A study of shear and compression deformations on hydrophilic gels of tretinoin

Lucero, M.J.; Vigo, Jean; León, M.J.

doi:10.1016/0378-5173(94)90310-7

Cited by 36 publications

(18 citation statements)

References 14 publications

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“…It was noticed that the pH values were in the range of 6.5 -6.6, which implies that these emulsions would not induce irritations or alterations of the cutaneous tegmentum if applied topically on the skin (Lucero et al, 1994). Table 3 summaries the emulsion stability indices of lipid emulsions.…”

Section: Physicochemical Properties Of Lipid Emulsionsmentioning

confidence: 99%

Lipid-Based Delivery System for Topical Phenytoin

Lee¹,

Pung²,

Khor³

et al. 2016

J App Pharm Sci

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The wound healing effect of topical phenytoin has been reported but its effective delivery system is still underresearched. The present work aimed to formulate topical lipid-based gels for effective delivery of phenytoin. Three lipid-based emulsions with different droplet sizes were prepared using coconut kernel oil (CKO) and soybean oil (SBO) blends as an oil phase. Stable lipid-based emulsion with 100% emulsion stability index (ESI) over seven heating/cooling cycles could only be formed when the oil droplet satisfied the nano size criterion, as demonstrated by nano-emulsion. The stability of macro-emulsion and cream could be enhanced by the addition of Aristoflex ammonium acryloyldimethyl-taurate/VP (AVC) copolymer as the gelling agent. These gels, designated as nano-emulgel, macro-emulgel and cream-gel, were subsequently loaded with phenytoin. All gels exhibited non-Newtonian and shear-thinning flow behavior, with high yield stress ranged 18.8 -51.5 Pa. The in vitro drug release profiles of all formulations followed the first-order kinetic model, with R 2 > 0.95. It was found that lipid nano-emulgel demonstrated the highest release rate of phenytoin, with 93.12% drug released in 12 hours, followed by cream-gel with 56.42% and macro-emulgel with 51.51%. CKO/SBO nano-emulgel was identified as the most suitable lipid topical gel formulation for effective delivery of phenytoin.

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Section: Physicochemical Properties Of Lipid Emulsionsmentioning

confidence: 99%

Lipid-Based Delivery System for Topical Phenytoin

Lee¹,

Pung²,

Khor³

et al. 2016

J App Pharm Sci

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“…Refractive index of optimized formulations was detected using an Abbe-type refractometer 27 . To standardized, the instrument castor oil was used.…”

Section: Refractive Index and Phmentioning

confidence: 99%

“…Franz diffusion apparatus having an effective diffusion [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] area of 3.14 cm 2 receptor volume was 20 ml were employed for the permeation study. The optimized skin was placed at 25 o C for 30 minutes before conducting the experiment.…”

Section: Permeation Retention Studiesmentioning

confidence: 99%

Design Development and Evaluation of Topical Microemulsion

Muzaffar¹,

Singh²

2017

Int. Res. J. Pharm.

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A microemulsion based gel was designed for the topical and targeted delivery of sertaconazole nitrate for the treatment of su perficial fungal infection. The microemulsion region was obtained using a ternary diagram, different ratio of oil and Smix were used. The microemulsion of sertaconazole containing 2% (w/w) of sertaconazole, 6.67% (w/w) of oil phase (Eugenol+Oleic acid 1:1), 60.18% (w/w) of surfactant mixture 2:1 ratio (Tween-80 and Transcutol-P) and 33.15% (w/w) with distilled water. The prepared microemulsion gel and commercial cream of sertaconazole were evaluated for in-vitro and ex-vivo studies. The highest drug retention was achieved with Tween 80 and Transcutol P (T80TC45) when the optimized formulation was converted to a gel. The designed formulation MG2 was safe to be used over the skin as the PDI=0 when compared with commercial cream and MG1. The optimized formulation also posse's anti-inflammatory activity. The average zone of inhibition of MG2 was (23.19 ± 0.478) which was more than the commercial cream (15.34 ± 0.382) or MG1 (17.78 ± 0.715). Candida albicans which may be due to better permeation and retention effect of microemulsion gel 2. The MG2 was found to be stable after six month. The results obtained in this research from in vitro and in vivo data it can be concluded that the developed microemulsions have great potential for topical drug delivery in the treatment of inflammation and fungal infection.

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“…The essential oil that showed the highest zone of inhibition with moderate yield was added to the previous polymer dispersion with stirring. For Carbopol 940, adequate amount of triethanolamine was added to neutralize free carboxylic acid groups of carbopol 940 to pH 6.8 ± 0.2 [8].…”

Section: Preparation Of Gel Bases Containing Selected Essential Oilsmentioning

confidence: 99%