Design Development and Evaluation of Topical Microemulsion

Muzaffar, Faizi; Singh, Upendra Kumar

doi:10.7897/2230-8407.089164

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…Microemulsions could be an alternative carrier in topical drug delivery and as it has high Solubilization capability and nanometer size, it is believed that microemulsion will be a better candidate in delivering drug topically. They are composed of surfactant, water, and oil having cosurfactants provide better therapeutic action when compared to the traditional cream and lotions [2].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Microemulsion Containing Neem Seed Oil

Thorat¹,

Kote²,

Patil³

et al. 2020

Int J Curr Pharm Sci

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Objective: The objective of the present study was to formulate Microemulsion containing seed oil. Neem seed (Azadirachtaindica) oil was extracted from its seeds by the soxhlet apparatus. Acetone is used as a solvent. PEG 400 and Carbopol 940p was select as surfactant, co-surfactant and hydrogel thickening agent. Microemulsions were characterized for pH, viscosity, spreadability, in vitro drug transport study and in vivo antibacterial activity and shows satisfactory results. Antibacterial activity of formulation against E. coli Shows at a concentration of 3%. The neem seed oil microemulsion has the potential for antibacterial activity. Methods: A ratio of surfactant and cosurfactant i.e, S/CoSchoosen and corresponding mixture was made. The mixture was mixed with oil. Each mixture was mixed thoroughly using magnetic stirrer until homogenous dispersion/solution was obtained. Double distilled water was used in this formulations as to prevent the incorporation of surface active impurities. The mixture was titrated with water and ambient temperature with constant stirring at the endpoint where the mixture become clouded, the quantity of aquous phase added. The percentage of three different pseudo-phases incorporated were calculated. Results: Solubility studies in various solvents reveals that the oil is insoluble in distilled water and ethanol. Soluble in methanol. Conclusion: It was observed that the microemulsion having multilamellar nature. Batches with carbopol shows better homogenous distribution. The stability of microemulsion prepared with carbopol 71 was gretter than with xanthan gum. The in vitro study of microemulsion was performed and Batch (F7) is optimized batch which shows highest drug release.

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Microemulsion Containing Neem Seed Oil

Thorat¹,

Kote²,

Patil³

et al. 2020

Int J Curr Pharm Sci

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show abstract

“…Monocaprylin was used as a co-surfactant for increasing the stability of the emulsion by possibly optimizing the hydrophile-lipophile balance (HLB) of the system, reducing interfacial tension between oil-water interfaces and promoting the occurrence of spherical oil-in-water emulsion particles (Muzaffar et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…The typical co-surfactants are short chain alcohols, medium chain alcohols, glycols, amines or acids. The role of co-surfactant includes adjusting HLB value to within the optimum range for emulsion formation, increasing the fluidity of the interface, and protecting the formation of emulsion by destroying liquid crystalline or gel structure (Muzaffar, Singh, and Chauhan, 2013).…”

Section: Co-surfactantmentioning

confidence: 99%

Preparation and antimicrobial activity of caprylic acid emulsion for food coating

Bunyovimonnat

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Antimicrobial food coating is the interesting method for food preservation, especially in fruits and vegetables. Previous studies have been reported that the caprylic acid had the antimicrobial activity against a variety of microorganisms. However, little research has been conducted on the use of caprylic acid in the form of food coatings. Therefore, this study aims to determine the optimum conditions for the caprylic acid emulsion preparation and to evaluate the antimicrobial activity of the emulsion, including the effect of food coatings with caprylic acid emulsion on physical properties and microbial growth inhibition. Emulsions containing 4% w/v caprylic acid (oil) and various concentration of surfactant mixture (polysorbate 80: monocaprylin at 1: 1 weight ratio) were prepared. The response surface methodology, Box-Behnken design, was used to optimize the factors for emulsion preparation which were surfactant concentration, sonication time and amplitude. The study showed that the optimized formula, which had small particle size, high values of zeta potential and low polydispersity index, could be prepared using 3.6% w/v surfactant mixture, sonication time of 120 sec and 30% sonication amplitude. The emulsion had the minimum bactericidal/fungicidal concentration at 0.25% w/v caprylic acid and was stable after storage at 30 ? 2 ?C and 40 ? 2 ?C, relative humidity (RH) 75 ? 5% for 28 days. Food coating formula contained caprylic acid (0.25% w/v) emulsion using 2% w/v alginate as a film-forming compound with 1.5% w/v glycerol and 2% w/v calcium chloride. Food sample (pitahaya pieces) coated with caprylic acid emulsion stored in the refrigerator for 12 days had statistically insignificant (p>0.05) change in color, weight loss and firmness compared with the uncoated food, whereas the growth of bacteria and fungi of coated samples was significantly reduced (p<0.0001). In conclusion, the caprylic acid emulsion could be used as antimicrobial food coating. Ongoing research should be conducted on sensory evaluation for further development in food preservation.

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Transdermal delivery of kojic acid from microemulgel

Nagar¹,

Mahdy²,

Selem³

et al. 2016

J App Pharm Sci

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The aim of this study was to develop microemulgel for skin delivery of kojic acid. Microemulsions (ME) containing either oleic acid (OA) or caprylic/capric triglycerides as the basic oily components were developed after construction of pseudoternary phase diagrams. Tween 80 was used as surfactant for oleic acid system both in presence and absence of ethanol or propylene glycol (PG) as cosurfactants. For the caprylic/capric systems, Tween 85 was the surfactant in presence or absence of ethanol as cosurfactant. Selected ME formulations were tested for transdermal delivery of kojic acid both in fluid state and after transformation into gel. Incorporation of cosurfactants expanded the microemulsion zone. The cosurfactant free ME were more viscous. Incorporation of kojic acid in ME systems increased the transdermal flux compared to saturated aqueous solution. caprylic/capric ME were more efficient than (OA) based ME. Transformation of the tested ME systems into gel produced significant enhancement in transdermal drug delivery compared with the saturated aqueous drug solution. However, the data revealed superior efficacy for the fluid ME systems over the corresponding microemulgel. In conclusion, both (OA) and caprylic/capric ME were promising for dermal and transdermal delivery of kojic acid even after gel formation.

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Design Development and Evaluation of Topical Microemulsion

Cited by 3 publications

References 44 publications

Formulation and Evaluation of Microemulsion Containing Neem Seed Oil

Formulation and Evaluation of Microemulsion Containing Neem Seed Oil

Preparation and antimicrobial activity of caprylic acid emulsion for food coating

Transdermal delivery of kojic acid from microemulgel

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