A theoretical approach to the interpretation of the transient data in scanning laser ablation inductively coupled plasma mass spectrometry: Consideration of the geometry of the scanning area

Plotnikov, A. F.; Vogt, Carsten; Wetzig, K.; Kyriakopoulos, Antonios

doi:10.1016/j.sab.2007.12.012

Cited by 21 publications

(14 citation statements)

References 27 publications

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“…When the sample is continuously scanned under the laser beam, the dispersion of the transport system will lead to mixing of the aerosol generated from different positions. The temporal profile of the ion signal intensities in comparison with the actual concentration in the sample is therefore always blurred [100,101]. In general, using a laser pulse repetition rate that ensures the occurrence of the aerosol in the ICP only after the previous cloud has diminished would reduce this effect but lead to exceedingly long analysis times when large samples need to be analyzed.…”

Section: Lateral Profilingmentioning

confidence: 99%

“…As more material is removed from each position, higher signal intensities are achieved as well but the aerosol always contains a mixture of material released from different depths. This may complicate an unambiguous assignment of the respective ion signal intensity or element concentration with a specific position in the sample, when the elemental composition varies substantially with depth [100]. In order to separate contributions from individual laser pulses or spatial positions of the sample in the sample aerosol, mathematical models may be employed.…”

Section: Lateral Profilingmentioning

confidence: 99%

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Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICPMS)

Hattendorf

Günther

2014

Handbook of Spectroscopy

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In laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) the aerosol analyzed by ICPMS is generated by evaporating (ablating) a solid sample by means of a high-energy pulsed laser beam, which is focused on the sample surface. The ability to concentrate laser energy into an area as small as 4 μm in diameter for current equipment enables spatially resolved elemental analysis of major, minor, and trace elements and isotope ratio measurements in almost any solid material [1][2][3][4][5]. The development of this technique started in 1985 when Alan Gray presented the very first attempt at quantitative analysis of geological materials using LA-ICPMS [6]. The general setup of LA-ICPMS has not undergone fundamental changes since this initial configuration, while technical improvements of laser sources, beam delivery optics, and ICPMS instrumentation led to better performance and an increasing range of applications until today. These applications range from geochemical studies over material sciences and technology into biochemical and even medical applications. Forensic studies of many kinds are routinely carried out, and quality control of production processes is an increasing field where this technique is employed. In general, LA-ICPMS is a valuable tool in elemental trace and ultra trace analysis whenever spatially resolved determinations are required or when sample consumption shall be minimized. Even for bulk analysis, LA-ICPMS may be considered as it eliminates the need for sample digestion and minimizes the occurrence of solvent-based spectral interferences, which can be a severe limitation in ICPMS when using conventional solution nebulization.LA-ICPMS basically consists of the following components:• The laser source and beam delivery. Different pulsed lasers are currently available for LA-ICPMS, which primarily differ in wavelength, pulse duration, and pulse energy as well as in beam geometry and energy distribution. The beam delivery in most cases consists of energy adjustment, steering and shaping elements, and an objective for focusing and observation. Beam shaping is carried out toHandbook of Spectroscopy, Second Edition. Edited by Günter Gauglitz and David S. Moore.

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Section: Lateral Profilingmentioning

confidence: 99%

Section: Lateral Profilingmentioning

confidence: 99%

Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICPMS)

Hattendorf

Günther

2014

Handbook of Spectroscopy

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“…Long washout times result in long analysis times when image pixels are generated from the integrated peak area of each resolved laser spot. Analysis times can be reduced by a faster sampling rate, but this leads to mixing of the ablated material from successive laser-sampling spots and requires mathematical deconvolution of the transient signal to separate data from consecutive laser pulses.. Models of the signal response from particle transport processes 22 can be used to implement mathematical corrections to improve the spatial resolution 23,24 but cannot fully resolve spots into discrete pixels. Over-sampling of the material can be employed to further improve spatial resolution beyond the smallest available spot size on commercial ablation systems.…”

