A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: A systematic review

Almeida, John R. de; Byrd, J. Kenneth; Wu, Rebecca; Stucken, Chaz L.; Duvvuri, Uma; Goldstein, David P.; Miles, Brett A.; Teng, Marita S.; Gupta, Vishal; Genden, Eric M.

doi:10.1002/lary.24712

Cited by 225 publications

(214 citation statements)

References 35 publications

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“…In a comparison of related studies of patients with HPV-positive lower T-stage disease, 2-year survival rates ranged from 91% to 96%, [12][13][14] with one review illustrating pooled 2-year overall survival rates of 82% to 94% following TORS. 15 The risk of significant morbidity from traditional treatment modalities has made minimally invasive surgery attractive in order to potentially reduce functional morbidity.…”

mentioning

confidence: 99%

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Helman¹,

Schwedhelm²,

Kadakia³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context The incidence of oropharyngeal squamous cell carcinoma has increased during the past decade and is related primarily to the human papillomavirus. This change in etiology, from tobacco and alcohol to human papillomavirus, has resulted in improved survival for the disease. In the United States, open resection had largely been replaced by concurrent chemotherapy and/or radiotherapy by the early 2000s. The advent of transoral surgery has led to an increase in surgery as the primary treatment for both early- and advanced-stage oropharyngeal squamous cell carcinoma because it has potential advantages over open surgery and nonsurgical modalities. Objective To provide an overview of transoral robotic surgery for oropharyngeal squamous cell carcinoma and contrast it with other surgical and nonsurgical modalities. Data Sources Articles from 2000 to 2014 were accessioned on PubMed and reviewed for utility by the primary authors. Conclusions Transoral surgery has become more commonly used as a minimally invasive approach to treat oropharyngeal tumors. Other strategies, including radiation, chemotherapy with radiation, and open surgery, are still important treatment approaches. The treatment options for an individual patient rely on multiple factors, including the tumor location and size, features of the tumor, and patient comorbidities. The continued study of these techniques is important to match the patient with the most appropriate treatment.

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mentioning

confidence: 99%

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Helman¹,

Schwedhelm²,

Kadakia³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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“…Thus, when adjuvant treatment is added to TORS, the overall treatment toxicity is increased. Recently, de Almeida et al compared the effectiveness and adverse effects of IMRT (8 series with 1287 patients, 43 % received chemotherapy and 30 % had neck dissection for persistent disease) and TORS (12 series with 772 patients, 26 % had adjuvant RT and 41 % had adjuvant chemoradiation) in early T-stage oropharyngeal SCC and found no difference in the overall survival rates at 2 years between the two treatment modalities [15]. Even though the toxicity seems to be lower in TORS-based studies, bias in the selection of patients for TORS, inherently linked to a nonrandomized comparison, precludes any firm conclusion.…”

Section: Oropharynxmentioning

confidence: 99%

When is definitive radiotherapy the preferred treatment for head and neck squamous cell carcinoma?

Mendenhall

Strojan

Eisbruch

et al. 2015

Eur Arch Otorhinolaryngol

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“…[4] анализ всех доступных опубликованных исследований по ле-чению раннего рака ротоглотки позволил продемонст-рировать сопоставимые результаты 2 лечебных тактик: при лучевом лечении общая 2-летняя выживаемость составила от 84 до 96 % и при хирургическом -от 82 до 94 %. При сравнимой эффективности этих методов главный вопрос -это качество жизни пациента.…”

Section: Introductionunclassified

The First Experience of Transoral Robot-Assisted Surgery in a Patient With Oropharyngeal Cancer (Clinical Observation)

Кропотов¹,

Мосин²,

Petrova³

et al. 2017

Opuholi golovy šei

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Key words: multiple primary tumors, oropharyngeal cancer, robot-assisted surgeryВведение Рак ротоглотки является одной из наиболее частых локализаций плоскоклеточного рака органов головы и шеи. На фоне снижения его общей частоты в мире отмечен рост встречаемости рака ротоглотки, большей частью за счет опухоли, ассоциированной с вирусом папилломы человека [1]. В 2013 г. заболеваемость ра-ком ротоглотки в мире составляла 142 387 случаев (1 % от всей онкологической патологии), в то время как в Российской Федерации -2251 случай (0,43 % от всех злокачественных опухолей) [1,2].В настоящее время существуют различные подходы в лечении рака ротоглотки и основное внимание при выборе оптимального метода сконцентрировано на сохранении формы и функции органа и качестве жизни пациента [3]. При раннем раке ротоглотки воз-можно применение как лучевого, так и хирургическо-го лечения в виде трансоральной лазерной микрохи-рургии либо роботизированной операции.Проведенный J. R. de Almeida и соавт.[4] анализ всех доступных опубликованных исследований по ле-чению раннего рака ротоглотки позволил продемонст-рировать сопоставимые результаты 2 лечебных тактик: при лучевом лечении общая 2-летняя выживаемость составила от 84 до 96 % и при хирургическом -от 82 до 94 %. При сравнимой эффективности этих методов главный вопрос -это качество жизни пациента. В свя-зи с этим некоторые авторы справедливо замечают, что хирургическое вмешательство при лечении рака ротоглотки имеет преимущество в случае, если оно проводится в самостоятельном плане, так как в про-тивном случае комбинация хирургического и химио-

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A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: A systematic review

Abstract: This review suggests that survival estimates are similar between the two modalities and that the differences lie in adverse events.

Cited by 225 publications

References 35 publications

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Transoral Robotic Surgery in Oropharyngeal Carcinoma

When is definitive radiotherapy the preferred treatment for head and neck squamous cell carcinoma?

The First Experience of Transoral Robot-Assisted Surgery in a Patient With Oropharyngeal Cancer (Clinical Observation)

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