Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

Hassan, Meer Saiful; Lau, Raymond

doi:10.1208/s12249-009-9313-3

Cited by 125 publications

(91 citation statements)

References 28 publications

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“…The tap density decreases as the particle shape deviates more and more from the sphere [42]. Experimental studies indeed showed that the tap density of spheres has the highest value while the needle-shaped particles had the lowest tap density among cylinder, cube and needleshaped particles [43,44].…”

Section: Tap Densities Of Limnpo 4 and Its Compositesmentioning

confidence: 99%

Nanoparticle shapes of LiMnPO4, Li+ diffusion orientation and diffusion coefficients for high volumetric energy Li+ ion cathodes

Kwon

Yin

Vavrova

et al. 2017

Journal of Power Sources

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h i g h l i g h t s g r a p h i c a l a b s t r a c tNanoparticles of LiMnPO 4 were fabricated in rod, elongated as well as cubic shapes. The 1D Li þ preferred diffusion direction for each shape was determined via electron diffraction spot patterns. The shape of nano-LiMnPO 4 varied the diffusion coefficient of Li þ because the Li þ diffusion direction and the path length were different. The particles with the shortest dimension along the b-axis provided the highest diffusion coefficient, resulting in the highest gravimetric capacity of 135, 100 and 60 mAh g À1 at 0.05C, 1C and 10C, respectively. Using ball-milling, a higher loading of nano-LiMnPO 4 in the electrode was achieved, increasing the volumetric capacity to 263 mAh cm À3 , which is ca. 3.5 times higher than the one obtained by hand-mixing of electrode materials. Thus, the electrochemical performance is governed by both the diffusion coefficient of Li þ , which is dependent on the shape of LiMnPO 4 nanoparticles and the secondary composite structure.

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Section: Tap Densities Of Limnpo 4 and Its Compositesmentioning

confidence: 99%

Nanoparticle shapes of LiMnPO4, Li+ diffusion orientation and diffusion coefficients for high volumetric energy Li+ ion cathodes

Kwon

Yin

Vavrova

et al. 2017

Journal of Power Sources

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show abstract

“…They can also penetrate deeply into body organs and remain in the body for a long time (Balasubramanian et al 2010). It has been shown that the morphology of the soot agglomerates plays an important role in their effects on climate (Scarnato et al 2013) and human health (Hassan and Lau 2009).…”

Section: Introductionmentioning

confidence: 99%

Effective Density and Volatility of Particles Emitted from Gasoline Direct Injection Vehicles and Implications for Particle Mass Measurement

Momenimovahed

Olfert

2015

Aerosol Science and Technology

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The effective density and volatility of particulate emissions from five gasoline direct injection (GDI) passenger vehicles were measured using a tandem differential mobility analyzer (DMA) and centrifugal particle mass analyzer (CPMA) system. The measurements were conducted on a chassis dynamometer at three steady-state operating conditions. A thermodenuder was employed to find the volatility and mixing state of the particles as well as the effective density of nascent and non-volatile particles (defined as particle phase remaining after denuding at 200 C). The mass-mobility exponent ranged between 2.4 and 2.7 for nascent (or undenuded) particles and between 2.5 and 2.7 for non-volatile particles; higher than typical diesel soot. The effective density function was 4278d m ¡0.438 § 76.3 kg/m 3 (for mobility diameter, d m , in nm) for nascent particles and 3215d m ¡0.395 § 37.9 kg/m 3 for non-volatile particles. The effective density functions of the non-volatile particles were fairly similar for the conditions studied. The uncertainty in using the effective density and mixing state data to determine the mass concentration of the aerosol by integrating mobility size distributions was examined. The uncertainty in mass concentration is minimized when only the non-volatile component is measured. However, the uncertainty in the mass concentration increases substantially if nascent particles are measured due to uncertainties in the particle mixing state and their associated effective densities. Furthermore, transient vehicle operation (cold-starts, accelerations, and decelerations) would likely change the mixing state of the exhaust particles suggesting it is difficult to accurately measure the mass concentration of undenuded GDI exhaust particulate using integrated size distribution methods.

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“…However, a shape-dependent difference in aerosol deposition pattern was observed. Previous report has shown that elongated and pollen-shaped particles tend to exhibit better flowability and higher FPF than spherical particles (40). This is because elongated particles have longer suspended time in the air and can travel further in the lung airways (40).…”

Section: Discussionmentioning

confidence: 97%

Self-Associated Submicron IgG1 Particles for Pulmonary Delivery: Effects of Non-ionic Surfactants on Size, Shape, Stability, and Aerosol Performance

Srinivasan

Shoyele

2012

AAPS PharmSciTech

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Abstract. The ability to produce submicron particles of monoclonal antibodies of different sizes and shapes would enhance their application to pulmonary delivery. Although non-ionic surfactants are widely used as stabilizers in protein formulations, we hypothesized that non-ionic surfactants will affect the shape and size of submicron IgG particles manufactured through precipitation. Submicron particles of IgG1 were produced by a precipitation process which explores the fact that proteins have minimum solubility but maximum precipitation at the isoelectric point. Non-ionic surfactants were used for size and shape control, and as stabilizing agents. Aerosol performance of the antibody nanoparticles was assessed using Andersen Cascade Impactor. Spinhaler® and Handihaler® were used as model DPI devices. SEM micrographs revealed that the shape of the submicron particles was altered by varying the type of surfactant added to the precipitating medium. Particle size as measured by dynamic light scattering was also varied based on the type and concentration of the surfactant. The surfactants were able to stabilize the IgG during the precipitation process. Polyhedral, sponge-like, and spherical nanoparticles demonstrated improved aerosolization properties compared to irregularly shaped (>20 μm) unprocessed particles. Stable antibody submicron particles of different shapes and sizes were prepared. Careful control of the shape of such particles is critical to ensuring optimized lung delivery by dry powder inhalation.

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Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

Cited by 125 publications

References 28 publications

Nanoparticle shapes of LiMnPO4, Li+ diffusion orientation and diffusion coefficients for high volumetric energy Li+ ion cathodes

Nanoparticle shapes of LiMnPO4, Li+ diffusion orientation and diffusion coefficients for high volumetric energy Li+ ion cathodes

Effective Density and Volatility of Particles Emitted from Gasoline Direct Injection Vehicles and Implications for Particle Mass Measurement

Self-Associated Submicron IgG1 Particles for Pulmonary Delivery: Effects of Non-ionic Surfactants on Size, Shape, Stability, and Aerosol Performance

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