A study of lipid profile Levels of Type II Diabetes Mellitus

Abstract

This study consists of two parts; the Part one is to evaluate the level of Blood glucose and lipid profile among diabetic patients(121 patients) which are compared with non-diabetic subjects (60 persons) and part two is to correlate lipid profile with cardiovascular abnormalities among type II diabetic patients. The diabetic patients were collected from Jabir Aboeleiz Center for Diabetes (51.9±11.22 years). Sixty healthy non-diabetic subjects were chosen as controls (52.44±10.76years). Blood glucose, total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were measured by enzymatic colorimetric methods in both groups, and low density lipoprotein cholesterol (LDL) was calculated for each sample. Among diabetic patients, there is high glucose level, serum total cholesterol, triglycerides and LDL cholesterol (p<0.5), while low level of HDL cholesterol was observed when compared to nondiabetic subjects. No statistically variation was found in the level of glucose and lipid profile between male and female diabetic patients. In our study, we have found that serum lipid -cholesterol, triglycerides and low-density lipoprotein -levels were significantly (p < 0.05) correlated to cardiovascular abnormalities, while HDL had shown a statistically non-significant correlation (p>0.05). The study concluded that higher level of cholesterol, triglyceride and LDL-cholesterol in diabetic patients compared to non-diabetic subjects with lower level of serum HDL-cholesterol in diabetic patient compared to non-diabetic subjects.

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“…value of healthy control category (P=0.000). This finding was supported by a previous study [26] that found that the mean fasting glucose level of type II diabetic patients was significantly higher (p=0.001) than that of non-diabetic subjects [26]. The mean of glucose for the hypertension group was not significantly different from the control healthy group (P=0.942), which is consistent with [27] that found no statistically significant correlation between systolic blood pressure and fasting plasma glucose, but significant correlation between fasting plasma glucose and diastolic blood pressure [27].…”

Study on Viral Infection and Related Parameters in A Sample of Diabetes Mellitus Type 2

“…In our research findings in human serum, the lipid profile tests (Cholesterol, triglyceride, LDL and VLDL) had abnormal values among studied groups, while HDL was non-significant in the mentioned groups. In accordance with a Sudanese study, all serum lipids and lipoproteins were considerably greater in diabetic patients than in non-diabetic subjects, with the exception of HLD, which was significantly lower in diabetic patients than in non-diabetic people (28) . In diabetic males and females of both age groups, however, serum TC, LDL-C, and TG levels were statistically considerably higher, but HDL-C levels were dramatically lowered (29).…”

Clinical and biochemical aspects associated with diabetic nephropathy among type 2 diabetic males in Gaza strip

“…Reduce peripheral insulin sensitivity with increased hepatic glucose output resulting in the development of hyperglycemia (König & Holzhütter 2012). Additionally, high levels of circulating fatty acids due to promotion of lipolysis, elevated levels of triglycerides, cholesterol and LDL-C with low levels of HDL-C were recognized in type 2 diabetic patients (Abd El-Azim et al 2013; Sabahelkhier et al 2016). The chronic hyperglycemia of diabetes is associated with longterm damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels.…”