A systematic investigation of the bio-toxicity of core-shell magnetic mesoporous silica microspheres using zebrafish model

Nasrallah, Gheyath K.; Zhang, Yu; Zagho, Moustafa M.; Ismail, Hesham M.; Al-Khalaf, Areej A.; Prieto, R.M.; Albinali, Kholoud E.; Elzatahry, Ahmed A.; Deng, Yonghui

doi:10.1016/j.micromeso.2018.02.008

Cited by 29 publications

(9 citation statements)

References 40 publications

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“…[161][162][163][164][165] Core-shell nanocomposites with mesoporous silica have attracted growing interest in recent years. 166 Combining them with a magnetic core leads to benefits including magnetic cores to control these carriers and mesoporous silica to build such efficient vehicles. Using mesoporous silica-based carriers is one of the exciting concepts, where specific materials are designed to be attached on the surface of the mesoporous silica to seal the entrances to the pores to assure minimum leakage of the therapeutic agents.…”

Section: Mnps@mesoporous Silica Core-shell Drug Carriersmentioning

confidence: 99%

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Albinali¹,

Zagho²,

Deng³

et al. 2019

IJN

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Magnetic core–shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core–shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core–shell drug carriers based on Fe 2 O 3 and Fe 3 O 4 as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment.

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Section: Mnps@mesoporous Silica Core-shell Drug Carriersmentioning

confidence: 99%

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Albinali¹,

Zagho²,

Deng³

et al. 2019

IJN

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“…This effect, although with little relevance in MRI and magnetic guidance, needs to be accounted for if Magnetothermal-chemotherapy (MTCT) is intended [ 55 ]. Despite the improved in vivo stability provided by the silica coating of IOMSNs, this outer shell must also be chemically modified to avoid the interaction with adhesive proteins of the immune system [ 56 ]. This could be achieved by any of the conventional coating procedures known for silica: polyethyleneglycol, [ 40 , 57 ] small targeting elements, functional polymers, zwitterions, small-interfering RNAs (siRNAs), deposition and coating with membranes, although none of these materials have yet reached clinical studies, as far as we know ( Figure 2 ).…”

Section: Inorganic-mesoporous Silica Nanocomposites With Magnetic mentioning

confidence: 99%

Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Castillo

Vallet‐Regí

2019

IJMS

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The rise and development of nanotechnology has enabled the creation of a wide number of systems with new and advantageous features to treat cancer. However, in many cases, the lone application of these new nanotherapeutics has proven not to be enough to achieve acceptable therapeutic efficacies. Hence, to avoid these limitations, the scientific community has embarked on the development of single formulations capable of combining functionalities. Among all possible components, silica—either solid or mesoporous—has become of importance as connecting and coating material for these new-generation therapeutic nanodevices. In the present review, the most recent examples of fully inorganic silica-based functional composites are visited, paying particular attention to those with potential biomedical applicability. Additionally, some highlights will be given with respect to their possible biosafety issues based on their chemical composition.

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“…Testing teratogenicity of clinical drugs involves exposing zebrafish embryos to desired concentrations. Due to small size of the embryos, multiple well plates can be used making it possible to test a high number of animals simultaneously [ 12 , 13 , 33 ]. Drug exposure usually begins around 5-hpf, corresponding to late blastula/early gastrula stages and ends at 96-hpf, where most organs are fully developed [ 34 ].…”

Section: Cardiotoxicity Evaluation In Zebrafishmentioning

confidence: 99%

Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

Zakaria

Benslimane

Nasrallah

et al. 2018

BioMed Research International

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Over the last decade, the zebrafish (Danio rerio) has emerged as a model organism for cardiovascular research. Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish is comparatively low; the embryos are transparent, develop externally, and have high fecundity making them suitable for large-scale genetic screening. More recently, zebrafish embryos have been used for the screening of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to exhibit physiological responses that are similar to mammals after exposure to medicinal drugs including xenobiotics, hormones, cancer drugs, and also environmental pollutants, including pesticides and heavy metals. In this review, we provided a summary for recent studies that have used zebrafish to investigate the molecular mechanisms of drug-induced cardiotoxicity. More specifically, we focused on the techniques that were exploited by us and others for cardiovascular toxicity assessment and described several microscopic imaging and analysis protocols that are being used for the estimation of a variety of cardiac hemodynamic parameters.

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A systematic investigation of the bio-toxicity of core-shell magnetic mesoporous silica microspheres using zebrafish model

Cited by 29 publications

References 40 publications

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

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A systematic investigation of the bio-toxicity of core-shell magnetic mesoporous silica microspheres using zebrafish model

Cited by 29 publications

References 40 publications

<p>A perspective on magnetic core&ndash;shell carriers for responsive and targeted drug delivery systems</p>

<p>A perspective on magnetic core&ndash;shell carriers for responsive and targeted drug delivery systems</p>

Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

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<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>