A Study of the Pancreatic Response to Histamine in Dogs with Total Gastrectomies

Tankel, H. I.; Lester, Louis J.; Richman, A; Hollander, Franklin

doi:10.1016/s0016-5085(57)80060-2

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…There is good evidence that the pyloric antrum as well as the small intestine is the source of humoral pancreatic stimulants (Blair, Brown, Harper & Scratcherd, 1966), and we do not know of any observations on basal pancreatic secretion in the dog in which the whole hormone-yielding area has been removed. It may be that in the dog also agents such as histamine, which Tankel, Lester, Richman & Hollander (1957) regard as a direct stimulant of pancreatic cells, in fact potentiate pancreatic secretion by a vasodilator action, which increases the supply of a humoral stimulant.…”

Section: Potentiation Of Secretinmentioning

confidence: 99%

Potentiation of secretin stimulation of the pancreas

Brown¹,

Harper²,

Scratcherd³

1967

The Journal of Physiology

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1. In fasted anaesthetized cats which were secreting pancreatic juice at a steady slow rate in response to continuous intravenous infusion of secretin, stimulation of the dorsal vagus trunk increased the rate of secretion, the rate of output of amylase and the concentration of bicarbonate in the juice.2. The increase in rate of secretion and in concentration of bicarbonate was reduced but not abolished by atropine. It was unaffected by adrenergic blocking agents, but abolished by hexamethonium.3. No increase in rate of secretion of secretin-stimulated juice was observed on cervical stimulation of vagus nerves in which the efferent fibres had degenerated after supra-nodose section of the nerves. It is concluded that the increase in secretion rate is mediated by ;atropine-resistant' efferent vagal fibres.4. Pancreozymin, antral extracts and histamine increased the rate of secretion of secretin-stimulated juice. Pancreozymin and antral extracts also increased the rate of amylase output. These effects of pancreozymin and antral extracts were not abolished by atropine or hexamethonium.5. As vagal stimulation pancreozymin, antral extracts and histamine have little or no effect on the resting pancreas of the anaesthetized cat, it is concluded that they exert a potentiating effect on secretin. It is suggested that the mechanism of this potentiation is an increase in pancreatic blood flow, which facilitates the supply of secretin to the gland.

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Section: Potentiation Of Secretinmentioning

confidence: 99%

Potentiation of secretin stimulation of the pancreas

Brown¹,

Harper²,

Scratcherd³

1967

The Journal of Physiology

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“…It was previously shown by Lorenz, Haubensak, Hutzel & Werle (1968) in the dog that pancreatic juice obtained by stimulation with secretin and pilocarpine contains high concentrations of histamine which remain constant during the secretion period. Exogenous application of histamine seems to have stimulatory effects on pancreatic secretion in dog (Tankel, Lester, Richman & Hollander, 1957;Lorenz et al 1968;Satoh, Satoh & Honda, 1980), pig (Hickson, 1970) and in vitro rabbit pancreas (Liebow & Franklin, 1982). It has also been demonstrated that histamine increases dog pancreatic secretion by activation of H2 receptors on pancreatic cells (Iwatsuki, Ikeda & Chiba, 1981).…”

Section: Introductionmentioning

confidence: 98%

Role of histamine receptors in rabbit pancreatic exocrine secretion stimulated by cholecystokinin and secretin

Pariente¹,

Madrid²,

Salido³

1990

Experimental Physiology

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SUMMARYAn investigation was made of the effects of HI and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The HI agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzyme output were also noted after H2 antagonist cimetidine. In contrast, the HI antagonist chlorpheniramine and H2 agonist dimaprit caused reductions in flow and enzyme output. The results suggest that HI receptors have stimulative effects and H2 receptors have inhibitory effects on exocrine rabbit pancreas.

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“…The involvement of histamine as a secretagogue in the control of exocrine pancreatic secretion is unclear because of the apparent species variability in sensitivity to histamine (Leibow & Franklin, 1982). There is some evidence that histamine can act as a secretagogue in both the anaesthetized dog and rabbit (Tankel, Lester, Richman & Hollander, 1957;Pariente, Madrid & Salido, 1989) as well as on the rabbit pancreas in vitro (Leibow & Franklin, 1982). In contrast, histamine is less effective as a secretagogue in the anaesthetized rat (Chariot, Roz6 & Vaille, 1979) and has no detectable effect on digestive enzyme secretion in lobules of the guinea-pig pancreas (Leibow & Franklin, 1982).…”

Section: Introductionmentioning

confidence: 99%