A study of the spectral behaviour of Eosin dye in three states of metallosurfactants: Monomeric, micelles and metallosomes

Garg, Preeti; Kaur, Baljinder; Kaur, Gurpreet; Saini, Sakshi; Chaudhary, Ganga Ram

doi:10.1016/j.colsurfa.2020.125697

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…Stern–Volmer equation has been widely utilized to investigate the mechanism of fluorescence quenching. 35–37 The intensities of fluorescence of erythrosine B in the presence and absence of FLX ( F and F 0 , respectively) were plotted versus the molar concentration of the FLX [Q] according to the following equation: 38 F 0 / F = 1 + K SV [Q]where, K SV is the Stern–Volmer constant. Upon plotting the ratio, F 0 / F versus the molar concentration of drug, the Stern–Volmer plot was obtained which show a linear line.…”

Section: Resultsmentioning

confidence: 99%

“…Stern-Volmer equation has been widely utilized to investigate the mechanism of uorescence quenching. [35][36][37] The intensities of uorescence of erythrosine B in the presence and absence of FLX (F and F 0 , respectively) were plotted versus the molar concentration of the FLX [Q] according to the following equation: 38…”

Section: Mechanism Of Uorescence Quenchingmentioning

confidence: 99%

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A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

Derayea,

Oraby,

Zaafan

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Section: Mechanism Of Uorescence Quenchingmentioning

confidence: 99%

A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

Derayea,

Oraby,

Zaafan

et al. 2024

RSC Adv.

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“…9−12 Metallosurfactants employ multiple mechanisms simultaneously to combat pathogens, which include cellular membrane disruption, the generation of reactive oxygen species (ROS) via metal ion interactions, and degradation of cellular components such as DNA and enzymes. 13 While various metallosurfactants have been explored for antibacterial activities, comparative studies on their efficacy remain limited. Among metals, copper and iron have demonstrated capabilities in environmental remediation through redox reactions and ROS production.…”

Section: Introductionmentioning

confidence: 99%

“…Conventional cationic surfactants possess broad-spectrum antimicrobial and antifungal properties. , Owing to their vast potential, metallosurfactants are considered an alternative to traditional surfactants and thus, can be used as disinfectants against bacterial contamination and infections. − Metallosurfactants employ multiple mechanisms simultaneously to combat pathogens, which include cellular membrane disruption, the generation of reactive oxygen species (ROS) via metal ion interactions, and degradation of cellular components such as DNA and enzymes . While various metallosurfactants have been explored for antibacterial activities, comparative studies on their efficacy remain limited.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Photodynamic Therapy of the Metallosurfactant–Fluorescein Conjugate under Visible Light Illumination

Garg,

Sharma,

Sehgal

et al. 2024

ACS Appl. Bio Mater.

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Antibacterial photodynamic therapy (APDT) has received increased attention as a treatment for multidrug-resistant bacterial infections caused by antibiotic abuse. However, photosensitizers used in APDT have disadvantages such as water insolubility, self-aggregation, and photobleaching. To address these limitations, metal complexes have been explored. However, the use of such complexes tends to confine their antibacterial effectiveness specific bacterial strains. In this study, we report iron (Fe)-and copper (Cu)-based metallosurfactants as unique moieties for antibacterial photodynamic therapy (PDT) under the illumination of visible light. Briefly, our formulated Fe and Cu metallosurfactants, when combined with a fluorescein photosensitizer, exhibit nearly 100% antibacterial efficacy. This high efficiency is primarily attributed to the enhanced generation of singlet oxygen using FL in the presence of metallosurfactants when targeting bacteria such as Escherichia coli and Staphylococcus aureus under laser light. In vitro experiments further confirmed the superior antimicrobial activity of these metallosurfactants against a diverse range of microbial cultures, encompassing Gram-negative and Gram-positive bacteria as well as fungi. This performance outpaces conventional surfactants like cetyltrimethylammonium chloride and cetylpyridinium chloride. The compelling results from MTT assays and flow cytometry endorsed the substantial enhancement in antimicrobial properties achieved through Fe and Cu doping, all without the need for additional secondary agents. Notably, this synergistic antibacterial approach using metallosurfactants in PDT holds significant promise for the elimination of various bacteria in vivo, with the added advantage of mitigating the emergence of multidrug resistance.

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“…A broad range of nanomaterials such as carbon and metal-based nanomaterials, nanocomposites, dendrimers, polymers, nanoemulsions, micelles, liposomes, etc. have been shown to exhibit a remarkable antimicrobial properties (Chauhan et al, 2019;Kaur et al, 2019;Garg et al, 2020;Garg et al, 2021;Makabenta et al, 2021;Singh et al, 2022). They are considered more capable as compared to their micro/macroscale counterparts in terms of inhibiting microbial growth (Zare et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Advances and Perspective on Antimicrobial Nanomaterials for Biomedical Applications

Garg

Attri

Sharma

et al. 2022

Front. Nanotechnol.

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Microbial infection and antibiotic resistance is recognized as a serious problem to society from both an economical perspective and a health concern. To tackle this problem, “nanotechnology,” a multidisciplinary field of research, has provided a plethora of nanomaterials for potential applications in the antimicrobial sector. This letter discusses how antimicrobial nanomaterials are shaping this challenging field and being evaluated as therapeutic and medication delivery agents. The recently designed smart antimicrobial surfaces with switchable features that displayed synergistic antibacterial action were also highlighted. To end, we provide the current scenario and future perspectives with regards to emerging antimicrobial nano-engineered materials and nanotechnology.

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A study of the spectral behaviour of Eosin dye in three states of metallosurfactants: Monomeric, micelles and metallosomes

Cited by 6 publications

References 59 publications

A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

Antibacterial Photodynamic Therapy of the Metallosurfactant–Fluorescein Conjugate under Visible Light Illumination

Advances and Perspective on Antimicrobial Nanomaterials for Biomedical Applications

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