Mycosis fungoides

Sterry, Wolfram

doi:10.1007/978-3-642-69574-2_5

Cited by 20 publications

(8 citation statements)

References 179 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the additional biopsies obtained from the CTCL patients, typical histological findings of MF or CD30 π pleomorphic T-cell lymphoma (5,6) were demonstrated. Some diversity within the cellular composition was found between the biopsies.…”

Section: Correlation With Histological and Immunohistochemical Findingsmentioning

confidence: 91%

“…Skin punch biopsies (4 to 8 mm) were obtained from lesional skin of adult patients with currently untreated CTCL (nΩ19) and psoriasis (nΩ10). The material from CTCL patients consisted of samples from patch (nΩ7), and plaque (nΩ6) stage MF (corresponding to stage IA-IIB of the EORTC classification) as well as CD30 π pleomorphic T-cell lymphoma (nΩ6) as determined by clinical and histological criteria (5,6). An additional biopsy was obtained from these CTCL patients for histological and immunohistochemical examination.…”

Section: Biopsy Specimens Cell Linesmentioning

confidence: 99%

“…The histological investigations (H&E and Giemsa staining) included the evaluation of the main criteria for the diagnosis of the respective CTCL entity (5,6). Immunohistochemical investigations were carried out by standard procedures, using monoclonal antibodies against CD1a, CD3, CD4, CD8, CD30, CD68, CD79a (all Dako, Hamburg, Germany).…”

Section: Histology and Immunohistochemistrymentioning

confidence: 99%

See 2 more Smart Citations

IL‐15 and IL‐16 overexpression in cutaneous T‐cell lymphomas: stage‐dependent increase in mycosis fungoides progression

Asadullah¹,

Haeussler-Quade²,

Gellrich³

et al. 2000

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

Cytokines are of major importance for the pathogenesis of cutaneous T-cell lymphomas (CTCL). Recent data suggested that IL-15 and IL-16 are survival/growth factors for the malignant T cells in these entities. To investigate the expression of IL-15 and IL-16 in mycosis fungoides (MF) and CD30+ pleomorphic T-cell lymphoma in vivo, we established a competitive RT-PCR technique. Analyzing skin biopsies from CTCL patients at different stages in comparison to psoriatic and healthy skin, we found IL-15 and IL-16 mRNA overexpression in both CTCL entities. Remarkably, there was some evidence for a stage-dependent increase during MF progression. We found only slight overexpression in early stage MF, when only few tumor cells are detectable within the infiltrates, whereas marked overexpression was found in more advanced lesions, which are characterized by a higher density of malignant cells. These results suggested that CTCL cells themselves might produce the cytokines. To further elucidate this hypothesis, two CTCL cell lines were analyzed but gave conflicting results. Therefore, the cellular origin of the IL-15 and IL-16 overexpression in CTCL remains unclear. Considering the significant overexpression of IL-15 and IL-16 and their biological capacities it is likely that these cytokines contribute to the tumor development. So, they might be involved in growth and skin homing of CTCL cells.

show abstract

Section: Correlation With Histological and Immunohistochemical Findingsmentioning

confidence: 91%

Section: Biopsy Specimens Cell Linesmentioning

confidence: 99%

Section: Histology and Immunohistochemistrymentioning

confidence: 99%

See 1 more Smart Citation

IL‐15 and IL‐16 overexpression in cutaneous T‐cell lymphomas: stage‐dependent increase in mycosis fungoides progression

Asadullah¹,

Haeussler-Quade²,

Gellrich³

et al. 2000

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mycosis fungoides (MF) is a helper T cell lymphoma of low-grade malignancy. It originates in the skin with eczematous patches which then morphologically transform to infiltrated plaques and finally may become ulcerated tumours [1,2]. Histologically, the plaque stage exhibits the most characteristic findings of MF: small lymphocytes with a cerebriform nucleus aggregate within the epidermis, forming Pautrier's microabscesses.…”

Section: Introductionmentioning

confidence: 99%

Analysis of VH genes rearranged by individual B cells in dermal infiltrates of patients with mycosis fungoides

Förste

Gellrich

Golembowski

et al. 1997

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYIn patients with cutaneous T cell lymphomas such as mycosis fungoides B cells can frequently be detected in the lymphocytic dermal infiltrate. To analyse their immunoglobulin heavy chain gene repertoire, single B cells were obtained from tissue sections of two typical patients with mycosis fungoides using hydraulic micromanipulation followed by specific amplification of the respective gene segments by single-cell polymerase chain reaction (PCR) technique. A total of 21 V H DJ H genes was sequenced. From each individual B cell a single productive V H DJ H rearrangement was obtained. There was no clonal relationship detected between any of these rearrangements suggesting polyclonality of the infiltrating B cells. The representation of V H families was in accordance with the germ-line complexity. A remarkably high number of V H genes (5/13 in patient 1; 3/8 in patient 2) was completely or nearly germ-line-identical. Five of seven V H 4 family genes were nearly unmutated. On the other hand, most of the V H 3 gene family members were somatically mutated in an antigen-driven manner. The proportion of germ-line-identical V H genes, the usage of individual V H , D, J H gene elements, and the pattern of somatic mutations found in the B cells infiltrating skin lesions of patients with mycosis fungoides resembles the peripheral blood repertoire, suggesting a bystander role of these cells.

show abstract

“…Only in patch stage MF, but not in the more advanced stages, IFN-g mRNA was detected with a significantly higher frequency than in healthy skin (18). The lack of IFN-g detection in advanced MF stages might explain the observation, that progression of the disease into tumor stage often results in a loss of epidermotropism (43). On the other hand, however, Sarris et al (16) detected IP-10 also in advanced MF stages, for which we excluded high IFN-g expression in our samples.…”

Section: Cytokine Expression As Reason For Epidermotropismmentioning

confidence: 91%

Cytokines and cutaneous T‐cell lymphomas

Asadullah

Döcke

Volk

et al. 1998

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

Cytokines are considered to be of major importance for the University Berlin, Germany pathogenesis of cutaneous T-cell lymphomas (CTCL). Their impact may result from autocrine, paracrine or endocrine effects. Several investigations demonstrated the overexpression of different cytokines in different CTCL entities. Interestingly, stage-dependent shifts in the cytokine pattern have been observed in mycosis fungoides (MF). There is evidence that the abnormal cytokine expression in CTCL might be responsible for tumor progression, resulting from an enhanced proliferation of the malignant cells and/or the depression of the anti-tumor immune response.

show abstract

Mycosis fungoides

Cited by 20 publications

References 179 publications

IL‐15 and IL‐16 overexpression in cutaneous T‐cell lymphomas: stage‐dependent increase in mycosis fungoides progression

IL‐15 and IL‐16 overexpression in cutaneous T‐cell lymphomas: stage‐dependent increase in mycosis fungoides progression

Analysis of VH genes rearranged by individual B cells in dermal infiltrates of patients with mycosis fungoides

Cytokines and cutaneous T‐cell lymphomas

Contact Info

Product

Resources

About