Correlation of Type of Species and Parasite Density in Malaria With Platelet Count, Mean Platelet Volume and Platelet Distribution Width

Kumar, Nidhish

doi:10.14260/jemds/2016/1498

Cited by 3 publications

(4 citation statements)

References 12 publications

(18 reference statements)

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“…Malaria parasitemia also had a moderately negative correlation with platelet count (r = −0.419, p < 0.001) ( Table 5 ). Many previous studies reported similar correlational statistics between platelet count and malaria parasitemia, 29 , 43 , 44 but this finding was in contrast to the study conducted in Brazil. 26 The decrement of platelets may be due to the role of von Willebrand factor (VWF) multimers in promoting platelet-mediated IE (infected erythrocyte) cytoadherence, and it was proposed that this mechanism may be particularly important during the first stages of malaria infection.…”

Section: Discussioncontrasting

confidence: 78%

“…In the present study, there was a moderately weak inverse correlation between platelet count and MPV (r = −0.257; p = 0.007) which was in accordance with other studies. 43 , 47 , 48 When platelets decrease in number, an early release of platelets from the bone marrow occurs. These early released platelets are larger in size, and the stimulation of megakaryocytes within the marrow by thrombopoietin in response to low platelets produces larger platelets as their nucleus becomes hyper-lobulated with the next polymer.…”

Section: Discussionmentioning

confidence: 99%

“… 27 The MPV had a weak positive correlation with PDW (r = 0.275; p = 0.008) and PCT (r = 0.235; p = 0.023) which was in accordance with the study conducted in Mangalore. 43 Mean platelet volume reflects platelet size, whereas PDW reflects variability in platelet size and is taken into account as a marker of platelet function and activation. So, a high PDW means platelet size varies greatly, which is a clue that there’s platelet activation and has been related to vascular diseases.…”

Section: Discussionmentioning

confidence: 99%

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Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Asmerom

Gemechu

Bete

et al. 2023

JBM

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Background Malaria is a major public health problem with the highest morbidity and mortality in developing countries. Hematological changes play a great role in malaria pathogenesis through platelets and platelet parameters. However, the changes in platelet parameters are not clearly described in Ethiopia. Therefore, this study aimed to compare platelet parameters and their correlation with parasitemia among malaria-infected adult patients and healthy adults. Methods An institutional-based comparative cross-sectional study was conducted involving 186 (93 malaria-infected patients and 93 healthy adults) study participants using a convenient sampling technique at Jinella health center, Harar, Eastern Ethiopia, from July 10–August 10, 2022. Five milliliters of venous blood were collected from each study participant, and platelet parameters were analyzed using a Unicel (DxH 800) automated hematologic analyzer. A drop of blood was taken from malaria-suspected patients for blood film preparation. Results between two groups were compared using the Mann–Whitney U -test. Spearman’s rank correlation coefficient was used to evaluate the relationships between two continuous variables. A P-value of < 0.05 was considered statistically significant. Results Platelet, plateletcrit, and mean platelet volume of malaria-infected patients were significantly lower as compared with healthy adults (103 x10 3 cells/μL vs 268 x10 3 cells/μL, 0.13 fl vs 0.23 fl, and 9.6 fl vs 15.3 fl), respectively). Conversely, platelet distribution width and platelet large cell ratio were higher in malaria-infected patients than healthy adults (19.2% vs 15.3% and 0.35% vs 0.29%), respectively). Parasitemia levels had a moderately inverse correlation with platelet count (r= −0.419) and a weakly positive correlation with mean platelet volume (r=0.278). Conclusion The platelet, plateletcrit, and mean platelet volume of malaria-infected patients were significantly lower as compared with healthy adults. Malaria parasitemia had a moderate inverse correlation with platelet count and a weak positive correlation with mean platelet volume. Thrombocytopenia and alteration of platelet parameters should be considered in malaria patients.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Asmerom

Gemechu

Bete

et al. 2023

JBM

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“…Besides several preventive measures, treatment with antimalarial drugs is of immense importance in reducing the malarial infection . For the therapy of Plasmodium parasites, antimalarial drugs are inevitable and therefore, they are key tools for the control and elimination of malaria …”

Section: Introductionmentioning

confidence: 99%

Combination mode of antimalarial drug mefloquine and human serum albumin: Insights from spectroscopic and docking approaches

et al. 2019

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The interaction between mefloquine (MEF), the antimalarial drug, and human serum albumin (HSA), the main carrier protein in blood circulation, was explored using fluorescence, absorption, and circular dichroism spectroscopic techniques. Quenching of HSA fluorescence with MEF was characterized as static quenching and thus confirmed the complex formation between MEF and HSA. Association constant values for MEF‐HSA interaction were found to fall within the range of 3.79‐5.73 × 104 M˗1 at various temperatures (288, 298, and 308 K), which revealed moderate binding affinity. Hydrogen bonds and hydrophobic interactions were predicted to connect MEF and HSA together in the MEF‐HSA complex, as deduced from the thermodynamic data (ΔS = +133.52 J mol−1 K−1 and ΔH = +13.09 kJ mol−1) of the binding reaction and molecular docking analysis. Three‐dimensional fluorescence spectral analysis pointed out alterations in the microenvironment around aromatic amino acid (tryptophan and tyrosine) residues of HSA consequent to the addition of MEF. Circular dichroic spectra of HSA in the wavelength ranges of 200‐250 and 250‐300 nm hinted smaller changes in the protein's secondary and tertiary structures, respectively, induced by MEF binding. Noncovalent conjugation of MEF to HSA bettered protein thermostability. Site marker competitive drug displacement results suggested HSA Sudlow's site I as the MEF binding site, which was also supported by molecular docking analysis.

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Role of Platelet Indices as a Potential Marker for Malaria Severity

Bayleyegn

Asrie

Yalew

et al. 2021

Journal of Parasitology Research

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Purpose. Platelet parameter alteration such as platelet count and platelet indices are more common than in other blood cell lines due to diverse causative pathophysiological mechanisms in severe malaria infection. In malaria patients, no more studies evaluated platelet indices in relation to disease severity and prognosis. Therefore, this review assessed the current scientific knowledge on the potential role of platelet indices for the diagnostic marker of severe malaria infection. Results. Hence, after reviewing recent literatures, elevation of mean platelet volume and platelet distribution width in addition to decreased plateletcrit and platelet counts is the known potential risk factor associated with warning signs of severe malaria. Thus, thrombocytopenia < 150 × 10 9 / L , MPV ≥ 9.05 fL , and PDW ≥ 14.550 % as well as significantly higher P-LCR and decrease in PCT are shown significant sensitivity and specificity as they are used as diagnostic and prognostic values in severe malaria infection. Conclusion. Platelet indices are useful predictors of malaria severity. Immature platelet fraction (IPF%) is raised in the case of severe malaria, and it was significantly more useful than MPV. Advanced research will further investigate the platelet index abnormality associated with specific age and gender among specific malaria species.

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Correlation of Type of Species and Parasite Density in Malaria With Platelet Count, Mean Platelet Volume and Platelet Distribution Width

Cited by 3 publications

References 12 publications

Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Platelet Parameters and Their Correlation with Parasitemia Levels Among Malaria Infected Adult Patients at Jinella Health Center, Harar, Eastern Ethiopia: Comparative Cross-Sectional Study

Combination mode of antimalarial drug mefloquine and human serum albumin: Insights from spectroscopic and docking approaches

Role of Platelet Indices as a Potential Marker for Malaria Severity

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