A study on the clinical profile of complicated Plasmodium vivax mono–infections

George, Peter; Alexander, Lobo Manuel

doi:10.1016/s1995-7645(10)60135-6

Cited by 20 publications

(19 citation statements)

References 18 publications

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“…vivax malaria. (19,20) Studies from Qatar and Venezuela had shown the similar results. (21,22) There is no matched control group.…”

Section: Discussionsupporting

confidence: 53%

Correlation of Type of Species and Parasite Density in Malaria With Platelet Count, Mean Platelet Volume and Platelet Distribution Width

Kumar¹

2016

jemds

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BACKGROUNDMalaria is an important infectious protozoan disease and it has been estimated that worldwide there are 300 -500 million cases of malaria per year and 1.5 -2.7 million deaths. The early diagnosis of malaria is the key feature for its prompt treatment and prevention of complications. The study was conducted to statistically analyse other haematological parameters like platelet indices that is Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) along with platelet count. Correlation of the above was done with parasite density and type of species. An attempt was made to study whether platelet indices and counts are indicative of type of infection.

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“…vivax malaria. (19,20) Studies from Qatar and Venezuela had shown the similar results. (21,22) There is no matched control group.…”

Section: Discussionsupporting

confidence: 53%

Correlation of Type of Species and Parasite Density in Malaria With Platelet Count, Mean Platelet Volume and Platelet Distribution Width

Kumar¹

2016

jemds

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“…falciparum 100 68 Murthy et al [19] 10-80 years P. falciparum 158 40.5 Mohapatra et al [20] 15-60 years P. vivax 110 3.6 Jadhav et al [8] All ages P. vivax 973 65 Kumar et al [21] All ages P. vivax 27 88.8 Prasad et al [22] <5 years P. falciparum 40 85 Kochar et al [23] All ages P. vivax/P. falciparum 1064 24.6 George et al [24] 18-66 years P. vivax 30 93.3 Srivastava et al [25] All ages P. vivax 50 82 The mechanism of thrombocytopenia in malaria is not clearly known. Immune-mediated lysis, sequestration in the spleen and a dyspoietic process in the marrow with diminished platelet production have all been postulated.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia in malaria and its correlation with different types of malaria

Gill

Makkar

Bhat

et al. 2013

Ann Trop Med Public Health

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Aim of the Study: Malaria is a major health problem in the tropics with increased morbidity and mortality. Thrombocytopenia is a common finding in malaria. Although a reliable diagnostic marker, prognostic implications could vary in the two types of malaria. This study was undertaken to assess the presence and severity of thrombocytopenia in malaria patients. Design: A total of 120 patients were included in the study and identified positive for malaria parasites on peripheral smear examination with conventional microscopy. Platelet count was done on a fully automated, quantitative, hematology analyzer. Results: Thrombocytopenia was noted in 63.33% cases. The mean platelet count in Plasmodium vivax (Pv) malaria was 1,27,652/μl (SD 78,269) with a range of 8000-3,50,000/μl, as against Plasmodium falciparum (Pf) malaria where the mean platelet count was 78,500/μl (SD 51,485) with a range of 9000-1,90,000/μl. Platelet count < 50,000/μl was noted in only 17.4% cases of Pv malaria as against 33.3% cases of Pf malaria. Conclusion: Although absence of thrombocytopenia is uncommon in malaria, its presence is not a distinguishing feature between the two types of malaria. Our study stresses the importance of thrombocytopenia as an indicator of acute malaria.

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“…Usually, the presence of such complications with Pv infection is attributed to mixed infection by both Pf and Pv parasites, with Pf being unrecognized [6]. The retrospective data analysis of malaria cases in Udupi and Dakshina Kannada coastal districts of Karnataka was done by many authors, who presented an association of Pv infection with acute respiratory distress syndrome [7][8][9][10][11]. These retrospective studies do not include Plasmodium species identification by polymerase chain reaction (PCR) methods.…”

Section: Introductionmentioning

confidence: 99%

Plasmodium vivax infection causes acute respiratory distress syndrome: a case report

Gupta

Afsal

Shetty

et al. 2015

J Infect Dev Ctries

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Plasmodium falciparum (Pf) is associated with numerous complications and high mortality, whereas Plasmodium vivax (Pv) infection is generally considered to be benign. However, severe complications, such as acute respiratory distress syndrome (ARDS) in Pv infection, are emerging. This case report highlights the complication of ARDS during the course of Pv infection in a 60-year-old woman. The diagnosis of the patient was made using microscopy, immunochromatography, and polymerase chain reaction assays for Pf and Pv species. The data indicated the presence of mono-Pv infection in the patient's blood, and Pf infection was specifically ruled out. The patient was discharged after intensive supportive care and antimalarial treatment. Pv infection is associated with ARDS and other complications such as sepsis and multi-organ dysfunction syndrome; this enhanced severity of Pv infection, if unrecognized, can lead to more deaths in malaria-endemic areas.

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A study on the clinical profile of complicated Plasmodium vivax mono–infections

Cited by 20 publications

References 18 publications

Correlation of Type of Species and Parasite Density in Malaria With Platelet Count, Mean Platelet Volume and Platelet Distribution Width

Correlation of Type of Species and Parasite Density in Malaria With Platelet Count, Mean Platelet Volume and Platelet Distribution Width

Thrombocytopenia in malaria and its correlation with different types of malaria

Plasmodium vivax infection causes acute respiratory distress syndrome: a case report

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