A study of the reticulum and of luteinization in granulosa and theca cell tumors of the ovary

Traut, Herbert F.; Kuder, Alberta; Cadden, J.F.

doi:10.1016/s0002-9378(39)90880-x

Cited by 28 publications

(1 citation statement)

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“…The 2-cell, 2-gonadotropin theory has been applied to granulosa cell tumors. Many of these tumors have luteinized theca-like cells in the stroma, and these so-called theca reaction cases tend to show hormonal symptoms [ 12 ]. Typical granulosa tumor cells lack the ability to produce these hormones, whereas cells with a clear cytoplasm express steroid synthesis enzymes and are the source of hormones in granulosa cell tumors [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes

et al. 2017

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ObjectiveSome, but not all, granulosa cell tumors are characterized by estrogen production. This study was designed to determine whether there are clinical or pathological variations in granulosa cell tumors in relation to the expression of sex steroid synthesis enzymes.MethodsClinical symptoms, serum hormonal values, and histology of 30 granulosa cell tumor patients who underwent surgery between 2002 and 2014 were retrospectively reviewed.ResultsMost patients presented with abnormal genital bleeding including abnormal menstrual cycles. Eight of 16 patients older than 50 years had endometrial hyperplasia and one had endometrial cancer. Serum 17β-estradiol (E2) levels tended to be higher in patients over 50 years of age (p=0.081). Serum follicle-stimulating hormone (FSH) levels were low in all patients irrespective of serum E2 levels. Magnetic resonance imaging revealed a thicker endometrium in older as compared to younger patients (p<0.05). Tumor cells in the majority of cases were positive for inhibin α and P450 aromatase, irrespective of age and serum E2 levels. P450 17α-hydroxylase (P450c17) expression varied among cases. P450c17 was strongly positive in luteinized tumor cells and weakly positive in theca cells and fibroblasts. High E2 levels were associated with P450c17-positive cells in the tumor (p<0.05).ConclusionThe expression of hormone-synthesizing enzymes divides granulosa cell tumors into 2 distinct types; tumors with P450c17-positive cells show elevated serum E2 and related clinical symptoms, while tumors without these cells show symptoms related to FSH suppression by inhibin.

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Section: Discussionmentioning

confidence: 99%