Thrombocytopenia in malaria and its correlation with different types of malaria

Gill, Manmeet Kaur; Makkar, Manisha; Bhat, Sachan; Kaur, Tanveer; Jain, Kishor S.; Dhir, G G

doi:10.4103/1755-6783.116521

Cited by 23 publications

(20 citation statements)

References 14 publications

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“…The miRNA-142-3p stringently controls specific cytoskeletal rearrangements required for maturation and function of megakaryocytes, and genetic deletion of miR-142-3p results in impaired megakaryocyte ablation, cytoskeletal dys-integrity, abnormal proplatelet formation and thrombocytopenia (Chapnik et al, 2014). In accordance, thrombocytopenia also occurs in experimental malaria including P. chabaudi malaria (Watier et al, 1992; Piguet et al, 2000, 2002; Gramaglia et al, 2005) and even represents a severe complication in human malaria caused by P. vivax and P. falciparum (Ansari et al, 2009; Lacerda et al, 2011; Gill et al, 2013; Gupta et al, 2013). Thus, our data showing up-regulation of mir-142-3p may suggest that protective vaccination affects hepatic megakaryopoiesis induced by P. chabaudi blood-stage malaria during crisis.…”

Section: Discussionmentioning

confidence: 87%

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

et al. 2017

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MicroRNAs are increasingly recognized as epigenetic regulators for outcome of diverse infectious diseases and vaccination efficacy, but little information referring to this exists for malaria. This study investigates possible effects of both protective vaccination and P. chabaudi malaria on the miRNome of the liver as an effector against blood-stage malaria using miRNA microarrays and quantitative PCR. Plasmodium chabaudi blood-stage malaria takes a lethal outcome in female Balb/c mice, but a self-healing course after immunization with a non-infectious blood-stage vaccine. The liver robustly expresses 71 miRNA species at varying levels, among which 65 miRNA species respond to malaria evidenced as steadily increasing or decreasing expressions reaching highest or lowest levels toward the end of the crisis phase on day 11 p.i. in lethal malaria. Protective vaccination does not affect constitutive miRNA expression, but leads to significant (p < 0.05) changes in the expression of 41 miRNA species, however evidenced only during crisis. In vaccination-induced self-healing infections, 18 miRNA-species are up- and 14 miRNA-species are down-regulated by more than 50% during crisis in relation to non-vaccinated mice. Vaccination-induced self-healing and survival of otherwise lethal infections of P. chabaudi activate epigenetic miRNA-regulated remodeling processes in the liver manifesting themselves during crisis. Especially, liver regeneration is accelerated as suggested by upregulation of let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, let-7f-5p, let-7g-5p, let-7i-5p, miR-26a, miR-122-5p, miR30a, miR27a, and mir-29a, whereas the up-regulated expression of miR-142-3p by more than 100% is compatible with the view of enhanced hepatic erythropoiesis, possibly at expense of megakaryopoiesis, during crisis of P. chabaudi blood-stage malaria.

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Section: Discussionmentioning

confidence: 87%

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

et al. 2017

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“…Study done by Gill MK et al observed 82% of patients had thrombocytopenia which is comparable to our study. 14 Another study done by Kochar DK et al showed only 31% patients had thrombocytopenia, this difference is because they had included both inpatients as well as outpatients suffering from malaria. 15 One other study on outpatients only by Goyal et al, showed 77% patients had thrombocytopenia.…”

