Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes

Kitamura, Shinji; Abiko, Kaoru; Matsumura, Noriomi; Akimoto, Yumiko; Tanimoto, Hirotoshi; Konishi, Ikuo

doi:10.3802/jgo.2017.28.e31

Cited by 14 publications

(8 citation statements)

References 13 publications

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“…Estrogen production can also lead to endometrial abnormalities, according to the literature, the incidence of endometrial carcinoma varies from 3% to 22%, and endometrial hyperplasia varies from 32% to 85% [11]. Kitamura S et al [12] found, in their series, 8 cases (out of 16) of endometrial hyperplasia and one case of endometrial carcinoma associated with granulosa cell tumors adult type. In our study, the patient underwent right adnexectomy only and the endometrium could not be assessed.…”

Section: Discussionmentioning

confidence: 98%

Adult Granulosa Cell Tumor in a Young Woman: A Case Report and Literature Review

Raivoherivony¹,

Rakotondrainibe²,

Nomenjanahary³

et al. 2020

OJPathology

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Granulosa cell tumors belong to the group of stromal and sex cord tumors of the ovary. The adult type is the most common type and usually occurs during the perimenopausal period while the juvenile type mostly affects young women. This is a report of a 26 years old woman who presented an adult type of granulosa cells tumor, with review of the literature. She complained abdominal pain and distension associated with abundant ascites and underwent a right adnexectomy. The pathology examination diagnosed an adult granulosa cell tumor. The two entities of granulosa cell tumors (juvenile and adult types) are distinguished by their characteristic morphological aspects on histological examination allowing diagnostic orientation.

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Section: Discussionmentioning

confidence: 98%

Adult Granulosa Cell Tumor in a Young Woman: A Case Report and Literature Review

Raivoherivony¹,

Rakotondrainibe²,

Nomenjanahary³

et al. 2020

OJPathology

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“…Extremely rare examples of virilizing, testosterone-producing JGCT are reported in the literature (2-3% of GCTs) and manifest with hirsutism, amenorrhea, deepening of the voice, clitoral hypertrophy and acne [6]. In contrast, AGCTs usually present with menstrual irregularities, amenorrhea and endometrial hyperplasia [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis

Inzani

Santoro

Travaglino

et al. 2021

Arch Gynecol Obstet

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Background Ovarian adult granulosa cell tumours are low-grade malignant sex cord-stromal neoplasm with a low recurrence rate. Prognostic factors for recurrence include tumor stage, tumor rupture in Stage I neoplasms and the presence of residual tumors after surgery. However, in recurrent tumors, prognostic factors for overall survival (OS) are lacking. In the present paper, we conducted a systematic meta-analysis with the aim to assess prognostic factors for OS in patients with recurrent GCT. Methods Electronic databases were searched for all studies assessing prognostic factors in recurrent adult granulosa cell tumor of the ovary. Student T test, Fisher's exact test and Kaplan-Meier survival analysis with long-rank test were used to assess differences among groups; a p value < 0.05 was considered significant. Results Eleven studies analyzing 102 recurrent tumors were included in the systematic review. Tumor stage and localization of recurrent tumors were significantly associated with OS on Kaplan-Meier analysis; Cox regression analysis showed a HR of 0.879 for the stage II, of 3.052 for the stage III, and of 2.734 for stage IV tumor was significantly associated with OS (p = 0.037); observed HRs for abdominal and thoracic locations were of 2.405 and of 4.024, respectively. Conclusions In conclusion, the present article emphasizes the prognostic significance of tumor stage > II and extrapelvic anatomic sites of recurrences in patients with recurrent granuolase cell tumors of the ovary.

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“…Ovarian GC tumors are one of the most common ovarian tumors, mainly causing abnormal estrogen secretion ( 94 ) ( Fig. 3 ).…”

Section: Changes In Aromatase Activity Of Gcs Induce Diseasesmentioning

confidence: 99%

Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells (Review)

2021

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Ovarian granulosa cells (Gcs) are the most important source of estrogen. Therefore, aromatase (estrogen synthase), which is the key enzyme in estrogen synthesis, is not only an important factor of ovarian development, but also the key to estrogen secretion by Gcs. disorders of the ovarian estrogen secretion are more likely to induce female estrogen-dependent diseases and fertility issues, such as ovarian cancer and polycystic ovary syndrome. Hence, aromatase is an important drug target; treatment with its inhibitors in estrogen-dependent diseases has attracted increasing attention. The present review article focuses on the regulation and mechanism of the aromatase activity in the Gcs, as well as the specific regulation of aromatase promoters. In GCs, follicle-stimulating hormone (FSH) is dependent on the cyclic adenosine monophosphate (cAMP) pathway to regulate the aromatase activity, and the regulation of this enzyme is related to the activation of signaling pathways, such as phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (ERK). In addition, endocrine-disrupting substance and other related factors affect the expression of aromatase, which eventually create an imbalance in the estrogen secretion by the target tissues. The present review highlights these useful factors as potential inhibitors for target therapy.

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Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes

Cited by 14 publications

References 13 publications

Adult Granulosa Cell Tumor in a Young Woman: A Case Report and Literature Review

Adult Granulosa Cell Tumor in a Young Woman: A Case Report and Literature Review

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis

Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells (Review)

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