A Systematic Analysis of Relationships Between Biochemical Indices in Persons Exposed to Mercury

Kudaeva, Irina V.; Masnavieva, L. B.; Naumova, O. V.; Dyakovich, O. A.

doi:10.18821/0016-9900-2018-97-10-990-994

Cited by 3 publications

(2 citation statements)

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“…We revealed involvement in the pathological process of the formation of disorders of the nervous system during mercury intoxication of changes in the level of NA. Its effect associated with a predominant effect on α-adrenergic receptors, participating in the pathogenesis of arterial hypertension (AH), recorded in most individuals exposed to mercury (Figure 1) [7]. It should also be taken into account that under the conditions of activation of oxidative stress processes catecholamines and other compounds undergo oxidation under the action of ceruloplasmin, contributing to the further activation of oxidative processes.…”

Section: Discussionmentioning

confidence: 99%

“…The resulting dysfunction of noradrenaline (NA) affects a wide range of neurons of central nervous system (CNS) and can cause a number of neurodegenerative (Alzheimer's, Parkinson's and motor neurons), demyelinating (multiple sclerosis) and psychiatric conditions (severe depression and bipolar disorder). It was also established that neurochemical changes in individuals, exposed to mercury, are characterized by the increase of the NA concentration in the distant period of intoxication, and increased levels of dopamine (DA), serotonin (SER) and histamine (HIST) [7].…”

Section: Introductionmentioning

confidence: 99%

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The role of neurochemical factors in the chronic mercury intoxication development

et al. 2020

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The search of pathogenetic targets for the diagnosis and treatment of mercury intoxication is an actual problem. The aim of the investigation was to study the dynamics of changes in neurochemical parameters in workers in contact with mercury and in persons in the early and distant period of intoxication. A prospective cohort examination included 69 men, exposed to mercury vapors in the workplace (1) and 36 patients in the distant (2) and 18 – in initial period of chronic mercury intoxication (3). Serotonin, histamine, catecholamines and their metabolites were determined in blood plasma. The maximum number of indicators that changed in the dynamics of the survey was registered in the group 2. Dopamine level increased by a maximum value - 284%, noradrenaline - 124%. Only the noradrenaline content changed in 3.2 times in patients in the group 3 and in 1.4 times in experienced workers without pathology. This changes in experienced workers was partially offset by its transition to inactive metabolite normetanephrine. The increase of noradrenaline concentration was not accompanied by increase of its metabolite level in the group 3. But the increase of the dopamine, serotonin and histamine joined in the distant period of chronic mercury intoxication.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of neurochemical factors in the chronic mercury intoxication development

et al. 2020

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The role of neurotransmitters and indicators of oxidative stress in the formation of disorders of central conductive structures in patients who came into contact with metallic mercury

Rusanova

Лахман

Kudaeva

et al. 2022

Med. tr. prom. èkol.

