A study on the efficacy of topical 10% potassium hydroxide in the treatment of <i>Molluscum contagiosum</i>

Sequeira, Flavia; Bala, Nanda Kishore; Hundi, Ganesh Kamath; Martis, Jacintha

doi:10.4103/0975-9727.174604

Cited by 3 publications

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“…10 Similarly, a study done by Sequeira et al also found 10% potassium hydroxide solution to be an effective and safe treatment modality for the pediatric patients with molluscum contagiosum. 11 The present study showed no statistically significant difference in the side effects in both the groups after stratification of patients according to number of lesions. This finding is also supported by the study results of Kose et al 5 and Can et al 10 Contrary to this, a study showed side effects of mild pain in 55% of patients, mild burning sensation in 20% of patients and secondary bacterial infection in 10% of patients, but in this study topical potassium hydroxide was used in a higher concentration of 20% instead of 10%.…”

Section: Discussioncontrasting

confidence: 60%

Comparison of Safety and Efficacy of Potassium Hydroxide versus Combination of Salicylic and Lactic Acid for Molluscum Contagiosum

Pirzada¹,

Abdullah²,

Zia³

et al. 2019

JIMDC

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Background: Molluscum contagiosum (MC) is a contagious cutaneous infection caused by MC virus, affecting mainly the pediatric population. It is characterized by flesh-colored umbilicated papules occurring on the skin surface. Potassium hydroxide (KOH) and salicylic acid plus lactic acid combination being keratolytic agents, are effective treatment options. The objective of the study was to compare the efficacy and safety of 10% KOH solution versus salicylic acid/ lactic acid combination in treating Molluscum contagiosum in pediatric population. Material and Methods: A total of 80 children (age range 1-13 years) with Molluscum contagiosum lesions were selected from the Dermatology Out-Patient Department, and were randomly allocated into two groups by lottery method. Group A was given topical 10% KOH solution and group B was given Salicylic plus Lactic acid preparations for topical application. Patients were followed after two weeks to see regression in size of the lesion, and development of any side-effects. Final visit was scheduled at 6 weeks. Statistical analysis was carried out using SPSS (version 16) with p value less than 0.05 considered as statistically significant. Results: Patients with MC (n = 80) were equally divided into group A (treated with 10% KOH) and group B (treated with combination of Salicylic acid and Lactic acid). After 6 weeks, complete remission from Molluscum contagiosum virus was seen in 29 (72.5%) patients of group A and 34 (85%) patients of group B. There were 12 (30%) patients in group A who developed local irritation and 4 (10%) developed local erythema after 6 weeks. None of the patients of group B had any such side effects. Conclusion: 10% KOH solution is as effective as the combination of Salicylic and Lactic acids for treatment of Molluscum contagiosum in pediatric population, however it is associated with side effects of local irritation and erythema.

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Section: Discussioncontrasting

confidence: 60%

Comparison of Safety and Efficacy of Potassium Hydroxide versus Combination of Salicylic and Lactic Acid for Molluscum Contagiosum

Pirzada¹,

Abdullah²,

Zia³

et al. 2019

JIMDC

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“…Existing treatment options are associated with substantial pain, tissue destruction, and frequent recurrences, however these are not tolerated well by patients due to pain and fear. Since the disease is self-limiting and generally resolves spontaneously, treatment should not be excessive or overly aggressive [7,8].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Apple Cider Vinegar in the treatment of Molluscum Contagiosum: a Randomized Placebo- Controlled Trial

Sacil,

Morales,

Torres

2024

J Dermatol Res Rev Rep

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Introduction: Molluscum Contagiosum is a common pox viridae infection among children. Although the condition is benign and self-limiting, treatment is warranted to prevent spread through auto-inoculation or close physical contact. To date no single treatment modality has been proven effective. Apple Cider Vinegar may be an alternative therapeutic option which can be used at home that is non-painful and effective. Objectives: To determine the efficacy and safety of Apple Cider Vinegar in the treatment of Molluscum Contagiosum Methods: The study is a randomized controlled clinical trial that was conducted at the Department of Dermatology of Ospital ng Maynila Medical Center using two types of topical treatment. Fourteen patients aged 2 to 18 who were clinically diagnosed with Molluscum Contagiosum were randomly allocated using sealed paper to apply Apple Cider Vinegar (n=8) or placebo (n=6) on the lesions twice daily for 6 weeks. The patients were blinded to the treatment allocation. Clinical parameters of resolution where noted at weeks 2, 4 and 6. Results: Demographic characteristics showed no statistical difference (p > 0.05). The comparison of apple cider vinegar with the control group did not give any significant difference in resolution of lesions between the two groups at any time point. Erythema was noted by the experimental group which was statistically significant (p = 0.04) Discussion: Apple cider showed promising results when half of the patients in the group showed inflammatory changes, with some of the lesions disappearing by the 4th and 6th week of administration. However, there was no statistical difference in the resolution of the lesions when compared to the placebo group.

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The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis

Heo

Park

Kim

2021

Journal of Dermatological Treatment

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A study on the efficacy of topical 10% potassium hydroxide in the treatment of Molluscum contagiosum

Cited by 3 publications

References 0 publications

Comparison of Safety and Efficacy of Potassium Hydroxide versus Combination of Salicylic and Lactic Acid for Molluscum Contagiosum

Comparison of Safety and Efficacy of Potassium Hydroxide versus Combination of Salicylic and Lactic Acid for Molluscum Contagiosum

Efficacy and Safety of Apple Cider Vinegar in the treatment of Molluscum Contagiosum: a Randomized Placebo- Controlled Trial

The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis

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