Introduction. Changes in biochemical indices characterizing the state of lipid peroxidation processes - antioxidant protection and lipid metabolism are observed during the occupational contact with mercury. These changes play a certain pathogenic role in the formation of disorders in the nervous system during mercury intoxication. In this regard, the aim was to study the relationship between biochemical indices at different stages of the development of mercury intoxication to justify approaches to therapeutic and preventive measures. Material and methods. A prospective cohort examination of persons exposed to the mercury vapor with signs of disorders in the nervous system, patients with chronic mercury intoxication and working in contact with mercury more than 5 years without signs of pathology was carried out. To study the relationship of features between biochemical indices, the sum of the square of correlation relations between the indices was calculated, the ranks of the influence of the system components on other factors and their dependencies were determined. Results. The decline in the level of nitric oxide metabolites was found to be one of the initial, long-term persisting in the pathogenesis of biochemical abnormalities, formed due to the contact with mercury. The development of the nervous system pathology under the mercury influence is accompanied by a change in the ratio of pro- and anti- oxidative processes, lipid metabolism disorders have an independent pathogenic significance. The long-term period of the chronic mercury intoxication is characterized by the formation of complex relationships in the biochemical system, the presence of several closed subsystems, which include nitrogen oxide metabolites. Conclusion. Given peculiarities of systemic interactions between biochemical indices, determining the role of certain factors in the overall system, as well as the presence/absence and composition of subsystems, pathogenic approaches to the correction of metabolic disorders at various stages of the mercury intoxication formation should be different.
The metabolic test with antipyrine was performed, the relationship between genotypes of GSTT1 and GSTM1 polymorphisms were studied, and cotinine level was measured in 116 men chronically exposed to mercury. The individuals were divided in 4 groups depending on the diagnosis of chronic mercury intoxication. The changes in the parameters of antipyrine test were studied in linked samples (N=62, 4 year interval); in patients with chronic mercury intoxication, the disease stage was taken into account. Inhibition of antipyrine metabolism, increased frequency of combination of GSTT1(0/0)/GSTM1(+) genotypes in patients with chronic mercury intoxication, and the specificity of cytochrome P450 inhibition with mercury suggest that disease progression is related to inhibition of cytochrome P450 isoforms in the brain that catalyze regulation of endogenous substrates.
Introduction: Diabetes mellitus (DM) and metabolic syndrome (MS) are characterized by development of atherosclerosis and cardiovascular pathology. Vibration disease (VD) affects oxidative metabolism leading to the development of microangiopathies. However, the evidence on the combined effect of VD and DM or MS on oxidative modification of lipids remains limited. Aim: To study oxidative modification of lipoproteins in individuals with vibrationa disease and metabolic disorders. Metods: In total, 59 patients with VD (group I), 73 people with VD combined with MS (group II) and 35 people with VD and type 2 diabetes (group III) took part in the study. We assessed concentrations of total cholesterol, low density lipoproteins (LDL), oxidized low density lipoproteins (oxLDL), antibodies to oxLDL and thiol status. Results: Serum levels of total cholesterol, oxLDL and antibodies to oxLDL in all groups exceeded the reference values. The proportion of people with a high content of oxLDL varied between 61 % to 72 %. Increased levels of antibodies to oxLDL were observed in 63 % - 85 % of patients in all groups. The concentration of LDL cholesterol was the highest in group II: 3,6 (3,2-4,2) mM/l. Concentrations of oxLDL correlated with the levels of total cholesterol and LDL cholesterol. Lower thiol concentrations were found in 57 % of cases in group II). Conclusion: Our results suggest that individuals with VD have hypercholesterinemia, increased oxidative lipid metabolism and increased production of antibodies to oxLDL independently of metabolic disorders Patients with VD and type 2 diabetes may have decrease antioxidant defense.
Introduction. Endothelial dysfunction (ED) is an important link in the development of cardiovascular disease. There is evidence that exposure to mercury and its compounds can be a risk factor for the development of ED. The aim - the study of endothelial dysfunction markers involved in the regulation of vascular tone, inflammation, and vascular endothelial damage in patients with cardiovascular disease, the exposed and unexposed mercury. Material and Methods. In persons exposed due to their occupational activities with metallic mercury, who had been working for over five years, people with newly diagnosed chronic mercury intoxication and patients with chronic mercury intoxication in the long post-exposure period, and the persons are not exposed mercury a cross-sectional survey was conducted using biochemical methods Results. In examinees there have been revealed changes in the content of biochemical indices of ED - reducing nitrogen oxide, an elevated level of endothelin-1, angiotensin II, histamine, hsCRP, homocysteine. There has been established a breach in the content of ED markers that are pathogenic factors in the development of ED and, as a consequence, the development of cardiovascular disease in chronic mercury exposure. Conclusion. In persons exposed to mercury there were the most pronounced changes in the regulation of vascular tone, which may be one of the factors in the development of vascular disease. At the same time the importance of inflammation indices and vascular endothelial damage plays a secondary role.
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