A study on the role of FMR1 CGG trinucleotide repeats in Jordanian poor ovarian responders

Can FMR1 CGG repeat lengths predict the outcome in ICSI cycles?

“…However, the authors also reported that they did not find a significant relationship between CGG repeats and ovarian reserve markers, similar to our study. The authors concluded that although low CGG repeats appeared to be associated with POR as a result of their study, the clinical use of FMR1 to predict ovarian response needs further research [34].…”

“…In another study conducted by Fıçıcıoğlu et al [33], they suggested that the triple repeat numbers of CGG can predict a reduced ovarian reserve before the onset of ovarian aging, and that in clinical practice CGG repeats can be used to predict premature ovarian aging (FSH > 12-50IU/mL) and ovarian reserve. A recent study by Batiha et al [34], evaluated the relationship between short CGG repeats (< 26; 26-34; > 34) and poor ovarian response. The researchers reported that CGG median allele sizes differed significantly between cases and controls, and poor ovarian responders carried shorter CGG repeats compared to healthy controls.…”

Genetic determination of the ovarian reserve: a literature review

“…The Fragile X Mental Retardation 1 ( FMR1 ) gene is commonly associated with neuropsychiatric disorders, but it has been shown to play a role in other pathologies as well. Apart from classical FMR1 disorder symptoms (tremor and ataxia), ovarian dysfunction is also common [ 12 ]. FMR1 mutations provoke different pathological changes along with the decline of the ovarian reserve.…”

“…Approximately 20% of women with permutation have FXPOI and significant decline of ovarian reserve [ 12 ]. Studies show that the rate of permutation is 1:150–300 in the female population but it this constant varies significantly dependent on ethnicity, race, environmental and other factors [ 16 , 17 ].…”