Role of histamine receptors in rabbit pancreatic exocrine secretion stimulated by cholecystokinin and secretin

Pariente, JA; Madrid, J.A.; Salido, Ginés M.

doi:10.1113/expphysiol.1990.sp003444

Cited by 7 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, the results of this study, taken together with the findings in our previous studies [7,15], provide further evidence that histamine is of physiological importance in the control of exocrine pancreatic secretion because it can modulate the response to the two main pancreatic secretagogue, secretin and CCK. The present results also indicate that the effect of histamine on pancreatic secretion may not be due to a non-specific effect.…”

Section: Discussionsupporting

confidence: 55%

“…The pattern of the secretory response to CCK clearly differed from that evoked by secretin. The sustained increase in flow accompanied by smaller increases in the total protein release caused by secretin is typical of its effect in other species [7,23] while the fluid response evoked by CCK is typical of its action on acinar enzyme secretion.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

et al. 1995

View full text Add to dashboard Cite

The effects of histamine upon secretin- or cholecystokinin (CCK)-evoked exocrine pancreatic secretion were investigated in the anaesthetised guinea pig. Histamine (0.1 mumol/kg/min) induced a slight increase in pancreatic juice flow and total protein release compared to saline controls. Secretin (0.5 pmol/kg/min) and CCK-8 (0.75 pmol/kg/min) evoked marked time course increases in both the rate of pancreatic juice flow and total protein output in the anaesthetised guinea pig. Administration of either secretin or CCK-8 simultaneously with histamine elevated the exocrine pancreatic secretion compared to the smaller response obtained when administered separately. These results indicate that histamine may play an important physiological role in modulating the hormonal control of exocrine guinea pig pancreas.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 97%

Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

et al. 1995

View full text Add to dashboard Cite

show abstract

“…It is well established that pancreatic juice secretion is controlled mainly by the auto nomic nervous system [1][2][3] as well as by the gut hormones such as secretin and cholecystokinin [4], However, recent studies have demonstrated that the paracrine hormone histamine is released in a high concentration in pancreatic juice [5], and that it has a marked secretagogue effect on the pancreas [6][7][8][9][10][11][12], although there is some species vari ability to its sensitivity [6], Histamine can stimulate pancreatic juice secretion in the isolated dog pancreas [7] and anesthetised rabbit [8,9], but it is less effective in the anaesthetised rat [10]. Similarly, the para crine hormone can also evoke amylase out put in the isolated rabbit pancreas [6] and guinea pig pancreatic segments [11].…”

Section: Introductionmentioning

confidence: 99%

Activation of Histamine Receptors is Associated with Amylase Secretion and Calcium Mobilization in Guinea-Pig Pancreatic Acinar Cells

Pariente

Singh

Salido

et al. 1991

Cell Physiol Biochem

View full text Add to dashboard Cite

An investigation was made on the effects of histamine and related receptor agonists and antagonists on amylase secretion and Ca²⁺ mobilization in isolated guinea pig pancreatic segments and acinar cells. The effect of acetylcholine (ACh) was examined for comparison. Histamine evoked marked dose-dependent increases in amylase secretion and small changes in 45Ca²⁺ efflux, 45Ca²⁺ influx and intracellular free Ca²⁺ concentration [Ca²⁺]i, compared to much larger responses obtained with ACh. The H₁ receptor agonist 2-thiazolyl-ethylamine (2-TEA) elicited a small increase in amylase secretion, whereas the H₂ receptor agonist dimaprit had little or no effect. Similarly, 2-TEA evoked only small increases in Ca²⁺ mobilization, whereas dimaprit had no detectable effect. The H₂ receptor antagonist oxmetidine also stimulated amylase output in a dose-dependent manner, similar in magnitude to histamine, whereas the H₁ receptor antagonist chlorpheniramine (CPR) was only effective as a secretagogue at 10^–2 M The H₁ antagonist also completely abolished the secretory responses of 2-TEA and markedly reduced the histamine-induced amylase secretion. The results demonstrate the involvement of histamine receptors in the control of amylase secretion and Ca²⁺ mobilization in guinea pig pancreatic acinar cells.

show abstract

“…It is similar in efficacy as secretin but slightly more potent than comparable stimulant as vasoactive intestinal polypeptide (VIP) [29,30]. Histamine can stimulate pancreatic juice secretion in the isolated dog pancreas [31], the anaesthetized dog [32,33], rabbit and guinea-pig [23,[34][35][36] but it is less effective as a secretagogue in the anaesthetized rat [37] and conscious dog [38]. In the in vitro pancreatic lobules of rabbit [28], segments of guinea pig [39,40] and rat [41] histamine can evoke marked increases in amylase secretion.…”

Section: Effect Of Histaminementioning

confidence: 99%

The physiological role of histamine in the exocrine pancreas

Singh

Pariente

Salido

1997

Inflammation Research

View full text Add to dashboard Cite

In addition to the autonomic nervous system and gut hormones, the mast cell mediator histamine has also been associated with exocrine pancreatic secretion. This review is concerned with the distribution and the physiological role of histamine in the control of pancreatic juice secretion. Histamine is distributed widely around blood vessels and acinar tissues in the pancreas and it is released in pancreatic juice during secretagogue stimulation. Histamine has a marked secretagogue effect in the exocrine pancreas of several animal species but in many cases the secretory effect is gender-related. The paracrine hormone exerts its secretory response via activation of H1 and H2 receptors on pancreatic acinar cells to mobilize potassium ions (K+) and cellular calcium (Ca2+) and through elevation of endogenous adenosine 3',5' cyclic monophosphate (cyclic AMP) levels, respectively. A physiological role for H3 receptors has also been associated with exocrine pancreatic secretion. H3 receptors are located presynaptically on parasympathetic nerve terminals to control the release of acetylcholine via restriction of Ca2+ access into nerve terminal through the N-type Ca2+ channel. Taken together, the results presented in this review strongly support histamine as a potential modulator of exocrine pancreatic function.

show abstract

Role of histamine receptors in rabbit pancreatic exocrine secretion stimulated by cholecystokinin and secretin

Cited by 7 publications

References 29 publications

Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

Histaminergic modulation of hormonal control in the exocrine guineapig pancreas

Activation of Histamine Receptors is Associated with Amylase Secretion and Calcium Mobilization in Guinea-Pig Pancreatic Acinar Cells

The physiological role of histamine in the exocrine pancreas

Contact Info

Product

Resources

About