Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Castillo, Rafael R.; Vallet‐Regí, María

doi:10.3390/ijms20040929

Cited by 49 publications

(26 citation statements)

References 201 publications

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“…Subcutaneous injections have shown a preventive effect with a decreased Th2 response and boosted Th1 immunity with elevated allergen-specific IgG levels (264). However, safety of inorganic nanoparticles is still under debate and this may prevent implementation of this method in the clinic (265).…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease

et al. 2020

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Humans have always been in contact with natural airborne particles from many sources including biologic particulate matter (PM) which can exhibit allergenic properties. With industrialization, anthropogenic and combustion-derived particles have become a major fraction. Currently, an ever-growing number of diverse and innovative materials containing engineered nanoparticles (NPs) are being developed with great expectations in technology and medicine. Nanomaterials have entered everyday products including cosmetics, textiles, electronics, sports equipment, as well as food, and food packaging. As part of natural evolution humans have adapted to the exposure to particulate matter, aiming to protect the individual's integrity and health. At the respiratory barrier, complications can arise, when allergic sensitization and pulmonary diseases occur in response to particle exposure. Particulate matter in the form of plant pollen, dust mites feces, animal dander, but also aerosols arising from industrial processes in occupational settings including diverse mixtures thereof can exert such effects. This review article gives an overview of the allergic immune response and addresses specifically the mechanisms of particulates in the context of allergic sensitization, effector function and therapy. In regard of the first theme (i), an overview on exposure to particulates and the functionalities of the relevant immune cells involved in allergic sensitization as well as their interactions in innate and adaptive responses are described. As relevant for human disease, we aim to outline (ii) the potential effector mechanisms that lead to the aggravation of an ongoing immune deviation (such as asthma, chronic obstructive pulmonary disease, etc.) by inhaled particulates, including NPs. Even though adverse effects can be exerted by (nano)particles, leading to allergic sensitization, and the exacerbation of allergic symptoms, promising potential has been shown for their use in (iii) therapeutic approaches of allergic disease, for example as adjuvants. Hence, allergen-specific immunotherapy (AIT) is introduced and the role of adjuvants such as alum as well as the current understanding of their mechanisms of action is reviewed. Finally, future prospects of nanomedicines in allergy treatment are described, which involve modern platform technologies combining immunomodulatory effects at several (immuno-)functional levels.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease

et al. 2020

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“…Besides their known possibilities as conventional drug delivery carriers, MSNs and related hybrid particles are suitable candidates for incorporating most of nanotechnological breakthroughs, as will be reviewed along the manuscript. In fact, mesoporous silica has gone beyond being a simple material for building nanoparticles, it has become a widespread material for connecting different units into multifunctional and degradable nanocomposites [9]. Beyond those advantages, MSNs can be fabricated in a relative large-scale synthesis showing a great variety of morphologies and functionalities, thus widening the range of possibilities in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Castillo

Lozano

González

et al. 2019

Expert Opinion on Drug Delivery

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128

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Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This review summarizes the scientific advances dealing with MSNs for targeted and stimuli-responsive drug delivery since 2015. Delivery aspects to diseased tissues together with approaches to obtain smart MSNs able to respond to internal or external stimuli and their applications are here described. Special emphasis is done on the combination of two or more stimuli on the same nanoplatform and on combined drug therapy. Expert opinion: The use of MSNs in nanomedicine is a promising research field because they are outstanding platforms for treating different pathologies. This is possible thanks to their structural, chemical, physical and biological properties. However, there are certain issues that should be overcome to improve the suitability of MSNs for clinical applications. All materials must be properly characterized prior to their in vivo evaluation; furthermore, preclinical in vivo studies need to be standardized to demonstrate the MSNs clinical translation potential.

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“…For instance, folate receptors (FRs) exhibit limited expression on healthy cells, but are overexpressed on cancer cells in ovary, mammary gland, colon, lung, prostate, nose, throat, and brain [ 56 , 57 ]. Therefore functionalization of silica nanoparticles with folic acid (FA) turns them into highly selective sensors of cancer cells [ 43 , 53 , 54 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells

Prieto-Montero

Katsumiti

Cajaraville

et al. 2020

Sensors

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Functionalized fluorescent silica nanoparticles were designed and synthesized to selectively target cancer cells for bioimaging analysis. The synthesis method and characterization of functionalized fluorescent silica nanoparticles (50–60 nm), as well as internalization and subcellular localization in HeLa cells is reported here. The dye, rhodamine 101 (R101) was physically embedded during the sol–gel synthesis. The dye loading was optimized by varying the synthesis conditions (temperature and dye concentration added to the gel) and by the use of different organotriethoxysilanes as a second silica precursor. Additionally, R101, was also covalently bound to the functionalized external surface of the silica nanoparticles. The quantum yields of the dye-doped silica nanoparticles range from 0.25 to 0.50 and demonstrated an enhanced brightness of 230–260 fold respect to the free dye in solution. The shell of the nanoparticles was further decorated with PEG of 2000 Da and folic acid (FA) to ensure good stability in water and to enhance selectivity to cancer cells, respectively. In vitro assays with HeLa cells showed that fluorescent nanoparticles were internalized by cells accumulating exclusively into lysosomes. Quantitative analysis showed a significantly higher accumulation of FA functionalized fluorescent silica nanoparticles compared to nanoparticles without FA, proving that the former may represent good candidates for targeting cancer cells.

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Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.

Cited by 49 publications

References 201 publications

Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease

Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells

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