Advances and Perspective on Antimicrobial Nanomaterials for Biomedical Applications

Garg, Preeti; Attri, Prerna; Sharma, Rohit K.; Chauhan, Moondeep; Chaudhary, Ganga Ram

doi:10.3389/fnano.2022.898411

Cited by 17 publications

(9 citation statements)

References 36 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanomaterials with intrinsic antibacterial properties are proving to be promising broad-spectrum antimicrobial agents. [122,123] However, due to their low catalytic activity and poor bacterial capture capacity, their feasibility remains far from satisfactory. [23] In this section, we will look at how defect engineering can be used to make nanosystems more effective against Gram-negative and Gram-positive bacteria in vitro and in vivo.…”

Section: Defect-engineered Antimicrobial Nanosystemsmentioning

confidence: 99%

Defect Engineering in Biomedical Sciences

et al. 2023

View full text Add to dashboard Cite

With the promotion of nanochemistry research, large numbers of nanomaterials have been applied in vivo to produce desirable cytotoxic substances in response to endogenous or exogenous stimuli for achieving disease‐specific therapy. However, the performance of nanomaterials is a critical issue that is difficult to improve and optimize under biological conditions. Defect‐engineered nanoparticles have become the most researched hot materials in biomedical applications recently due to their excellent physicochemical properties, such as optical properties and redox reaction capabilities. Importantly, the properties of nanomaterials can be easily adjusted by regulating the type and concentration of defects in the nanoparticles without requiring other complex designs. Therefore, this tutorial review focuses on biomedical defect engineering and briefly discusses defect classification, introduction strategies, and characterization techniques. Several representative defective nanomaterials are especially discussed in order to reveal the relationship between defects and properties. A series of disease treatment strategies based on defective engineered nanomaterials are summarized. By summarizing the design and application of defective engineered nanomaterials, a simple but effective methodology is provided for researchers to design and improve the therapeutic effects of nanomaterial‐based therapeutic platforms from a materials science perspective.

show abstract

Section: Defect-engineered Antimicrobial Nanosystemsmentioning

confidence: 99%

Defect Engineering in Biomedical Sciences

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Nevertheless, these efforts have often yielded limited success due to the gain of resistance. Adding to the complexity of this challenge is the withdrawal of biopharmaceutical industries from the pursuit of novel antibiotics due to formidable economic and regulatory impediments, further accentuating the profound global healthcare predicament ( Garg et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Saravanan,

Subramani,

Rajaramon

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Nanocomposites, formed by combining a matrix (commonly polymer or ceramic) with nanofillers (nano-sized inclusions like nanoparticles or nanofibers), possess distinct attributes attributed to their composition. Their unique physicochemical properties and interaction capabilities with microbial cells position them as a promising avenue for infectious disease treatment. The escalating prevalence of multi-drug resistant bacteria intensifies the need for alternative solutions. Traditional approaches involve antimicrobial agents like antibiotics, antivirals, and antifungals, targeting specific microbial aspects. This review presents a comprehensive overview of diverse nanocomposite types and highlights the potential of tailored matrix and antibacterial agent selection within nanocomposites to enhance treatment efficacy and decrease antibiotic resistance risks. Challenges such as toxicity, safety, and scalability in clinical applications are also acknowledged. Ultimately, the convergence of nanotechnology and infectious disease research offers the prospect of enhanced therapeutic strategies, envisioning a future wherein advanced materials revolutionize the landscape of medical treatment.

show abstract

“…Tiwari et al provided an opinion article to project the importance of nano-enabled protective gear, gloves, masks, sheets, disinfectants, and filtration units to facilitate quarantine plans. [17] Gage et al reviewed the new variants of SARS-COV-2, their severe effects, and nano-enabled tools for virus eradication through nanoparticle-based air filters and purifiers. [18] Herein, the newly developed and commercial SARS-CoV-2 electrochemical biosensors are introduced.…”

Section: Introductionmentioning

confidence: 99%

Innovations and Challenges in Electroanalytical Tools for Rapid Biosurveillance of SARS‐CoV‐2

Ardalan

Ignaszak

2022

Adv Materials Technologies

View full text Add to dashboard Cite

Since the onset of the coronavirus disease 2019 (COVID‐19) pandemic, preventive social paradigms and vaccine development have undergone serious renovations, which drastically reduced the viral spread and increased collective immunity. Although the technological advancements in diagnostic systems for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) detection are groundbreaking, the lack of sensitive, robust, and consumer‐end point‐of‐care (POC) devices with smartphone connectivity are conspicuously felt. Despite its revolutionary impact on biotechnology and molecular diagnostics, the reverse transcription polymerase chain reaction technique as the gold standard in COVID‐19 diagnosis is not suitable for rapid testing. Today's POC tests are dominated by the lateral flow assay technique, with inadequate sensitivity and lack of internet connectivity. Herein, the biosensing advancements in Internet of Things (IoT)‐integrated electroanalytical tools as superior POC devices for SARS‐CoV‐2 detection will be demonstrated. Meanwhile, the impeding factors pivotal for the successful deployment of such novel bioanalytical devices, including the incongruous standards, redundant guidelines, and the limitations of IoT modules will be discussed.

show abstract

Advances and Perspective on Antimicrobial Nanomaterials for Biomedical Applications

Cited by 17 publications

References 36 publications

Defect Engineering in Biomedical Sciences

Defect Engineering in Biomedical Sciences

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Innovations and Challenges in Electroanalytical Tools for Rapid Biosurveillance of SARS‐CoV‐2

Contact Info

Product

Resources

About