A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

Taylor, Drew W.; Petrera, Massimo; Hendry, Mike; Theodoropoulos, John

doi:10.1097/jsm.0b013e31821d0f65

Cited by 205 publications

(135 citation statements)

References 32 publications

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“…To this end, platelet rich plasma (PRP), a natural concentrate of many growth factors [182][183][184], is under intense investigation. PRP has been proposed as a therapy for the treatment of equine tendon injuries, with data demonstrating development and maturation of a healing tendon tissue, based on improved metabolic activity, increased failure strength and elastic modulus of the repairing tissues and increased neovascularisation, over the saline injected counterparts in an equine superficial digital flexor tendon model [185][186][187][188].…”

Section: Delivery Of Biological Molecules -Growth Factorsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

171

184

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Section: Delivery Of Biological Molecules -Growth Factorsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

171

184

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“…It is currently recognized as an effective treatment for diabetic wounds [10], surgical wounds [9], and musculoskeletal injuries [11]. There have been reports of generally positive patient outcomes with a very low occurrence rate of adverse events, and while there have not been a large number of randomized clinical trials performed for some of the desired applications, such as ligament and tendon repair [12], the application of PRP for other conditions such as osteoarthritis has definitively yielded better results than alternatives such as hyaluronic acid [13] and corticosteroids [14].…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

Platelet rich plasma and amnion-derived fluid as clinical options for regenerative medicine applications

Et¹,

Rb²,

Rs³

2017

J Transl Sci

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“…Na Medicina humana ainda há a necessidade de mais estudos prospectivos, randomizados, controlados, duplo cego, e de duração suficiente com os requerimentos necessários para oferecer o poder apropriado. (FOSTER et al, 2009;SANCHEZ et al, 2009;TAYLOR et al, 2011). Na Medicina equina a necessidade de trabalhos com alto nível de evidência e adequado delineamento experimental é ainda mais urgente, dada à escassez de resultados advindos de estudos bem construídos.…”

Section: O Emprego Dos Derivados Sanguíneos Nas Lesões Tendíneas E LIunclassified

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

et al. 2014

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ResumoAs lesões musculoesqueléticas que ocorrem durante a prática esportiva em equinos são debilitantes e demandam um longo período de tratamento e reabilitação, para muitas vezes obter-se após o tratamento apenas um tecido cicatricial, predispondo à recidiva. Em busca de terapias mais efetivas e da reparação tecidual de melhor qualidade, tem sido estudada a utilização de derivados sanguíneos, como plasma rico em plaquetas e soro autólogo condicionado. Apesar de ambos serem considerados hemoderivados, o soro autólogo condicionado e o plasma rico em plaquetas são produtos distintos com indicações totalmente diferentes para seu uso. Em lesões tendíneas e ligamentares o plasma rico em plaquetas apresenta resultado promissor em estudos clínicos e experimentais. Nas lesões osteoarticulares estes resultados são obtidos tanto com o soro autólogo condicionado como com o plasma rico em plaquetas. A presente revisão tem como objetivo apresentar estudos clínicos e experimentais (in vivo e in vitro) na espécie equina, que auxiliem na escolha do melhor hemoderivado a ser utilizado frente às diferentes lesões musculoesqueléticas. Palavras-chave: Plasma rico em plaquetas, soro autólogo condicionado, tendão, ligamento, articulação, músculo AbstractMusculoskeletal injuries that occur in horses during sports activities are often disabling and require a long period of treatment and rehabilitation, most resulting in scar tissue, predisposing to recurrence. In search of more effective therapies and tissue regeneration, studies have been carried out with blood derivatives -platelet rich plasma and autologous conditioned serum. In spite of both being bloodderived therapies, platelet rich plasma and autologous conditioned serum are distinct products, with equally distinct indications for their use. Platelet rich plasma shows promising results in ligament and tendon injuries in clinical and experimental trials. This occurs also in osteoarticular lesions with both hemoderivates, autologous conditioned serum and platelet rich plasma. This review aims to present clinical and experimental studies (in vivo and in vitro) in the equine species, as an aid for an appropriate therapeutic choice, when hemoderivates are considered for treatment of musculoskeletal lesions.

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A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

Abstract: Presently, PRP use in tendon and ligament injuries has several potential advantages, including faster recovery and, possibly, a reduction in recurrence, with no adverse reactions described. However, only 3 randomized clinical trials have been conducted.

Cited by 205 publications

References 32 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Platelet rich plasma and amnion-derived fluid as clinical options for regenerative medicine applications

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

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