A Surgical Reentry Study on the Influence of Platelet‐Rich Plasma in Enhancing the Regenerative Effects of Bovine Porous Bone Mineral and Guided Tissue Regeneration in the Treatment of Intrabony Defects in Humans

Camargo, Paulo M.; Lekovic, Vojislav; Weinlaender, Michael; Divnic‐Resnik, Tihana; Pavlović, Marija; Kenney, E. Barrie

doi:10.1902/jop.2009.080600

Cited by 53 publications

(45 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, comparison between the two groups revealed no statistically significant difference in the reduction of radiographic defect depth or the defect fill when measured at 6 and 9 months respectively. The results of this inter group comparison were found to be similar to the results of previously conducted studies by Camargo PM et al, (2009) [40] and Saini N et al, (2011) [35], where they found significant improvement in the test sites as compared to control sites in defect depth reduction and bone fill. Significant improvement in clinical and radiological parameters both at test and control sites may also be attributed to the physical characteristic of the regenerative materials used.…”

Section: Discussionsupporting

confidence: 88%

“…Similar results on comparison between two groups were obtained in previous studies [23,24,[31][32][33][34], but contradictory results were found by Saini N et al, (2011), where there was significant reduction in PPD in test group compared to control group [35].…”

Section: Discussionsupporting

confidence: 86%

“…Till date, there are no studies on PRP combined with Biograft-HT. However, the results of our study compare favorably with other studies with PRP combined with other alloplasts [23] and bovine porous bone mineral [30,31].…”

Section: Discussionsupporting

confidence: 79%

See 2 more Smart Citations

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

Shetty¹,

Bose²

2013

J Regen Med Tissue Eng

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

Shetty¹,

Bose²

2013

J Regen Med Tissue Eng

View full text Add to dashboard Cite

“…The activity of a bioactive glass graft material (Demir et al 2007), of a b-tricalcium phosphate graft (Dori et al 2008) as well as of a bovine porous bone mineral graft with and without a membrane barrier (Camargo et al 2009) has not been positively influenced by the presence of PRP.…”

Section: Discussionmentioning

confidence: 99%

The effect of platelet-rich plasma (PRP) combined with a bone allograft on human periodontal ligament (PDL) cells

et al. 2010

View full text Add to dashboard Cite

The prominent purpose of the study was the evaluation of the in vitro mitogenic effect of three different homologous platelet-rich plasma (PRP) preparations (PRPa, PRPb, PRPc) on three different lines of periodontal ligament (PDL) cells (PDL(1,2,3)), cultured alone or in combination with a demineralized freeze-dried allograft (DFBA). PDL cell cultures were derived from the mid root of three maxillary caries-free premolars extracted for orthodontic reasons. Cells were grown and reached confluence. To evaluate the mitogenic effect of all exogenous factors (PRPa, PRPb, PRPc and DFBA) on PDL cells, specific number of cells (10.000/well) was cultured in the presence or absence of the above factors. Each PRP preparation (5% v/v) was added in all cell lines, in the absence or presence of 10 mg/ml of DFBA. The cells were also treated with 25 ng/ml bFGF (positive control). The mitogenic effect was evaluated 24 h after incubation, using the Trypan blue exclusion assay. The results revealed that all PRP preparations act as potent mitogens as they significantly induced cell proliferation on PDL(1,2,3) lines. All PRP preparations when added alone in the PDL cell cultures, exhibited a significant advantage over the positive control (bFGF). The addition of DFBA to PRP did not influence significantly cell proliferation in all cell lines, comparatively to PRP alone, at the time -period studied. The findings of this study demonstrate the beneficial role of PRP alone or combined with the bone graft on periodontal ligament cells in vitro, suggesting that it may be considered as a potential biological approach in periodontal regeneration.

show abstract

“…Acceleration of hard tissue maturation and block graft procedures also produces a quantity of immature hard osteoid tissue within lesser time than the conventional time, hence improves primary stability for implant along with 20% greater trabecular bone density and 85% greater proportion of mature haversian system in the initial months supported by no evidence of active resorption and remodeling, indicating a level of stable maturity. 8,32 The main purpose of PRP is to reduce the use of autologous bone graft collected from the patients sites and reducing the mucosal incisions 32 Though Ozdemir, Raghoebar, Schaaf et al conveyed no beneficial effects of PRP with grafts in their literature [33][34][35][36][37][38][39][40][41][42][43] (Table 2).…”

Section: Marx Et Al Supported By Garg Et Al 2004mentioning

confidence: 99%

The Clinical Application Of Platelet Concentrates: A Systematic Meta-analysis

Gada¹

2015

International Journal of Prosthodontics and Restorative Dentistry

View full text Add to dashboard Cite

Background: Autologous plasma rich in platelets is derived blood product whose uses in dentistry dates back to the 1990s and it has been gaining popularity ever since.Aim: A systematic review of the available literature to determine the efficacy, safety and success of platelet concentrates in physiological systems as well as describing its vigilant use. Study design and methods:A Medline search with keywords 'platelet rich plasma dental' further filtered using Boolean operators (AND, Or, NOt) and combination of specific keywords as follows: 'platelet rich fibrin', 'platelet rich plasma regenerative', 'platelet rich plasma periodontal', 'platelet rich plasma extraction' with a custom range of 10 years was performed, which yielded 88 results out of which 32 were selected based on the inclusion criteria.Results: Significantly, successful outcomes have been witnessed in the field of osteoregeneration though it has been evidenced that adequate platelet rich plasma (PrP) additives are essential to bear a therapeutic potential. Favoring blood cell adhesion on the root surface optimizing periodontal healing, PrP has also shown positive effect on gingival repair; though controversial facts have also been reported. In the scope of implant dentistry, PrP has also reported greater implant-bone contact when used in both gel or liquid form. Emerging as a possible pulp capping agent along with properties of decreased chances root growth, PrP has successfully completed apexogenesis in cases of pulpotomy.research has shown that although clinical results from the comparison of PrP alone vs PrP and resorbable membrane or various graft materials has shown a varied results, additional research in the field is needed. Conclusion:Platelet rich plasma has shown promising results in the field of regenerative dentistry, with high success rate in implantology, periodontology and oral surgery. Because of conflicting success rates reported in literature further research is warrented. Clinical implication:Platelet rich fibrin has displayed various features of rapid clinical healing, excellent bone density, less surgical time, less resorption during healing and decreased postoperative pain, as compared to guided bone regeneration procedures. Platelet rich plasma has also shown a myriad of applications ranging from hard tissue regeneration to soft tissue management, stretching across to the field of pediatric dentistry and endodontics.

show abstract

A Surgical Reentry Study on the Influence of Platelet‐Rich Plasma in Enhancing the Regenerative Effects of Bovine Porous Bone Mineral and Guided Tissue Regeneration in the Treatment of Intrabony Defects in Humans

Abstract: Within the limitations related to using a small sample size, PRP did not significantly augment the effects of BPBM and GTR in promoting the clinical resolution of intrabony defects.

Cited by 53 publications

References 37 publications

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

The effect of platelet-rich plasma (PRP) combined with a bone allograft on human periodontal ligament (PDL) cells

The Clinical Application Of Platelet Concentrates: A Systematic Meta-analysis

Contact Info

Product

Resources

About