se observa lesión nodular, hipopigmentada de 2 cm de diámetro localizada en REV CHIL OBSTET GINECOL 2015; 80(5): 401 -404

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“…9,10,11 Alcohol consumption has been reported to increase the risk of basal cell carcinoma 12 . Also, renal transplant patients are at an increased risk of developing this tumor.…”

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confidence: 99%

“…15 Microscopically, it is characterized by proliferation of fibrocollagenous tissue in whirling 5 pattern, containing scattered macrophages, and occupying the upper, mid and lower dermis; separated from the epidermis by a Grenz zone, poorly demarcated laterally, and rarely extending into the upper subcutis as thin septae or as a welldemarcated bulge. 9,10,11 The dark hue imparted to the skin overlying the dermatofibroma is due to the increase in number of melanin-producing melanocytes in the epidermis. 16 Post-inflammatory pigmentation (3%) or acquired melanosis was commonly found in females (n=2) with male-to-female ratio of 1:2 ( Table-I Table-II), the affected sites being the face, back, and upper limbs (each, n=1) ( Table-III).…”

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confidence: 99%

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Common Pigmented Skin Lesions

Khan¹,

Asghar²,

Akhund³

et al. 2018

TPMJ

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ABSTRACT… Objectives: The purpose of this study is; firstly, to study the histopathological spectrum of the pigmented skin lesions in the community, to signify that not all pigmented skin lesions are malignant melanomas; secondly, to assess the age-wise distribution of the common pigmented skin lesions; and thirdly, to determine the commonly affected body sites by these pigmented skin lesions. Study Design: Retrospective/Observational study. Setting: Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. Period: 100 consecutive cases with clinical diagnosis of pigmented skin lesion, starting in the year 2013. Methods: In this study, 100 consecutive surgical pathology cases with clinical diagnosis of pigmented skin lesion were retrieved from the archives of Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. All the specimens were incisional biopsies of skin, fixed in 10% formalin, embedded in paraffin, and stained with Hematoxylin and Eosin stains. Results: On analyzing 100 consecutive pigmented skin lesions (n=100) starting from the year 2013, it was found thatthe large majority of these lesions were benign. The most common pigmented skin lesion was melanocytic nevus. Moreover, majority of pigmented skin lesions were seen in females. Seborrheic keratosis and malignant tumors, like basal cell carcinoma and squamous cell carcinomas, were more commonly seen in males in the 6 th and 7 th decades of life; whereas, dermatofibroma and post-inflammatory pigmentation were more common in females in the 4 th and 5 th decades of life. Overall, the pigmented skin lesions were more common in the 3 rd , 4 th , and 5 th decades of life with peak in the 4 th decade. Skin of face was the most common site affected by melanocytic nevi and malignant epidermal skin tumors. Conclusions: In conclusion, most of the pigmented skin lesions are benign, encountered in the 4 th decade of life, and commonly affect the skin of face. Also, most of the melanocytic nevi are encountered in females, while most of the malignant epidermal neoplasms are encountered in males affecting the skin of face.

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Tumors of the epidermis

Cited by 65 publications

References 1,958 publications

Raman active components of skin cancer

Raman active components of skin cancer

Queratoacantoma de vulva: presentación de un caso

Common Pigmented Skin Lesions

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