A study on the glycaemic balance in streptozotocin-diabetic rats treated with an aqueous extract ofFicus carica (fig tree) leaves

Pérez, Carmen; Domı́nguez, Elisa; Ramiro, J. M.; Romero, Adelaida; Campillo, J. E.; Torres, M.D.

doi:10.1002/(sici)1099-1573(199602)10:1<82::aid-ptr776>3.0.co;2-r

Cited by 54 publications

(27 citation statements)

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“…In the present study, administration of ethanolic extract of CT to diabetic rats (Groups III) increased bodyweight significantly, which was comparable to experiments of Chakrobarty and Das. [15] Results of the present study are supported partially by the findings of Perez et al .,[16] who also observed significant ( P < 0.05) increase in body weight after treatment with extract of Ficus carica (fig tree) leaves in streptozotocin-diabetic rats, which may be due to the lipid lowering activity of the extract or indirectly due to the influence on various lipid regulation systems.…”

Section: Discussionsupporting

confidence: 88%

Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Bisht¹,

Sisodia²

2011

Indian J Pharmacol

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Objective:To establish the effect of Cinnamomum tamala leaves extract on diabetes and diabetes induced dyslipidemia in streptozotocin-induced diabetic rats.Materials and Methods:Diabetes was induced by a single intravenous injection of streptozotocin (50 mg/kg body weight). Group I and II were kept as control and diabetic control respectively. And group III was further treated with ethanolic leaf extract of C. tamala (200 mg/kg body weight, orally) for a period of 40 days. Oral glucose tolerance test was performed before starting the experiment and blood glucose level was estimated. Statistical analysis was performed using one-way Analysis of Variance (using Statistical Package for the Social Sciences [SPSS] version 10.0) and student's ‘t’- test (Sigma Plot version 8.0). The values of P < 0.05 were considered as statistically significant.Results:Treatment of diabetic animals with Cinnamomum tamala extract significantly lowered the blood glucose level, and maintained body weight and lipid-profile parameters towards near normal range.Conclusion:The extract exhibited antidiabetic and antidyslipidemic effect. Further, chemical and pharmacological investigations are required to elucidate the exact mechanism of action of this extract and to isolate the active principles responsible for these effects.

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Section: Discussionsupporting

confidence: 88%

Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Bisht¹,

Sisodia²

2011

Indian J Pharmacol

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“…Another study was performed to evaluate the hypoglycemic effect of an aqueous extract of leaves. Findings of the study showed that extract has a clear hypoglycemic activity in treated versus non-treated diabetic rats [36].…”

Section: Antidiabetic Activitysupporting

confidence: 60%

Ficus Carica and Its Constituents Role in Management of Diseases

Rahmani

Aldebasi

2017

Asian J Pharm Clin Res

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Alternative medicines or formulation based on natural sources are good option in diseases cure and prevention. Ficus carica is member of Moraceae family and its health management properties have been mentioned in religious books and traditional medicines. It holds various constituents including phenolic compounds, minerals and vitamins and such ingredient shows role in disease cure. Studies based on in vivo and in vitro reported that figs fruits, stem, leaves, and latex have health management effect through antioxidant, anti-inflammatory effects, antimicrobial, anticarcinogenic, and anti-inflammatory effects. Moreover, an inverse correlation between figs use and development of disease has been noticed. Despite its implications in disease management, little is known about their mechanism of action. In this review, efforts are made based on in vivo and in vitro studies to illuminate the role of F. carica leaves and fruits in the prevention of diseases.

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“…TLC analysis of hydrophilic extract indicated the presence of flavonoid as in the case of Ficus bengalensis (Geetha et al, 1994). However, the blood glucose lowering efficacy of methanol extract was only comparable to F. carica and F. racemosa (Pérez et al, 1996;Rao et al, 2002) and this suggested that such extract was suitable for use as adjunct instead of mainstream therapeutic substance.…”

Section: Discussionmentioning

confidence: 91%

“…Commercially, F. deltoidea has been formulated and distributed as a tea, tonic drink, and in capsule by various companies such as Raza Bio Marketing Sdn Bhd, DBPS Holdings Sdn Bhd, Polens (M) Sdn Bhd, Sri Ain D Herbs, Bioworld Resources Sdn Bhd, Shn Niaga Enterprise, Kristal Berlian Enterprise and Delto Medicama Plantation. Previous blood glucose lowering efficacy tests of Ficus racemosa Linn, Ficus carica Linn and Ficus bengalensis Linn reported that the extracts or constituents of Ficus species could reduce the blood glucose level of rats but their efficacy was not entirely satisfactory (Geetha et al, 1994;Pérez et al, 1996;Rao et al, 2002). The F. carica extract only exhibited a reduction extent of blood glucose level by 20% and leucodelphinidin derivative of F. bengalensis was not as effective as sulphonylurea.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents

Yaacob

Wong²,

Choo³

2011

Journal of Complementary and Integrative Medicine

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Ficus deltoidea Jack (Moraceae) leaf extract is used as an antidiabetic in traditional medicine. Its widespread usage is reflected by the available preparations in the present commercial market. The efficacy of other Ficus species has not been entirely satisfactory and many antidiabetic herbs have demonstrated poor safety profiles. This study examined hypoglycemic and toxicity profiles of F. deltoidea leaf extract in rodent models. Extracts of dried powdered leaves were obtained using methanol solution, n-hexane, chloroform, and n-butanol. These extracts were orally administered to rodents. Their blood glucose and insulin levels, acute and subchronic toxicity, biochemical and histological profiles of liver and kidney were determined. Methanol extract exhibited blood glucose lowering activity in mildly insulin resistant diabetic rats as well as in normoglycemic mice unlike hydrophilic butanol subextract which only expressed its activity in normoglycemic mice. Methanol extract could contain both insulin receptor sensitization and secretagogue constituents. Different from toxic chloroform and hexane subextracts, hydrophilic methanol extract gave zero percent mortality up to 6400 mg/kg in 14 days. It did not induce liver and kidney toxicity upon four-week consumption at 200 mg/kg. The methanol extract possessed mixed antidiabetic actions and exhibited a low level of oral toxicity.

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A study on the glycaemic balance in streptozotocin-diabetic rats treated with an aqueous extract ofFicus carica (fig tree) leaves

Cited by 54 publications

References 0 publications

Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Ficus Carica and Its Constituents Role in Management of Diseases

Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents

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