A study of component release from resin pit and fissure sealants in vitro

Hamid, Abdul; Hume, W.R.

doi:10.1016/s0109-5641(97)80018-8

Cited by 103 publications

(81 citation statements)

References 19 publications

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“…From a clinical viewpoint, limitations arise concerning the correlation between in vitro and in vivo tests as well as clinical usage. However, the use of HPLC for in vitro residual monomer measuring is valuable for understanding the leaching ability of monomers from these self-adhesive resin cements at different times 4,18) . The in vitro elution of residual monomers from resin materials is related to their degree of polymerization, the properties of the resin composition, and the chemistry of the organic solvents used 24) , whereas the in vivo elution is further affected by several other factors.…”

Section: Monomer Release Analysismentioning

confidence: 99%

“…Ideally, a dental restorative resin would have all of its monomer content converted to a polymeric form during the polymerization reaction. However, the conversion of monomer into polymer is not complete during the polymerization process of resins, so varying amounts of free and unreacted monomers remain in the polymerized resin 3,4) . Unreacted monomers could be present as residual monomers, or they could be bound to the polymer backbones at one end, leaving the other end free.…”

Section: Introductionmentioning

confidence: 99%

“…Unreacted monomers could be present as residual monomers, or they could be bound to the polymer backbones at one end, leaving the other end free. The release of these residual monomers from dental resins has been widely studied in the literature [4][5][6][7] , with the main concerns being the amount of leachable monomers and the time needed for complete elution. However, little information is available regarding the role of the monomer size and chemical characteristics in this elution.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of residual monomer release and toxicity of self-adhesive resin cements

Kurt

Altıntaş

Kızıltaş

et al. 2018

Dental Materials Journal

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The aim of this study was to evaluate the amount of leached residual monomers from self-adhesive resin cements and evaluate their toxicity in-vitro. A total of 60 disk-shaped specimens (5 mm in diameter and 0.5 mm in thickness) were prepared from each cement (RelyX U200, SpeedCEM, G-Cem) (n=20). Specimens were immersed in artificial saliva and the amount of released monomers [urethane dimethacrylate (UDMA) and triethyleneglycol dimethacrylate (TEGDMA)] was identified. Then, the cytotoxicity and genotoxicity effect on cells were evaluated using the defined amounts of released monomers from cements. The highest monomer release was detected in G-Cem (p<0.05). The highest cytotoxicity value was identified from SpeedCEM (p<0.01) and the highest genotoxicity values were calculated from RelyX U200 (p<0.05). Released UDMA and TEGDMA from self-adhesive resin cements induced cytotoxicity and genotoxicity effect on cells.

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Section: Monomer Release Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of residual monomer release and toxicity of self-adhesive resin cements

Kurt

Altıntaş

Kızıltaş

et al. 2018

Dental Materials Journal

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“…Once these residual monomers reach the pulp tissue, a foreign body reaction may be elicited, causing some inflammatory effects 10,11) . Monomers like Bis-GMA, HEMA, UDMA, TEGDMA, initiators, and solvents have already been associated with cytotoxic effects on fibroblast and odontoblast-like cells 12,13) .…”

Section: Introductionmentioning

confidence: 99%

“…Several reports have indicated that these components individually or in combination ultimately compromise the pulp healing process 10,12,13) . Moreover, in deep cavity preparations, the high water content may prevent adequate polymerization of resinous materials, which in turn may release high levels of unconverted components into an adjacent aqueous phase that can diffuse through dentin to the pulp 10,11) . On the contrary, interactions between the different resinous materials were reported to be less toxic than the sum of the individual toxicities 14) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Curing Method of a Dual-cure Resin Cement on Monkey Pulpal Reaction after Bonding of Tooth-colored Inlay

et al. 2007

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To compare the pulpal responses to light-cured and self-cured resin cements, cervical cavities were prepared in monkey's teeth, followed by application of etching gel and adhesive (Single Bond). A dual-cure resin cement (RelyX™ ARC) was applied, and hybrid composite inlays (Estenia) were bonded to the cavities. In one group, the cavities were photoirradiated for 20 seconds and the resin cement light-cured. In the other group, the resin cement was self-cured for six minutes without any photoirradiation. After experimental periods of seven, 28, and 70 days, histological features of pulp tissue were evaluated and compared. Results showed no significant differences in the histological features of the pulp tissues between the two curing methods. Both light-cured and self-cured resin cements showed acceptable biological compatibility with the monkey pulp. No bacterial penetration along the cavity walls was detected with either curing method.

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Variability of cytotoxicity and leaching of substances from four light-curing pit and fissure sealants

Geurtsen

Spahl²,

Leyhausen

1999

J. Biomed. Mater. Res.

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It was the aim of our study to investigate the composition and cytotoxicity of aqueous extracts of four light-curing pit and fissure sealants. Water extracts were analyzed by gas chromatography/mass spectrometry (GC/MS), and relative quantities of identified compounds were compared by means of an internal caffeine standard [%CF]. Cytotoxic effects due to medium extracts were determined by means of permanent 3T3 fibroblasts. All light-curing pit and fissure sealants segregated different ingredients into water, such as co-monomers (mainly ethylene glycol compounds) and initiating substances (e.g., camphorquinone). Bisphenol-A, however, which is easily detected by GC/MS, was not found in any of the analyzed eluates. The extracts of three sealants inhibited monolayer growth only moderately whereas the eluate of one product inhibited cell proliferation significantly. In the extracts of this sealant high quantities [%CF] of the co-monomer TEGDMA were detected. Our results indicate that light-curing pit and fissure sealants release substances into aqueous media that may induce cytotoxic effects. However, no concerns about potential estrogenic effects of Bisphenol-A are supported by our results.

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A study of component release from resin pit and fissure sealants in vitro

Cited by 103 publications

References 19 publications

Evaluation of residual monomer release and toxicity of self-adhesive resin cements

Evaluation of residual monomer release and toxicity of self-adhesive resin cements

Effect of Curing Method of a Dual-cure Resin Cement on Monkey Pulpal Reaction after Bonding of Tooth-colored Inlay

Variability of cytotoxicity and leaching of substances from four light-curing pit and fissure sealants

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