I am grateful to the individuals that participated in the clinical studies described in this thesis. I would like to thank them for their patience, generosity, and courage. Thanks to Dr. Udo Weishmann his mentorship and input while I carried out this project; our initial fortuitous meeting was to make-way for this influential collaboration. Thanks, Udo, for sharing the passion to help epilepsy patients which has motivated us throughout. Thanks to Becky Higginbottom and Amy Ibbotson, and all the Clinical Physiologists' at the Walton Centre for assisting me with patient profile collection and teaching me valuable epilepsy terminology and the methods at the Neurophysiology Department.Thanks to the NRES committee London-Dulwich (HEALTH RESEARCH AUTHORITY) for supporting me in the design of clinical studies, and for helping me with the NHS IRAS (Integrated Research Approval System). Thanks to Dave Watling for making the ethical aspects of the studies at The Walton Centre possible. The App system used in these studies could not have been built without the help of my colleague and fellow PhD researcher Oladotun Omosebi: his determination, positivity and skill will long live in the memory. I am hugely thankful for the input from my supervisory team; Professor