Histamine‐evoked amylase secretion is associated with small changes in calcium mobilization in isolated guinea‐pig pancreas

Salido, Ginés M.; Lennard, Roger; Singh, J.; Pariente, JA

doi:10.1113/expphysiol.1990.sp003401

Cited by 11 publications

(11 citation statements)

References 8 publications

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“…Although Harvey and Owen [24] demonstrated vascular effects for histamine, it is worth noting that there was no sustained disturbance in blood pressure during the experiments. Moreover, previous studies have demonstrated that histamine can elicit an increase in amylase secretion from pancreatic segments [14], lobules [3,15] and acinar cells [8]. Nevertheless, we cannot reject that a part of the effects observed in this study may be due to changes in the mesenteric circulation.…”

Section: Discussioncontrasting

confidence: 68%

“…A. Pariente significant rise in enzyme secretion. Similar findings have been obtained by us in guinea-pig pancreatic segments [8,14] and lobules [15]. Furthermore, Lorenz et al [12] showed that the dog pancreatic juice obtained by stimulation by secretin and pilocarpine contains histamine in a high concentration which is constant during the whole secretion period.…”

Section: Introductionsupporting

confidence: 79%

“…Pancreatic tissues have an average histamine content of 1.3 gg/g; a value which is three times the histamine content of skeletal muscle and one-eighth the content of stomach fundus [3]. Previous studies on exocrine pancreatic secretion have demonstrated that histamine can act as a secretagogue in both the anaesthetised dog and rabbit [5-7, 12, 13] as well as on the rabbit and guinea pig pancreas "in vitro" [3,8,14,15]. The present study has demonstrated that the paracrine agent histamine can also elicit an increase on exocrine pancreatic secretion in anaesthetised guinea pig.…”

Section: Discussionmentioning

confidence: 99%

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Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

et al. 1995

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The effects of histamine upon secretin- or cholecystokinin (CCK)-evoked exocrine pancreatic secretion were investigated in the anaesthetised guinea pig. Histamine (0.1 mumol/kg/min) induced a slight increase in pancreatic juice flow and total protein release compared to saline controls. Secretin (0.5 pmol/kg/min) and CCK-8 (0.75 pmol/kg/min) evoked marked time course increases in both the rate of pancreatic juice flow and total protein output in the anaesthetised guinea pig. Administration of either secretin or CCK-8 simultaneously with histamine elevated the exocrine pancreatic secretion compared to the smaller response obtained when administered separately. These results indicate that histamine may play an important physiological role in modulating the hormonal control of exocrine guinea pig pancreas.

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Section: Discussioncontrasting

confidence: 68%

Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

et al. 1995

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“…Similarly, the para crine hormone can also evoke amylase out put in the isolated rabbit pancreas [6] and guinea pig pancreatic segments [11]. In ail these studies little or no attempt was made to determine the cellular mechanism of action of histamine on pancreatic acinar cells.…”

Section: Introductionmentioning

confidence: 99%

Activation of Histamine Receptors is Associated with Amylase Secretion and Calcium Mobilization in Guinea-Pig Pancreatic Acinar Cells

Pariente

Singh

Salido

et al. 1991

Cell Physiol Biochem

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An investigation was made on the effects of histamine and related receptor agonists and antagonists on amylase secretion and Ca²⁺ mobilization in isolated guinea pig pancreatic segments and acinar cells. The effect of acetylcholine (ACh) was examined for comparison. Histamine evoked marked dose-dependent increases in amylase secretion and small changes in 45Ca²⁺ efflux, 45Ca²⁺ influx and intracellular free Ca²⁺ concentration [Ca²⁺]i, compared to much larger responses obtained with ACh. The H₁ receptor agonist 2-thiazolyl-ethylamine (2-TEA) elicited a small increase in amylase secretion, whereas the H₂ receptor agonist dimaprit had little or no effect. Similarly, 2-TEA evoked only small increases in Ca²⁺ mobilization, whereas dimaprit had no detectable effect. The H₂ receptor antagonist oxmetidine also stimulated amylase output in a dose-dependent manner, similar in magnitude to histamine, whereas the H₁ receptor antagonist chlorpheniramine (CPR) was only effective as a secretagogue at 10^–2 M The H₁ antagonist also completely abolished the secretory responses of 2-TEA and markedly reduced the histamine-induced amylase secretion. The results demonstrate the involvement of histamine receptors in the control of amylase secretion and Ca²⁺ mobilization in guinea pig pancreatic acinar cells.

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“…Histamine can stimulate pancreatic juice secretion in the isolated dog pancreas [31], the anaesthetized dog [32,33], rabbit and guinea-pig [23,[34][35][36] but it is less effective as a secretagogue in the anaesthetized rat [37] and conscious dog [38]. In the in vitro pancreatic lobules of rabbit [28], segments of guinea pig [39,40] and rat [41] histamine can evoke marked increases in amylase secretion. Similarly, in guinea pig pancreatic acini the paracrine hormone can stimulate amylase output in a dose-dependent manner with maximal effect at 10 ¹3 M [30,42].…”

Section: Effect Of Histaminementioning

confidence: 99%

The physiological role of histamine in the exocrine pancreas

Singh

Pariente

Salido

1997

Inflammation Research

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In addition to the autonomic nervous system and gut hormones, the mast cell mediator histamine has also been associated with exocrine pancreatic secretion. This review is concerned with the distribution and the physiological role of histamine in the control of pancreatic juice secretion. Histamine is distributed widely around blood vessels and acinar tissues in the pancreas and it is released in pancreatic juice during secretagogue stimulation. Histamine has a marked secretagogue effect in the exocrine pancreas of several animal species but in many cases the secretory effect is gender-related. The paracrine hormone exerts its secretory response via activation of H1 and H2 receptors on pancreatic acinar cells to mobilize potassium ions (K+) and cellular calcium (Ca2+) and through elevation of endogenous adenosine 3',5' cyclic monophosphate (cyclic AMP) levels, respectively. A physiological role for H3 receptors has also been associated with exocrine pancreatic secretion. H3 receptors are located presynaptically on parasympathetic nerve terminals to control the release of acetylcholine via restriction of Ca2+ access into nerve terminal through the N-type Ca2+ channel. Taken together, the results presented in this review strongly support histamine as a potential modulator of exocrine pancreatic function.

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Histamine‐evoked amylase secretion is associated with small changes in calcium mobilization in isolated guinea‐pig pancreas

Abstract: SUMMARYAn investigation was made of the effect of histamine on amylase secretion and calcium mobilization in isolated guinea-pig pancreatic segments. The effect of acetylcholine (ACh)

Cited by 11 publications

References 8 publications

Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

Activation of Histamine Receptors is Associated with Amylase Secretion and Calcium Mobilization in Guinea-Pig Pancreatic Acinar Cells

The physiological role of histamine in the exocrine pancreas

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