A survey on chronic rhinosinusitis: opinions from experts of 50 countries

Abstract

Chronic rhinosinusitis (CRS) is a very prevalent inflammatory disease. Treatments vary in different countries. In the present study, we explored the approaches of physicians in 50 countries. In this cross-sectional study, a rhinosinusitis survey (RSS) was completed by Honorary and Corresponding Members (otorhinolaryngologists) of the Italian Society of Rhinology. In 79.1 % of the 50 countries, the proportion of patients suffering from CRS was 15 %. Nasal symptoms were more intense in winter (46 % of countries), and spring and autumn (22 %). The most common symptoms were nasal obstruction (86 %), postnasal drip (82 %) and headache (52 %). The most common investigative modalities in the assessment of CRS are paranasal sinus CT, fiberoptic endoscopy, and anterior rhinoscopy. CRS patients were principally treated by otorhinolaryngologists (70 %). Medical treatments included nasal corticosteroids (90 %), nasal washes (68 %), and nasal decongestants (32 %). In 88 % of countries, more than 50 %, or "about 50 %", of all patients reported subjective symptom improvement after treatment. In most of the countries, surgery was required by 20-35 % of all CRS patients. During post-surgery follow-up, nasal washes (90 %), nasal corticosteroids (76 %), and systemic antibiotics (32 %) were prescribed. In 20-40 % of all patients, CRS was associated with nasal polyps. In such patients, the medical treatment options were nasal corticosteroids (90 %), systemic corticosteroids (50 %), nasal washes (46 %), and systemic antibiotics (34 %). Treatment of CRS patients varies in different countries. Paranasal sinus CT is the most common investigative modality in the assessment of CRS, and nasal corticosteroids are the first-line treatment, in the absence or presence of nasal polyps.

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Dupilumab in Healthy Adult Subjects

“…Asthma affects approximately 300 million people worldwide, 3 and the prevalence of AD has tripled in industrialized countries during the past 3 decades, with up to 30% of children and 10% of adults being affected 4 . Similarly, chronic rhinosinusitis has been reported to affect approximately 15% of the general population, of whom 20% to 40% have concomitant nasal polyposis, 5 and eosinophilic esophagitis has a prevalence of 13‐49 per 100 000 and an incidence of new cases up to 20 per 100 000 per year 6 . In addition to causing significant health problems for sufferers, type 2 diseases are associated with significant social and economic burdens 3,7‐9 .…”

Is Nasal Endoscopy of Diagnostic Value in Chronic Rhinosinusitis Without Nasal Polyps?

“…9 Computed tomography scan is considered the gold standard, with respect to the diagnosis of CRS, and is the most common investigative tool in CRS assessment. 10 However, utilizing CT to confirm the diagnosis of CRS might be misleading at times as well. Several studies failed to show a valid correlation between CRS symptoms and severity on the basis of CT scores.…”

Prevalence and Risk Factor of Chronic Rhinosinusitis and the Impact on Quality of Life in Students of the Medical Faculty Christian University of Indonesia in 2018

“…Research on the prevalence of CRS has been widely carried out throughout the world. Rhinosinusitis and Nasal Polyps (EPOS), it is estimated that CRS affects 5-15% of the adult population in Europe and the United States, with a physician-diagnosed prevalence of 2-4% 16 . In Indonesia, the prevalence study at the ENT-KL polyclinic RSUD dr. Zainoel Abidin in 2012 obtained as many as 33 young and adult patients experiencing chronic rhinosinusitis, with a ratio of 14 men (42.4%) and 19 women (57.6%) 4 .…”