A synthetic aragonite-based ceramic as a bone graft substitute and substrate for antibiotics

Lucas, Anita; Gaude, J.; Carel, C.; Michel, J.-F; Cathelineau, Guy

doi:10.1016/s1466-6049(00)00058-1

Cited by 50 publications

(37 citation statements)

References 25 publications

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“…Needle-shaped CaCO 3 particles are synthesized by precipitation reaction of potassium hydrogen carbonate (KHCO 3 , Merck) and CaCl 2 (23). Equal volume of 0.1 M KHCO 3 and CaCl 2 are heated until boiling separately.…”

Section: Experimental Preparationmentioning

confidence: 99%

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

2009

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Abstract. The shape effects of dry particles on flowability, aerosolization, and deposition properties in inhalation drug delivery are studied. The properties are compared with similar size range particles of different shapes such as sphere, needle, cube, plate, and pollen. Flowability of the particles is characterized by Carr's compressibility index and angle of slide (θ) method. The aerosolization and deposition properties of the particles are studied in vitro using an eight-stage Anderson cascade impactor with a Rotahaler®. Pollen-shaped particles are found to exhibit better flowability, higher emitted dose, and higher fine particle fraction than particles of other shapes in similar size range. They showed minimum θ of 35°and maximum emitted dose of 87% and fine particle fraction of 16%. The use of pollen-shaped particles can be a potential improvement in dry particle inhalation.

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Section: Experimental Preparationmentioning

confidence: 99%

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

2009

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“…Among biocompatible materials like calcium carbonate [1][2][3][4][5][6][7], calcium phosphate [8][9][10][11], aluminosilicate (geopolymers) [12][13][14] and Bioglass 1 [15][16][17], some of them, known as bioactive, are able to form an apatite-like layer on their surfaces when in contact with simulated body fluid (SBF) in vitro [18][19][20][21] or with physiological fluid in vivo [8,22,23]. This apatite-like layer, associated with bioreactivity [22], is speculated to be responsible for bone bonding [16,23].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the surface reactivity of a sol–gel derived glass in the ternary system SiO2–CaO–P2O5

Mami

Lucas‐Girot

Oudadesse

et al. 2008

Applied Surface Science

102

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“…Moreover, cements, unlike materials obtained by high temperature sintering or natural materials, can be intimately associated with biologically active molecules (specific proteins, antibiotics, etc.) to improve bone reconstruction [43][44].…”

Section: Introductionmentioning

confidence: 99%

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

116

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The feasibility of making calcium carbonate-calcium phosphate (CaCO 3 -CaP) mixed cements, comprising at least 40 % (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated.Several original cement compositions were obtained by mixing metastable crystalline calcium carbonate phases with metastable amorphous or crystalline calcium phosphate powders in aqueous medium. The cements set within at most 1 hour at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the mestastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite (PCA) analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than the apatite formed in the welldeveloped calcium phosphate cements might be of interest to increase resorption rates in biomedical cement and favor its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 -CaP mixed cement compositions.

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A synthetic aragonite-based ceramic as a bone graft substitute and substrate for antibiotics

Cited by 50 publications

References 25 publications

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

Investigation of the surface reactivity of a sol–gel derived glass in the ternary system SiO2–CaO–P2O5

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

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