A Study of the Photosensitive Factor in Relation to Skin Lesions of Mycosis fungoides Patients

Abstract

Some mycosis fungoides patients show abnormal light reactions in apparently normal skin. Clinically it is observed that lesional skin most easily burned during photochemotherapy. For this reason phototests to broad wavelength regions were performed in 9 mycosis fungoides patients, close to skin lesions and at 3 and 10 cm from cutaneous lesions. The light doses giving the minimal erythemal dose, were of about the same magnitude at a distance of 3 and 10 cm from the lesions. One third of the patients showed abnormal reactions following UVA and UVB. More abnormal reactions were seen close to lesional skin, and a displacement towards increased light sensitivity was demonstrated.

Normalized light reactions in mycosis fungoides patients after complete remission of skin lesions

“…age range 45-72 years. Five of them are reported in a previous paper ( 10). All patients had clinical cutaneous lesions of mycosis fungoides and the diagnos is was confirmed histologically, before treatment was started.…”

“…The photosensitive reactions are most abnorma! on the border of skin lesions ( 10). A practical consequem:e of the low erythemal threshold is that caution must be taken when treat-ing these patients with photochemotherapy.…”

“…Light tests were performed before the treatment was slarted and after achieving complete remission of all skin lesions. The light testing procedure and the filters used are recorded elsewhere ( 10).…”

“…3--6). Experimentally it is shown that the erythemal threshold in apparently normal skin is lowest close to cutaneous lesions ( 10). These observations are impo11ant, considering the in creasing use of PUV A treatment in mycosis fungoi des patients.…”

Successful treatment of actinic reticuloid induced by whole-body topical application of mechlorethamine

“…Abnorma! photosensitivity is most pronounced on the border of and on lesional skin in mycosis fungoides pa tients (6).…”