A study to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications

Abstract

Background: Diabetes Mellitus is a global pandemic disease. The increased platelet activity is emphasized to play a role in the development of vascular complications of the metabolic disorder. Mean platelet volume (MPV) is an indicator of average size and activity of platelets. This study was conducted to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications.Methods: Total of 100 subjects was enrolled in the study. Sample for glucose estimation and platelet indices were collected and estimation were carried out by the auto-analyzers. The statistical evaluation is done using SPSS version 22. Student t- test was used for doing comparison between two variables namely HbA1c <7 and HbA1c ≥7 and diabetics with vascular complications v/s without vascular complications.Results: MPV, is significantly higher in patients with type -2 diabetes mellitus with HbA1C ≥7 and those with vascular complications in comparison to patients having HbA1c <7 and those without vascular complications ( p- value <0.001 which is highly significant).Conclusions: MPV might be used as a simple and cost-effective laboratory test in the follow up of diabetes mellitus along with HbA1c and thereby help to reduce the morbidity and mortality.

Utility of Platelet Indices in Assessing the Risk of Coronary Artery Disease in Patients of Diabetes Mellitus

“…In the present study, the platelet distribution width (PDW) was signi cantly higher in diabetics subjects when compared to controls, similar results was seen with the study conducted by Dindar et al [13] The difference between PDW of group A and group B was insigni cant which was similar to studies conducted by Dubey I et al and Shilpi K et al, but in discordance with other studies. [1,10,11,14] In addition, P-LCR was also found to be higher in diabetics when compared to control subjects similar to other studies. [1,12] However, in the present study the difference of P-LCR between group A and group B was insigni cant which was in accordance with other studies but in discordance with some studies.…”

“…[1,10,11,14] In addition, P-LCR was also found to be higher in diabetics when compared to control subjects similar to other studies. [1,12] However, in the present study the difference of P-LCR between group A and group B was insigni cant which was in accordance with other studies but in discordance with some studies. [2, 8-10, 12, 15] The discordance which was seen in our study may be due to the fact that the patients with coronary complications (group B) were on antiplatelet therapy.…”

“…Diabetes mellitus (DM) is a pandemic disease and most challenging problem in today's world. [1] It is considered as a "prothrombotic state" owing to sustained hyperglycemia, dyslipidemia and insulin resistance causing endothelial and pericyte injury. Altered platelet morphology have been observed in diabetes in the form of enhanced platelet activity.…”

A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes

“…In addition to that, platelet count is a significant clinical variable used in markers of liver fibrosis such as the fibrosis 4 (FIB4) index [17] in the field of diabetes care, because patients with T2DM had been known to have a high prevalence of fatty liver disease, which spans a wide spectrum from simple steatosis to cirrhosis [18]. Therefore, the use of platelet indices, including platelet count, has recently attracted attention for patients with T2DM [19,20].…”

Cross-sectional correlates of myeloperoxidase and alpha-1-acid glycoprotein with adiposity, atherogenic and hematological indices in metabolic syndrome patients with or without diabetes

“…15 Hematological indices such as mean platelet volume (MPV), platelet count (PLT count) and white blood cell subtypes are among the inflammatory markers considered reliable prognostic indicators for diabetes complications. 16,17 Coronary artery disease risk is significantly associated with higher and lower triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), respectively, 18 alongside the atherogenic index of plasma (AIP), log TG/HDL-C), which is a surrogate estimate of the atherogenic dyslipidemia among T2DM patients. 19 The risk of coronary heart diseases in diabetic patients could be greatly estimated using adiposity markers such as the conicity index (C-index), body adiposity index (BAI) and waist-height ratio (WHtR).…”