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Introduction. Studies of toxic lesions due to exposure to metallic mercury compounds do not allow us to identify the features of the violation of central afferent conducting structures in the long-term period of chronic mercury intoxication (CHMI). The contribution of various systems to the development of pathology is not sufficiently disclosed. The study aims to identify the role of neurotransmitters in pathological changes in central hemodynamics, the value of lipid peroxidation products and the activity of antioxidant protection in the demyelination of central afferent conductive structures in workers exposed to metallic mercury in the workplace. Materials and methods. The authors examined 47 people (group one) - trained chemical production workers exposed to metallic mercury, and group two (51 people) - patients in the long-term period of CHMI. The control group (CG) consisted of 30 people who had no contact with toxicants. We have determined concentration of neurotransmitters, lipid peroxidation products (LPP), superoxide dismutase (SOD) and reduced glutathione (RG), nitric oxide. Results. Experts observed statistically significant changes in indicators in subgroups with and without changes in cerebral hemodynamics and in group two when compared with group one. Comparison of persons with CHMI without changes in blood circulation with the presence of disorders revealed an increase in normetanephrine in the latter, a decrease in NT-3. Correlation analysis showed: in group jne, there was a statistically significant difference between the vasomotor reactivity index (VRI) and serotonin. In group two - between CHMI and serotonin, adrenaline and dopamine. Changes in afferent pathways are interrelated with indicators of oxidative stress. Violations are accompanied by the formation of a pathological system, are signs of dysregulatory pathology. Limitations. The disadvantage of the study is the fact that scientists determined the content of neurotransmitters and products of lipid peroxidation and antioxidant protection in the blood of the subjects, and not in the structures of the brain. Conclusion. The increased content of biogenic amines leads to a change in peripheral blood circulation and regulation of cerebral blood flow by pressor action on the regulation of the vascular bed, leading to vasoconstriction, changes in the bioelectric activity of the structures of the reticular formation of the midbrain, hypothalamus, thalamocortical structures, most pronounced in the long-term period of chronic mercury intoxication. We found that the formation of demyelination in patients with chronic mercury intoxication was accompanied by a decrease in the concentration of NT-3. It was natural to reduce the level of reduced glutathione and superoxide dismutase in neurodegenerative processes in trained workers exposed to metallic mercury at work, and in patients with a long period of chronic mercury intoxication. Ethics. The study was conducted in compliance with the principles of the Helsinki Declaration of the World Association "Ethical principles of conducting Scientific medical research with human participation" (as amended in 2008), "Rules of Clinical Practice in the Russian Federation" (approved by the Order of the Ministry of Health of the Russian Federation dated 06/19/2003 No. 266).

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The state of lipid exchange in persons living in the territory of environmental illusion

Kudaeva,

Lysenko

2023

Hygiene and Sanitation

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Introduction. Currently, it is important to consider the issues of diagnosing nonspecific disorders occurred due to exposure of residents to chemicals in cities with chemical industry enterprises on the territory. Materials and methods. Working 30–60 year men, permanently residing downwind from the industrial site of LLC “Usolekhimprom” in the territory exposed to mercury in the city of Usolye-Sibirskoye, were examined. Results. The maximum concentration of total cholesterol (TCH) was 8.7 mmol/L, cholesterol (CH) of low density lipoproteins (LDL) – 6.0 mmol/L, triglycerides (TG) – 2.3 mmol/L, phospholipids – 5.5 mmol/L. The minimum content of high-density lipoprotein cholesterol (HDL cholesterol) was 0.5 mmol/L. In terms of the prevalence of disorders, hypercholesterolemia held the first place – 63% of cases, the second – a high level of LDL cholesterol – 59%, the third – an increase in ApoB – 45%. Hyperphospholipidemia occurred in 35%, hypertriglyceridemia – in 23%. Reduced HDL cholesterol was recorded in 5.3%. Low concentration of Apo A1 was registered in 20% of cases. A high level of atherogenic index was common among 16%. The prevalence of high LDL-CH was consistent with that of hypercholesterolemia, as evidenced by the correlation coefficient between the indices (R=0.77) and between the level of TCH and Apo B (R=0.80). A HDL cholesterol high level does not always indicate the antiatherogenic ability of lipoproteins, and therefore the revealed low prevalence of hypoalphacholesterolemia in the examined individuals (lower than in Russia - 16%) does not indicate antiatherogenic changes. The triglyceridemia level was associated with the ApoB concentration, which indicates its contribution to the development of proatherogenic disorders. A possible mechanism of hyperphospholipidemia is the formation of a compensatory-adaptive stimulus to the phospholipids synthesis in response to hypercholesterolemia and hypertriglyceridemia. Limitations. Male persons. Age 30–60 years. Conclusion. In persons living in the ecological trouble zone, a high frequency of lipid metabolism disorders was revealed. This fact can be considered as one of the main predisposing factors for the development of cardiovascular diseases in this cohort.

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A Systematic Analysis of Relationships Between Biochemical Indices in Persons Exposed to Mercury

Cited by 3 publications

References 15 publications

The role of neurochemical factors in the chronic mercury intoxication development

The role of neurochemical factors in the chronic mercury intoxication development

The role of neurotransmitters and indicators of oxidative stress in the formation of disorders of central conductive structures in patients who came into contact with metallic mercury

The state of lipid exchange in persons living in the territory of environmental illusion

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