A systematic review on the association between genetic predisposition and dental implant biological complications

Dereka, Xanthippi; Mardas, Nikos; Chin, Sarah; Petrie, Aviva; Donos, Nikolaos

doi:10.1111/j.1600-0501.2011.02329.x

Cited by 62 publications

(79 citation statements)

References 62 publications

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“…[74][75][76] However, in a systematic review, Dereka and colleagues 77 reported no apparent association between specific genetic polymorphism and dental implant failure in terms of biological complications (peri-implant diseases). Hultin and colleagues, 78 Rogers and colleagues, 79 and Campos and colleagues 80 also reported no association between gene polymorphism and peri-implantitis.…”

Section: Genetic Factorsmentioning

confidence: 99%

Peri-implant Diseases

Romanos

Javed

Delgado-Ruíz

et al. 2015

Dental Clinics of North America

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Section: Genetic Factorsmentioning

confidence: 99%

Peri-implant Diseases

Romanos

Javed

Delgado-Ruíz

et al. 2015

Dental Clinics of North America

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“…A recent systematic review of the association between genetic predisposition and biological complications of dental implants suggested that there is no strong association among specific genetic polymorphisms (IL-1A, IL-1B, IL-17RC) and peri-implantitis, although there was a notable tendency indicating a link between the IL-1 genotype and peri-implantitis [19], [20]. Another study presented MMP-8 and PGE-2, both regulated by IL-1 as possible genetic markers for unsuccessful implants based on their role in regulating the extra cellular matrix (ECM) which may enhance bone healing within defects and promote implant osseointegration [21].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Pathogenic Genes in Peri-Implantitis from Implant Clustering Failure Patients: A Whole-Exome Sequencing Pilot Study

et al. 2014

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Peri-implantitis is a frequently occurring gum disease linked to multi-factorial traits with various environmental and genetic causalities and no known concrete pathogenesis. The varying severity of peri-implantitis among patients with relatively similar environments suggests a genetic aspect which needs to be investigated to understand and regulate the pathogenesis of the disease. Six unrelated individuals with multiple clusterization implant failure due to severe peri-implantitis were chosen for this study. These six individuals had relatively healthy lifestyles, with minimal environmental causalities affecting peri-implantitis. Research was undertaken to investigate pathogenic genes in peri-implantitis albeit with a small number of subjects and incomplete elimination of environmental causalities. Whole-exome sequencing was performed on collected saliva samples via self DNA collection kit. Common variants with minor allele frequencies (MAF) > = 0.05 from all control datasets were eliminated and variants having high and moderate impact and loss of function were used for comparison. Gene set enrichment analysis was performed to reveal functional groups associated with the genetic variants. 2,022 genes were left after filtering against dbSNP, the 1000 Genomes East Asian population, and healthy Korean randomized subsample data (GSK project). 175 (p-value <0.05) out of 927 gene sets were obtained via GSEA (DAVID). The top 10 was chosen (p-value <0.05) from cluster enrichment showing significance of cytoskeleton, cell adhesion, and metal ion binding. Network analysis was applied to find relationships between functional clusters. Among the functional groups, ion metal binding was located in the center of all clusters, indicating dysfunction of regulation in metal ion concentration might affect cell morphology or cell adhesion, resulting in implant failure. This result may demonstrate the feasibility of and provide pilot data for a larger research project aimed at discovering biomarkers for early diagnosis of peri-implantitis.

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“…Various prospective and retrospective analyses have shown that the systemic health of the host (e.g., type II diabetes mellitus) [25], genetic traits [26], environmental factors (e.g., smoking) [27,28], a past history of periodontitis [28], poor compliance with mechanical cleaning recommendations [27], and infrequent dental maintenance visits [29] is major risk factors for the development of peri-implantitis.…”

Section: Biofilm-induced Peri-implant Diseasesmentioning

confidence: 99%

Novel Models to Manage Biofilms on Microtextured Dental Implant Surfaces

Tran¹,

Walsh²

2016

Microbial Biofilms - Importance and Applications

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Dental implants are used extensively to replace missing teeth. To enhance their integration with the bones of the jaws, the surfaces of titanium dental implants are modified to make them hydrophilic, high energy, and microtextured. These same features make biofilm development occur readily upon exposure to the saliva. The presence of mature biofilms on dental implant surfaces drives local inflammatory responses in the adjacent soft and hard tissues (peri-implantitis), which leads to pathological loss of bone and the formation of a saucer shaped bone defects. This chapter examines the unique challenges posed by biofilms formed on highly complex dental implant surfaces, which are difficult to access for cleaning, and easily damaged by conventional cleaning approaches. We explore how biofilms can be removed from implant surfaces using a variety of novel methods, without causing surface damage or other undesirable modifications, and show how different laboratory and clinical models can be used to assess the performance of both conventional and novel methods of biofilm removal.

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A systematic review on the association between genetic predisposition and dental implant biological complications

Cited by 62 publications

References 62 publications

Peri-implant Diseases

Peri-implant Diseases

Investigation of Pathogenic Genes in Peri-Implantitis from Implant Clustering Failure Patients: A Whole-Exome Sequencing Pilot Study

Novel Models to Manage Biofilms on Microtextured Dental Implant Surfaces

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