Section: Introductionmentioning

confidence: 99%

High-Speed, Integrated Ablation Cell and Dual Concentric Injector Plasma Torch for Laser Ablation-Inductively Coupled Plasma Mass Spectrometry

et al. 2015

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In recent years, laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS) has gained increasing importance for biological analysis, where ultratrace imaging at micrometer resolution is required. However, while undoubtedly a valuable research tool, the washout times and sensitivity of current technology have restricted its routine and clinical application. Long periods between sampling points are required to maintain adequate spatial resolution. Additionally, temporal signal dispersion reduces the signal-to-noise ratio, which is a particular concern when analyzing discrete samples, such as individual particles or cells. This paper describes a novel, two-volume laser ablation cell and integrated ICP torch designed to minimize aerosol dispersion for fast, efficient sample transport. The holistic design utilizes a short, continuous diameter fused silica conduit, which extends from the point of ablation, through the ICP torch, and into the base of the plasma. This arrangement removes the requirement for a dispersive component for argon addition, and helps to keep the sample on axis with the ICP cone orifice. Hence, deposition of sample on the cones is theoretically reduced with a resulting improvement in the absolute sensitivity (counts per unit mole). The system described here achieved washouts of 1.5, 3.2, and 4.9 ms for NIST 612 glass, at full width half, 10%, and 1% maximum, respectively, with an 8–14-fold improvement in absolute sensitivity, compared to a single volume ablation cell. To illustrate the benefits of this performance, the system was applied to a contemporary bioanalytical challenge, specifically the analysis of individual biological cells, demonstrating similar improvements in performance.

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“…En modo "barrido", con la muestra en movimiento, la posición del haz láser va variando con relación a la superficie de la misma y se obtiene el perfil de la distribución de elementos a lo largo y ancho de un área determinada. En modo "punto fijo", con el haz láser focalizado en un punto determinado de la muestra durante un cierto periodo de tiempo, se obtiene el perfil de distribución en profundidad [6] . Adquiriendo señales transitorias durante la ablación de líneas paralelas sobre la superficie de la muestra, se puede obtener una imagen de distribución elemental en un área determinada.…”

Section: Introductionunclassified

Resolución espacial en la ablación láser acoplada a la espectrometría de masas con fuente de plasma de acoplamiento inductivo.

Coedo¹,

Dorado²

2010

REVMETAL

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ResumenLa ablación láser como sistema de introducción de muestra a la espectrometría de masas con fuente de plasma de acoplamiento inductivo (LA-ICP-MS) ofrece la posibilidad de conocer la distribución espacial de los elementos. Variando la posición del haz láser sobre la superficie, se obtiene el perfil de la distribución lateral de elementos y, haciendo incidir sucesivos pulsos sobre un punto fijo, se obtiene el perfil de concentraciones en profundidad. Después de optimizar los parámetros operatorios se ha aplicado la técnica a muestras con distintas composiciones tanto en superficie como en profundidad. Con relación a la resolución lateral se ha comprobado que en una longitud similar al diámetro del cráter del haz láser, las señales de los elementos presentes aparecen mezcladas lo que dificulta establecer con precisión la interfase. En cuanto a la resolución en profundidad se establece claramente la influencia de la abundancia natural de los isótopos medidos. Palabras claveAblación láser; Espectrometría de masas con fuente de plasma de acoplamiento inductivo; Resolución espacial; Muestras soldadas; Muestras metálicas recubiertas. Spatial resolution in laser ablation inductively coupled plasma mass spectrometry AbstractLaser ablation as sampling system in inductively coupled plasma mass spectrometry (LA-ICP-MS) offers the possibility to know the spatial distribution of elements present in a solid sample. By varying the position of the laser beam on the sample surface, the profile of the lateral distribution of elements is obtained and, with successive pulses fired on a fixed point, profile in depth is achieved. After optimization of operating parameters the technique has been applied to samples with different compositions in both surface and depth. With regard to the lateral resolution has been found that in a length similar to the crater diameter of the laser beam, the signals of the elements appear mixed, making difficult to accurately establish the interface. Regarding the resolution in depth is clearly established the influence of the natural abundance of the measured isotopes.

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A theoretical approach to the interpretation of the transient data in scanning laser ablation inductively coupled plasma mass spectrometry: Consideration of the geometry of the scanning area

Cited by 21 publications

References 27 publications

Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICPMS)

Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICPMS)

High-Speed, Integrated Ablation Cell and Dual Concentric Injector Plasma Torch for Laser Ablation-Inductively Coupled Plasma Mass Spectrometry

Resolución espacial en la ablación láser acoplada a la espectrometría de masas con fuente de plasma de acoplamiento inductivo.

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