A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aβ 1-42 Biomarker

Dulla, Blessina Sugandhi; Bindhu, S; Pramod, K. Leena

doi:10.1055/s-0041-1736274

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…). AlCl 3 (100mg/kg for 42 days) showed an increase in the transfer latency showing impairment in memory retention (Dulla and Bindhu 2021). Further, no signi cant difference was observed in the transfer latency of day-1 and day-2.…”

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confidence: 85%

Induction of Type 3 Diabetes mellitus by the Administration of Smaller Doses of Aluminium Chloride to the STZ Pretreated Rats

Ahlawat

Walia

Garg

2022

Preprint

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The present study is designed to develop Type-3 diabetes mellitus characterized by insulin resistance, mainly at the brain level. The experimental rats in group-1: received vehicle (5 ml/kg, i.p.) for 28 days, group-2-4: received aluminium chloride (AlCl3) (12.5, 25, and 50 mg/kg, i.p.) daily for 28 days, group-5: received single dose of STZ (45 mg/kg, i.p.), and group-6-8: received STZ and AlCl3 (12.5, 25, and 50 mg/kg, i.p. daily for 28 days) from the third day of STZ administration. The behavioral analysis was initiated on the 29th day, estimating locomotor activity using an open field test, learning and memory-related functions using elevated plus maze (EPM) and morris water maze (MWM) tests. Afterwards, the rats were sacrificed, and brain and blood were collected for whole-brain neurochemical and plasma biochemical assays, including glucose, insulin, nitrite, MDA and amyloid-beta levels. The brain tissues were sectioned, followed by H&E and congo red staining for histopathological examination. The results obtained demonstrated that the STZ pretreatment and AlCl3 (12.5 mg/kg) treatment significantly impaired the cognition in EPM and MWM. Also, the STZ pretreatment and AlCl3 (12.5 mg/kg) treatment significantly increased the brain glucose levels, brain insulin levels, lipid peroxidation and amyloid levels, suggesting the development of hyperinsulinemia, insulin resistance and amyloid pathology. Further, STZ pretreatment and AlCl3 (12.5 mg/kg) treated rats produced the marked degenerated neurons, neuronal loss, and the marked deposition of amyloid fibrils suggesting the development of neurodegenerative changes. In conclusion, the present findings suggested that administering low doses of AlCl3 to the STZ pretreated experimental rats results in the development of marked hyperinsulinemia, insulin resistance, cognitive impairment, amyloid-beta deposition, and neuronal degeneration, reflects the features of Type-3 diabetes mellitus (T3DM).

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confidence: 85%

Induction of Type 3 Diabetes mellitus by the Administration of Smaller Doses of Aluminium Chloride to the STZ Pretreated Rats

Ahlawat

Walia

Garg

2022

Preprint

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Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model

Chen,

Li,

Wang

et al. 2024

Journal of Drug Targeting

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Ethnopharmacology properties of Medicinal plants used by the community in Gunung Halimun Salak National Park, West Java, Indonesia

Quarta Lailaty,

Peniwidiyanti,

Ismaini

et al. 2024

RJPT

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The community in Gunung Halimun Salak National Park (GHSNP) uses several plants as alternative medicine in their daily life. Those medicinal plants were sorted from the highest to the lowest value based on Index Cultural Significance (ICS). Thirteen selected native plants from GHSNP were investigated for their antimicrobial and antioxidative potential using DPPH scavenging. Their phytochemical compositions were profiled by phytochemical screening and GC-MS analysis. Staurogyne elongata (ICS= 351) and Blumea balsamifera (ICS= 228) were the most widely used plants in the five hamlets in Cikaniki Resort. Phytochemical screening produced a different color reaction (alkaloids, flavonoids, tannins, and terpenoids) and the presence of foam (saponins) for several species. Plantago major had the highest total phenol and flavonoid content, not significantly different from Turpinia montana. Aquadest extract from Heptapleurum fastigiatum had the highest antioxidant activity (IC50 14.24mg/L). The study showed the highest inhibitory activity for T. montana against Staphylococcus aureus. Meanwhile, the ethanolic extract of S. elongata and Lophatherum gracile inhibited both S. aureus and Escherichia coli's growth. The GC-MS analysis of the ethanolic extracts showed a wide chemical diversity, including 79 compounds from five species, distributed by fatty acids, sesquiterpenes, diterpenes, alkanes, and other organic compounds. Interestingly, GC-MS analysis enabled to identify of several compounds with antioxidant and antibacterial activity in their extracts, such as (-)-Globulol, alpha-cadinol, spathulenol, longifolene, octadecamethyl-cyclononasiloxane, gamma-muurolene, tetracosamethyl-cyclododecasiloxane, and trans-calamenene. The thirteen native species of GHSNP have potential health properties to be utilized and developed as traditional medicine.

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A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aβ 1-42 Biomarker

Cited by 3 publications

References 28 publications

Induction of Type 3 Diabetes mellitus by the Administration of Smaller Doses of Aluminium Chloride to the STZ Pretreated Rats

Induction of Type 3 Diabetes mellitus by the Administration of Smaller Doses of Aluminium Chloride to the STZ Pretreated Rats

Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model

Ethnopharmacology properties of Medicinal plants used by the community in Gunung Halimun Salak National Park, West Java, Indonesia

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