A study of serum magnesium and dyslipidemia in type 2 diabetes mellitus patients

Sajjan, Netravathi Basappa; Shamsuddin, M.

doi:10.5958/2394-6377.2016.00007.1

Cited by 8 publications

(5 citation statements)

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“…[32]. NADPH is an important redox cofactor for metabolic processes, including fatty acid biosynthesis, and therefore increased synthesis of triglycerides and low density lipoproteins, and hence greater accumulation of triglycerides in adipocytes which increases the extent of obesity and the risk of obesity Morbidity such as dyslipidemia, metabolic syndrome and type 2 diabetes [33,34] and in a study that indicated that the high concentration of triglycerides is linked to insulin resistance through the entry of free fatty acids into the liver and thus increase the storage of fat in adipose tissue, which leads to obesity [35,36] On the other hand, recent studies have linked magnesium with kidney patients [37] and polycystic ovary syndrome [38] and hypothyroidism patients [39]. The proportion of magnesium in women was lower than in men in obesity and overweight, as studies conducted on groups showed Different populations show that 15-42% of ostensibly healthy adults have abnormal serum Mg levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum magnesium in obesity and overweight and normal weight

et al. 2022

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The current study aimed to estimate of Magnesium Mg+ in adults in Obesity, Overweight and Normal weight and compare them and the relationship of magnesium with Body mass index BMI ,waist circumference WC and lipid profile Materials and Methods: This study included 100 people (29) 29% males and (71) 71% females whose ages were over 20 years old. They were Also divided according to nutritional status into obese group, overweight group and normal weight. The information required for the samples was recorded and BMI was measured, WC , Mg level and lipid profile were measured .Results: The results showed a decrease in the magnesium level in the obese as well as in the overweight and it was normal in the normal weight. The level of magnesium decreased in women and was higher in men in all feeding conditions, and the BMI of women was higher than that of men. The results of this work showed that there is an inverse negative relationship between Mg and each of BMI, WC, TCHO, TG ,LDL while the positive correlation between Mg and HDL.Conclusion: In finally, magnesium deficiency can be considered one of the factors that lead to obesity, and diseases associated with obesity.

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Section: Discussionmentioning

confidence: 99%

Evaluation of serum magnesium in obesity and overweight and normal weight

et al. 2022

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“…Fried Wald formula was used to calculate values of LDL. 7 Lipid profile values were according to NCEP (National Cholesterol Education Program) recommended levels. 11 3 150 and 199mg/dl.…”

Section: Evaluated Parametersmentioning

confidence: 99%

“…Mg is recognized to play a role in enzyme function including kinases .The mechanism of insulin action is through tyrosine kinase and low magnesium impairs this activity as it is essential for this enzyme. 7 Low level of magnesium is associated with defect in neuromuscular excitability. It also leads to low levels of potassium, calcium and phosphate thus increasing the problem.…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes Mellitus

Jan¹,

Saeed²,

Zia³

et al. 2018

TPMJ

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Developing countries like Pakistan have many sufferers of Diabetes Mellitus Type 2 still unprepared and unaware of the disastrous implications and complications of the disease. Local population must be aware about all factors that may worsen the disease or that may be monitored to keep them in a better status of health. Objectives: To assess the correlation between blood glucose and various parameters of lipid profile alongwith levels ofMagnesium in Type 2 diabetic patients. The aim was to help in better management of patients by monitoring dyslipidemia and mineral levels in Type2 diabetics. Study design: Cross sectional study. Setting: Madinah Teaching Hospital, Faisalabad. Period: 6 months from July to December 2017. Subjects and methods: The study was executed at Madinah Teaching Hospital Faisalabad on 50 known cases of diabetes mellitus type 2 as well as 30 healthy subjects. Estimations included Fasting blood glucose, Lipid profile and Serum Magnesium. All parameters were performed by Cobas C311 analyzer. Statistical analysis was done using SPSS version 20. Results: There was significant positive correlation between fasting blood sugar andserum cholesterol, triglycerides and LDL while a highly significant negative correlation existed between HDL and FBS. There was negative correlation among fasting blood sugar and serum Magnesium. The control group also showed low HDL and Magnesium levels. Conclusion: Hypercholesterolemia, hypertriglyceridemia, high LDL is associated with type 2 diabetes mellitus along with low HDL and hypomagnesaemia. The low levels in control group may be due to heredity or dietary factors.

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“…Hypomagnesemia has a role in the perturbation of lipid metabolism in DM. 18 It was demonstrated that subjects with hypertension have a marked increase in the prevalence of hypercholesterolemia, DM, hypomagnesemia, and hypertriglyceridemia. 19 A literature search of previous epidemiological studies showed serum magnesium was associated and correlated with various biochemical analytes mostly in T2DM with a paucity of evidence in T1DM.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Variations of Serum Magnesium with Lipid Analytes in Different Clinical Groups of Type 1 and Type 2 Diabetes Mellitus: A Hospital-based Cross-sectional Study

Kumar¹,

Kant²,

Naithani³

et al. 2020

Indian Journal of Medical Biochemistry

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Objective: Hypomagnesemia associated with dyslipidemia in type 2 diabetes mellitus (T2DM) has been well documented globally by various researchers, as there found a paucity in related data for type 1 diabetes mellitus (T1DM), present observational hospital-based cross-sectional study was planned to estimate, correlate serum magnesium with lipid analytes in different clinical groups of both T1DM and T2DM, and validate its diagnostic significance. Materials and methods:The study comprised 250 subjects with random inclusion of 200 of both T1DM, T2DM, and 50 normoglycemic healthy controls. Based on medical history and clinical records of 52 T1DM and 148 T2DM clinical cases, they were subgrouped into group I-newly diagnosed, group II-stabilized controlled, and group III-with long course, uncontrolled with associated complications. Biochemical analyses of plasma glucose, serum total magnesium, total cholesterol, and triacylglycerol were analyzed, compared, and correlated statistically with each group and healthy controls. Results: Comparison and correlations of studied analytes in T1DM and T2DM groups of subgroups with healthy controls, clearly depicted biochemical variations of hypomagnesemia in overt hyperglycemic-hyperlipidemic clinical cases. Hypomagnesemia was inversely correlated with hypertriacylglycerolemia and hypercholesterolemia in hyperglycemic of both T1DM and T2DM with varied statistical significances in different clinical groups with (p < 0.001) in group III, (p < 0.01) in group I, and (p > 0.05) non-significant in group II. However, no statistical significance (p > 0.05) for analytes was noted between type 1 and type 2 of all subgroups. Conclusion: As biochemical variations of hypomagnesemia in overt hyperglycemic-hyperlipidemic type 1 and type 2 clinical cases of diabetes mellitus was depicted and correlated, it is recommended for clinicians to prescribe serum magnesium as a routine investigation of diabetes diagnostic profile for early screening, periodic monitoring, and better management with its supplementation to prevent long-standing critical diabetes complications.

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A study of serum magnesium and dyslipidemia in type 2 diabetes mellitus patients

Cited by 8 publications

References 0 publications

Evaluation of serum magnesium in obesity and overweight and normal weight

Evaluation of serum magnesium in obesity and overweight and normal weight

Type 2 Diabetes Mellitus

Biochemical Variations of Serum Magnesium with Lipid Analytes in Different Clinical Groups of Type 1 and Type 2 Diabetes Mellitus: A Hospital-based Cross-sectional Study

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