A Study on the Nucleolar Organizer Regions-As a Tumour Proliferative Marker in Cervical Smears

Abstract

Aim: To study the Argyrophilic Nucleolar Organizer Regions (AgNOR) as a cell proliferative marker in cervical smears and to assess its counts with the severity of the lesions on Papanicolaou (PAP) stained cervical smears. Material and Method:The present study was a prospective experimental study which was carried out at Jawaharlal Nehru Medical College in a span of 2 years. 50 high risk cases were selected from the Gynaecological OPD. The cervical smears were collected in pairs, one for the conventional PAP staining and the other one for the specialized AgNOR staining.Statistical Analysis: The Student's unpaired 't' test was used.

Well Differentiated Villoglandular Papillary Adenocarcinoma of the Cervix: A Rare Case Report

“…concluded that stage is the most important prognostic factor with 5-year overall survival rates varying on stage: FIGO stage I -79%, II -37%, III / IV -less than 9% [9]. Studies reflecting on different types of cervical cancer [10][11][12], ovarian tumours [13][14][15][16] were reviewed.…”

Silver Stained Nucleolar Organising Region (AgNOR) Count and its Correlation with Colposcopy in Suspicious Cervical Pathology

“…Mean AgNOR count: In this study, the mean AgNOR count increases as disease progresses from chronic cervicitis to CIN I to CIN II to CIN III to squamous cell carcinoma. Samarth [8] et al (2012) conducted a study on 50high risk women. They took 2 cervical smears.…”