A Successful Short-Bowel Syndrome Model in Neonatal Piglets

Abstract

In 7-day-old piglets 75% small bowel resection leads to a clinical short-bowel syndrome, demonstrated by reduced weight gain and typical changes in bowel adaptation parameters. The excellent survival of the animals provides a possibility for the study of bowel adaptation in a neonatal model as well as in intervention studies.

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

“…Experimental numbers were low, and mortality ranged from 6 to 18% where reported (52). One report of 75% SBR in 7-day-old piglets reported 8% mortality rate at 28 days; however, the animals were fed a standard amount of calories per body weight daily and were supplemented with electrolytes, additional costly and workintensive interventions (15).…”

Models of Short Bowel Syndrome in Pigs: A Technical Review

“…The majority of studies used domestic pigs or piglets [5,13,16,17,18,19] mainly of female gender [10,13,16,18,20,21,22,23,24,25,26,27,28,29]. Regarding the exact breed, mostly landrace [10,21,22,30,31] or landrace × large white [5,13,16,20,24,26,32,33,34] animals were used.…”

“…Regarding the exact breed, mostly landrace [10,21,22,30,31] or landrace × large white [5,13,16,20,24,26,32,33,34] animals were used. SBS models were seldom described in other types of pig [7,23].…”

“…In some cases, the pigs were younger than 7 days [21,29,34,37], but in most cases they were between 3 and 8 weeks [13,16,18,20,24,26,27,28,32,33]. In rare cases, older pigs (3-7 months) were chosen [5,7].…”

“…If mentioned, most often anesthesia with halothane and oxygen [17,18,21,24,27] or isoflurane [19,37] was performed, sometimes in combination with ketamine and azaperone [7]. In rare occasions, other strategies such as anesthesia with propofol, fentanyl and pancuronium [5], thiopental sodium and ketamine [7], or a combination of the mentioned drugs [29,41] were chosen.…”