A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

Derayea, Sayed M.; Oraby, Mohamed; Zaafan, Al Amir S.; Hamad, Ahmed Abdulhafez; Nagy, Dalia M.

doi:10.1039/d3ra08257a

RSC Adv.

2024

DOI: 10.1039/d3ra08257a

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A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

Sayed M. Derayea,

Mohamed Oraby,

Al Amir S. Zaafan

et al.

Abstract: Ion pair complex formation between fluvoxamine and erythrosine B dye quench the fluorescence of the dye in a concentration dependent profile.

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Cited by 3 publications

References 43 publications

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Exploitation of erythrosine B as a fluorometric marker for lurasidone determination through electrostatic attraction; application to content uniformity test

Elhamdy,

Oraby,

Derayea

et al. 2024

Luminescence

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A recently developed antipsychotic drug, lurasidone, was determined using a simple, sensitive, and eco‐friendly spectrofluorimetric approach. The suggested approach was based on the quantifiable quenching impact of lurasidone on the inherent fluorescence of erythrosine B in an acidic environment employing a Teorell–Stenhagen buffer (pH 4). Following excitation at 530 nm, the quenching of erythrosine B fluorescence was monitored at 552 nm. The system variables were systematically optimized to enhance the formation of the lurasidone‐erythrosine B ion pair for analytical purposes. A linear calibration graph was built in the range of 20–600 ng mL−1 with 0.9998 as a coefficient of correlation. The quantitation and detection limits were 13.5 and 4.5 ng/mL, respectively. The analytical validity of the designed approach was assessed with respect to International Council on Harmonization (ICH) guiding principles. The proposed methodology was employed with high recoveries for assessing lurasidone in bulk powder and its therapeutic tablet dosage form. Additionally, the uniformity of tablet formulations was tested using the developed approach. Finally, the established approach was assessed for its greenness using various tools.

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Exploitation of erythrosine B as a fluorometric marker for lurasidone determination through electrostatic attraction; application to content uniformity test

Elhamdy,

Oraby,

Derayea

et al. 2024

Luminescence

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Evaluation of the on–off fluorescence method for facile measurement of vilazodone in pharmaceutical dosage form; Application to content uniformity testing and greenness evaluation

Amir S. Zaafan,

Derayea,

Nagy

et al. 2024

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Development and validation of a precise flow injection method for the assessment of brexpiprazole, with application to pharmaceutical dosage forms and human plasma analysis

Derayea,

Zaafan,

Nagy

et al. 2024

BMC Chemistry

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A novel antipsychotic medication named brexpiprazole (BRX) is currently employed for the treatment of schizophrenia and other psychotic disorders. Because BRX’s molecular structure includes a benzothiophene ring, it natively fluoresces. To detect BRX with precision and speed, a flow injection-fluorometric method, which is both sensitive and selective, is recommended. The fluorescence detection was conducted at 364 nm following excitation at 326 nm to capture the strong intrinsic fluorescence of BRX. The carrier solution employed was a mixture of phosphate buffer (pH 4, 10 mM) and acetonitrile (50: 50, v/v), with a flow rate of 0.5 mL min− 1. The calibration curve, based on peak areas, exhibited linearity within the concentration range of 20–350 ng mL− 1, with a remarkable correlation coefficient (r2) of 0.9999. The limit of quantitation was 9.7 ng mL− 1, and the limit of detection was found to be 3.2 ng mL− 1. This method was applied to quantify BRX in Neopression® tablets, achieving recovery within an acceptable range without interference from the tablet’s additives. Additionally, the proposed approach was successfully utilised to quantify the drug in spiked human plasma. The approach underwent validation following ICH requirements.

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A facile on–off fluorescence approach for fluvoxamine determination in pharmaceutical tablets; application to content uniformity testing

Abstract: Ion pair complex formation between fluvoxamine and erythrosine B dye quench the fluorescence of the dye in a concentration dependent profile.

Cited by 3 publications

References 43 publications

Exploitation of erythrosine B as a fluorometric marker for lurasidone determination through electrostatic attraction; application to content uniformity test

Exploitation of erythrosine B as a fluorometric marker for lurasidone determination through electrostatic attraction; application to content uniformity test

Evaluation of the on–off fluorescence method for facile measurement of vilazodone in pharmaceutical dosage form; Application to content uniformity testing and greenness evaluation

Development and validation of a precise flow injection method for the assessment of brexpiprazole, with application to pharmaceutical dosage forms and human plasma analysis

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