A sulfated polysaccharide from<i>Gracilaria Lemaneiformis</i>regulates cholesterol and bile acid metabolism in high-fat diet mice

Huang, Shiyu; Pang, Daorui; Xiong, Li; You, Lijun; Zhao, Zhengang; Cheung, Peter C.K.; Zhang, Mingwei; Liu, Dong

doi:10.1039/c9fo00263d

Cited by 79 publications

(57 citation statements)

References 41 publications

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“…Genus Odoribacter had been reported with a negative correlation with lipid profiles especially cholesterol level. Genus Alistipes was involved in bile acid metabolism (Huang et al, 2019 ). The possible internal connection might be that the hydrolysis of glucuronidated and sulfated iodothyronines and the hydrolysis of conjungated bile acid share the similar metabolic process in the gut.…”

Section: Resultsmentioning

confidence: 99%

Relation of Gut Microbes and L-Thyroxine Through Altered Thyroxine Metabolism in Subclinical Hypothyroidism Subjects

Yao

Zhao

Gong

et al. 2020

Front. Cell. Infect. Microbiol.

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Section: Resultsmentioning

confidence: 99%

Relation of Gut Microbes and L-Thyroxine Through Altered Thyroxine Metabolism in Subclinical Hypothyroidism Subjects

Yao

Zhao

Gong

et al. 2020

Front. Cell. Infect. Microbiol.

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“…The diverse data might be due to the ingredients of HFD and the duration for HFD feeding. Lachnospiraceae NK4A136 group positively correlates to bile acids indicating it involving in cholesterol homeostasis [40]. Zhang et al have found that the abundance of Lachnospiraceae NK4A136 group increases in type 2 diabetes mellitus rat and returns to the level as the control after fed with anthraquinone-glycoside [42].…”

Section: Discussionmentioning

confidence: 98%

“…In HFD mice, Lachnospiraceae NK4A136 group is reduced and negatively correlates to triglyceride [39]. Instead, Liu et al have been reported that the abundance of Lachnospiraceae NK4A136 group has no effect at high-fat diet-fed mice; however, it elevates after fed with a sulfated polysaccharide from Gracilaria Lemaneiformis [40]. The diverse data might be due to the ingredients of HFD and the duration for HFD feeding.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, obese mice with fucosylated chondroitin sulphate feeding showed the anti-in ammation effects as well as the elevation of Lachnospiraceae NK4A136 group [41]. However, Liu et al have reported that the abundance of Lachnospiraceae NK4A136 group did not affect in high-fat diet-fed mice [40]; Zhang et al demonstrated that the increase of Lachnospiraceae NK4A136 group in type 2 diabetes mellitus rats and the bacterial level returns back to control after fed with anthraquinone-glycoside [42]. Whether the Lachnospiraceae NK4A136 group level could be modi ed by dietary fat content remains elusive.…”

Section: Introductionmentioning

confidence: 95%

“…In HFD mice, the numbers of Lachnospiraceae NK4A136 group were reduced and negatively correlated to triglyceride levels [39]. The elevation of Lachnospiraceae NK4A136 group was found in mice fed with Gracilaria Lemaneiformis-derived sulfated polysaccharide and positively correlated to the secretion of bile acids [40]. Moreover, obese mice with fucosylated chondroitin sulphate feeding showed the anti-in ammation effects as well as the elevation of Lachnospiraceae NK4A136 group [41].…”

Section: Introductionmentioning

confidence: 97%

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A potential probiotic- Lachnospiraceae NK4A136 group: Evidence from the restoration of the dietary pattern from a high-fat diet

Chou

Huang

et al. 2020

Preprint

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Background: High-fat diet (HFD) that contributes to obesity is one of the pivotal risk factors for metabolic syndrome and cancers. The dietary pattern can shape the intestinal bacterial community and influence the physiological parameters. This study aimed to investigate whether the short-term dietary pattern shift from HFD to a balanced chow diet (CD) could correct HFD-induced colonic dysbiosis and reverse adverse health effects and identify the specific bacteria that changed by dietary patterns. Results: C57BL/6 mice fed with an HFD for 10 months, followed by a CD for 3 months, served as the dietary shift model. Stool samples were collected for bacterial analysis. Physiological parameters, such as serum adipokines, blood lipid levels, and hepatic function, were monitored in control and dietary shift groups. HFD-induced weight gain was mitigated by the dietary shift. A highly similar structure at the phylum, genus, and species levels was observed in the beta diversity of colonic bacteria in mice that underwent the dietary shift as compared to those in the control group. Notably, the abundance of Peptococcaceae and Akkermansiaceae in HFD-fed mice reduced after the dietary shift; whereas the diminished amount of probiotic Lachnospiraceae NK4A136 group in HFD-fed mice was restored to the level comparable to those in controls after the dietary shift. Conclusions: Our finding suggests that a dietary switch from a long-term HFD to a short-term balanced diet has the potential to correct colonic dysbiosis and restore physiological homeostasis. The Lachnospiraceae NK4A136 group has the potential to be a probiotic.

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Macro insights into the shared and distinct regulations of dietary polysaccharides on gut microbiota and their roles in obesity

Xie,

Huang,

Cai

et al. 2023

Food Safety and Health

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Obesity has emerged as a global health epidemic, demanding a comprehensive understanding of its etiology and potential interventions. Recent studies have highlighted the crucial role of gut microbiota in maintaining host health. Additionally, dietary polysaccharides (DP), such as pectic polysaccharides, sulfated polysaccharides, glucan‐like polysaccharides, and fructan‐like polysaccharides, have been identified as crucial regulators that influence gut microbial composition, function, and metabolite production, thereby improving obesity and mitigating its complications. This review comprehensively summarizes the latest findings regarding the sources and structural characteristics of different DP, their shared and distinct effects on gut microbiota and associated metabolites, and the consequent influence on obesity and its complications. By unraveling the complex interplay among DP, gut microbiota, and obesity‐related outcomes, we strive to offer valuable insights that can inform the development of precise dietary interventions and therapeutic strategies aimed at tackling obesity and enhancing public health.

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A sulfated polysaccharide fromGracilaria Lemaneiformisregulates cholesterol and bile acid metabolism in high-fat diet mice

Abstract: This study aimed to evaluate the regulation of lipid metabolism and mechanism of a sulfated polysaccharide from Gracilaria Lemaneiformis (GLP).

Cited by 79 publications

References 41 publications

Relation of Gut Microbes and L-Thyroxine Through Altered Thyroxine Metabolism in Subclinical Hypothyroidism Subjects

Relation of Gut Microbes and L-Thyroxine Through Altered Thyroxine Metabolism in Subclinical Hypothyroidism Subjects

A potential probiotic- Lachnospiraceae NK4A136 group: Evidence from the restoration of the dietary pattern from a high-fat diet

Macro insights into the shared and distinct regulations of dietary polysaccharides on gut microbiota and their roles in obesity

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