Section: 11mentioning

confidence: 99%

To study hematological profile in malaria patients

Yadav

Kumar

2017

Int J Adv Med

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Background: Malaria has been a problem in India for centuries and it is responsible for many deaths in rural areas. This study was done to observe hematological profile in malaria patients and to study the incidence of complications in different species of malaria patients and to find any relation with hematological changes.Methods: The study was conducted at MLN Medical College, Allahabad in the Department of Medicine between January 2016 to December 2016. One hundred consecutive patients aged 18 years or more with malaria fever were interviewed and examined.Results: Out of 100 patients 26 patients had Plasmodium vivax malaria and 59 patients had Plasmodium falciparum infection while 15 patients had mixed PV and PF infection. In present study thrombocytopenia was most common hematological abnormality. Thrombocytopenia was present in 87 patients, out of them 18 had very severe thrombocytopenia while 69 had mild to moderate thrombocytopenia. Frank bleeding was present in 14 of total studied population and had both PV and PF infection. Petechial rashes were present in 10 patients. Anemia was present in 80 patients.Conclusions: Thrombocytopenia is very frequent finding in patients suffering from malaria, and even in presence of thrombocytopenia bleeding manifestations are uncommon. So, platelet transfusion should not be performed routinely in all thrombocytopenia patients, rather it should be indicated only if bleeding manifestations are present. Anemia, pancytopenia and leucopenia are other frequent laboratory findings of malaria infection.

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“…When our study is compared with Gill MK et al, 24 the baseline in the initial part is reported to be in the range of 8,000-1,30,000 platelets. This may be due to the fact that in our study we have considered the patients after three samples and the patients considered in our study belong to the paediatric age group, whereas in their study, it is also the adults who were considered.…”

Section: Discussionmentioning

confidence: 51%

A Study of Papaya Extract in the Treatment of Low Platelet Count in Malaria and Dengue Children Below 18 Years

R¹

2017

jebmh

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BACKGROUNDThe normal blood platelet count is 1,50,000-4,50,000/μL. Thrombocytopenia results from decreased production, increased destruction and/or sequestration. Although, the bleeding risk varies somewhat by the reason for the thrombocytopenia, bleeding rarely occurs in isolated thrombocytopenia at counts <50,000/μL and usually not until <10,000-20,000/μL. Coexisting coagulopathies as is seen in liver failure or disseminated coagulation, infection, platelet-inhibitory drugs and underlying medical conditions can all increase the risk of bleeding in the thrombocytopenic patient. Most procedures can be performed in patients with a platelet count of 50,000/μL. The level needed for major procedures will depend on the type of surgery and the patient's underlying medical state, although a count of approximately 80,000/μL is likely sufficient. Thrombocytopenia results from one or more of three processes-(1) Decreased bone marrow production; (2) Sequestration, usually in an enlarged spleen; and/or (3) Increased platelet destruction. In our country, malaria and dengue is quiet prevalent and is known to cause the majority of morbidity and mortality, which is a direct result of thrombocytopenia. This study is done in order to check the efficacy of a papaya extract in these two diseases and thus in turn help save thousands of life, which are in the risk zone. Majority of the study on this topic was previously done in the adults, but none of the study came close to put an effort to what happens in the children or rather the paediatric group, which in our study is considered and studied. In the previous efforts, a plethora of diseases were considered, but in our study, it has been narrowed down to two diseases, which are rampant in this part of the world. MATERIALS AND METHODSThis study was done in the Department of Paediatrics, Travancore Medical College at Kollam. The study was done in the patients who belonged to the paediatric age groups (range 9 to 18 years). The study consisted of children (30 in number) who were admitted in the hospital and confirmed to have thrombocytopenia, which was secondary to confirmed dengue or malaria. Patients were promptly examined after taking a detailed history session. The blood samples was sent to the lab. The disease was once again confirmed and thrombocytopenia was considered when three consecutive platelet count was taken and when the count was lessened by at least 10,000 platelets. The study was conducted from October 2014 to September 2015. RESULTSAfter treatment, only dengue patients responded significantly on the first day, although on the fifth day, it lacked the same pace of prognosis. After five days of treatment in both diseases, they responded very well and crossed the one and half lakhs mark. CONCLUSIONThis study effectively proves the efficacy of the papaya extract in the subsidiary treatment of the two rampant diseases. The study also suggests that the use of papaya extract has to be initiated at a very early stage as there is a significant association of the rise in the pl...

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Thrombocytopenia in malaria and its correlation with different types of malaria

Cited by 23 publications

References 14 publications

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

To study hematological profile in malaria patients

A Study of Papaya Extract in the Treatment of Low Platelet Count in Malaria and Dengue Children Below 18 Years

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