A study of certain herbs Against chlorpyrifos-induced changes in lipid and protein profile in poultry

Abstract

A total of 225 male broiler chicks (Cobb strain) of day-old age were procured for the study. The chicks were randomly divided into 15 groups consisting of 15 chicks in each group. Group 1 was maintained as basal diet control and group 2 on chlorpyrifos (CPS) at 100 ppm in feed throughout 6 wk as iron toxic control without any treatment. Groups 3-15 were maintained on CPS at 100 ppm in feed for the 4 wk (28 days) of study and thereafter administered with different herbs and their combinations for remaining 2 wk. The blood samples were drawn from wing vein on 28th day and 42nd day from the birds in each group for the estimation of lipid and protein profiles. The birds were sacrificed at the end of 6th week and liver tissues were collected for histological examination. The concentrations of total cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, total protein, albumin and globulins and the A/G ratio were increased significantly (P<;0.05) in toxic groups (2–15), while high density lipoprotein (HDL) cholesterol was significantly (P<;0.05) decreased at the end of 4th week. However, following supplementation of herbs and herbal combinations, the values of lipid and protein profile in groups 3–15 revived toward normal at the end of 6th week. Histopathology of liver in CPS toxic control (group 2) revealed areas of degeneration, while groups 3–15 that were treated with herbs and their combinations exhibited these changes in a milder form, indicating regenerative alterations. The study revealed that chorpyrifos-induced changes in lipid and protein profile were improved by supplementation of certain herbs.

Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats

“…The inquiry on the pharmacological activity of diverse plants and plant products is growing considerably in the recent past. Novel applications of plants and plant products such as amelioration of heavy metal induced toxicities,[ 4 5 6 ] synthesis of nanoparticles[ 7 8 9 ] including normalization of dyslipidemias[ 10 11 12 ] have been reported. Chickpea or Bengal gram ( Cicer arientum L) is the second largest legume cultivated in the world providing a rich source of dietary protein.…”

Evaluation of the acute basic biological effects of herbal formulation to control obesity: a preliminary study

“…The serum cholesterol level was decreased which directly triggers the activity of lecithin-cholesterol acyl transferase due to the presence of saponin in polyherbal formulation (Bharathi et al, 2011). The serum cholesterol level was reduced due to the increase in activity of lipoprotein lipase and presence of cholesterol-7-hydroxylase, hepatic 3-methyglutaryl-COA reductase, and fatty acid synthetase (Singh et al, 2016;Bharathi et al, 2011). Polyherbal formulation shows the hypolipidemic properties and antioxidant properties which decreases the low-density lipoprotein, total cholesterol, very low-density lipoprotein, and increase the high-density lipoproteins (Parasuraman et al, 2010).…”

“…The lipid level was reduced in treated animal due to presence of alkaloids, glycoside, and flavonoids components in prepared herbal formulation (Kumar et al ., 2023). The serum cholesterol level was decreased which directly triggers the activity of lecithin‐cholesterol acyl transferase due to the presence of saponin in polyherbal formulation (Bharathi et al ., 2011). The serum cholesterol level was reduced due to the increase in activity of lipoprotein lipase and presence of cholesterol‐7‐hydroxylase, hepatic 3‐methyglutaryl‐COA reductase, and fatty acid synthetase (Singh et al ., 2016; Bharathi et al ., 2011).…”

Hematobiochemical alterations of acute chlorpyriphos intoxication in indigenous chicken

“…It is used as an insecticide on grain, fruit nut, and vegetable crops. Residual amounts of CPF are detected in water, soil, fabric, and on surfaces for months to years [2]. CPF is also applied to the soil surrounding or beneath buildings as protection against termites including chicken houses [3].…”